DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est6 and cest-25

DIOPT Version :9

Sequence 1:	NP_524262.1	Gene:	alpha-Est6 / 40902	FlyBaseID:	FBgn0015574	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_497609.1	Gene:	cest-25 / 175390	WormBaseID:	WBGene00022178	Length:	550	Species:	Caenorhabditis elegans

Alignment Length:	526	Identity:	158/526 - (30%)
Similarity:	240/526 - (45%)	Gaps:	57/526 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 SKVVKLSVGSVKGRRLSGIYGDEFYSFEGIPFAKPPLGKARFVASQLADPWNSELDARQERPIPL 104
            |:.|..|.|.::||||......:..:|:|||:|.||:|..||...|..:.|....:.:......:
Worm    16 SRQVLTSYGPIEGRRLIHEGEKQVDAFQGIPYAAPPIGNLRFALPQPHEKWTEVRETKSFGARGI 80

  Fly   105 QMDRRSGKVVG--SEDCLYLNVYTKHFN-ESEPPLPVMVYIYGGAFRTGGAVKSKYGP----DYL 162
            |.|........  |||.|.||::|..:. ::|...||::||:||.|.:..|  .|||.    .:|
Worm    81 QKDHVLSPKTSPQSEDNLTLNIFTPVWTPKNETGFPVILYIHGGGFVSDSA--HKYGDMSICQHL 143

  Fly   163 MSRDVVYVLFNYRLCSLGFLSMPSGKLDVPGNAGLHDQLLALQWVSQHIRNFNGDPQNITLFGES 227
            :::|||.|...|||..|||.:  :|...:|.|..|||.:.||:||.::|..|||||.||||.|:|
Worm   144 VTKDVVVVTIQYRLGFLGFWT--TGDSSIPDNVALHDMVFALKWVKENIGLFNGDPNNITLMGQS 206

  Fly   228 AGAASVHFMMCLPQAKGLFHKAIMMSGSMLSPWV----------NAPDSDGIFCRLATSAGYEGP 282
            ||.|||.|:...|.::.||.|.|.|.|:....|.          |.....|:|..:.|....| .
Worm   207 AGGASVDFLSISPVSRDLFQKVIPMGGNASCSWAIHPRPLNACRNRAQEIGVFDGMNTLDWVE-K 270

  Fly   283 AEEVPILEFLRNVNAE----KLIGHDFISPRDRCFGFLNPFAPVVGGLVAAPFQQLMKEAWSCEV 343
            ..|:|..:|...:|.|    |......|.|:     :.|.|.|       .|..:|.|||  ...
Worm   271 LRELPADKFASALNMEAVDTKTDPELLIGPK-----YDNLFIP-------RPVMELRKEA--PMK 321

  Fly   344 PLLLGGTSFEGLVYYPFCQLDNGYMLELLKHEPAMVLPHELYQSMSVEERNTAADVLVKYHYGPR 408
            |.|||....|||| :.|..|:..:.|..::.:.:.:|..:|:...:.:.:..|.:.|::  .|..
Worm   322 PRLLGCAKSEGLV-FAFFGLNTKHPLHAVQQDVSAILSEKLFPLKARDYQEKALEKLIE--IGTD 383

  Fly   409 GITKSNITQILDLFSYKLFWHGIHRVVLSRL-SHAQAPTYLYRFDFDSPK-LNLMRNQLCGDDIK 471
            ...:.....::||........||.:.||..| :....|.|:|.||:.:|| ..:|..:|...|
Worm   384 HSKEEWQRAMVDLKGDSFLNVGIQQNVLDVLETQPSTPIYMYSFDYCNPKAYGIMGFKLPFKD-- 446

  Fly   472 RGVCHADDLGYIFHKQAQAKQPLDSPEFLTIQRMVGILTTFARTGDPNCPETGPD------PWMP 530
              ..|..|:.|:...........:..::..|:....:.|.||:.|:||  ..|.|      .|.|
Worm   447 --ATHCTDISYVVGNHIVNSFDFNEEDYKMIEITTRLWTNFAKYGNPN--GEGDDVAHLEEKWEP 507

  Fly   531 VSTKSP 536
            .:.:||
Worm   508 ATIESP 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est6	NP_524262.1	COesterase	35..534	CDD:278561	156/522 (30%)
alpha-Est6	NP_524262.1	Aes	<133..325	CDD:223730	75/209 (36%)
cest-25	NP_497609.1	COesterase	18..536	CDD:365897	157/524 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm14771
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.810