DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est6 and Ces3b

DIOPT Version :9

Sequence 1:	NP_524262.1	Gene:	alpha-Est6 / 40902	FlyBaseID:	FBgn0015574	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_653094.2	Gene:	Ces3b / 13909	MGIID:	3644960	Length:	571	Species:	Mus musculus

Alignment Length:	579	Identity:	157/579 - (27%)
Similarity:	241/579 - (41%)	Gaps:	123/579 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 KVVKLSV----GSVKGRRLSGIYGDEFYS-FEGIPFAKPPLGKARFVASQLADPWNSELDARQER 100
            ||::..|    |.|:||::.....|...: |.|||||:.|:|..||.|.....||....||....
Mouse    33 KVIQPEVDTPLGRVRGRQVGVKDTDRMVNVFLGIPFAQAPVGPLRFSAPLPPQPWEGVRDASINP 97

  Fly   101 PIPLQ-----MDRRSG-----KVVG-SEDCLYLNVYTKHFNESEPPLPVMVYIYGGAFRTG---- 150
            |:.||     ::.|.|     |:.. |||||.||:|:.....:....||||:|:||:...|
Mouse    98 PMCLQDVEKMINSRFGLNEKIKIFPISEDCLTLNIYSPTEITAGDKRPVMVWIHGGSLLVGSSTS 162

  Fly   151 --GAVKSKYGPDYLMSRDVVYVLFNYRLCSLGFLSMPSGKLDVPGNAGLHDQLLALQWVSQHIRN 213
              |:..:.||       |||.|...|||...||||  :|...:|||.|..|.:.||:||..:|..
Mouse   163 QDGSALAAYG-------DVVVVTVQYRLGIFGFLS--TGDKHMPGNRGFLDVVAALRWVQGNIAP 218

  Fly   214 FNGDPQNITLFGESAGAASVHFMMCLPQAKGLFHKAIMMSGSM-------LSPWVNAPD-SDGIF 270
            |.|||..:|:||.|||...|..:...|.:.||||:||..||.:       :.||..|.: ::.:.
Mouse   219 FGGDPNCVTIFGNSAGGMIVSSLFLSPISAGLFHRAISQSGIVTTIMMEDMKPWPEAQNFANSVA 283

  Fly   271 CRLATSAGYEGPAEEVPIL------EFL--RNVNAEKLIGHDFISPRDRCFGFLNPFAPVVGGLV 327
            |      |...|||.|..|      :.:  :|||...::...|...|.
Mouse   284 C------GSASPAELVQCLLQKEGKDLIKQKNVNISYIVNDSFFPQRP----------------- 325

  Fly   328 AAPFQQLMKEAWSCEVPLLLGGTSFEGLVYYPFCQLDNGYMLELLKH----------EP---AMV 379
                ::|:.:.....||.|||.|:.|    :.:..|.:..:|:.|:|          .|   .|.
Mouse   326 ----EKLLADQQFPTVPYLLGVTNHE----FGWLLLKSLNILDKLEHLSREDLLEISRPFLAIME 382

  Fly   380 LPHELYQSMSVEERNTAADVLVKYHYGPRGITKSNITQILDLFSYKLFWHGIHRVVLSR-LSHAQ 443
            :|.|:..::..|..:..:|         :..|:....::|...|:.     |..:..|: |..|.
Mouse   383 VPPEIMPTVIDEYLDNGSD---------QSATRYAFQELLGDISFI-----IPTLNFSKYLRDAG 433

  Fly   444 APTYLYRFDFDSPKLNLMRNQLCGDDIKRGVCHADDLGYIFHKQ--AQAKQPLDSPEFLTIQRMV 506
            .|.:||.|..........:......|      ||.:..::|...  ......|..||....::.:
Mouse   434 CPVFLYEFQHTPSSFAKFKPAWVKAD------HASENSFVFGGPFLTDESSLLAFPEATEEEKQL 492

  Fly   507 GIL-----TTFARTGDPNCPETGPDPWMPVSTKSPFKALNIGQQVECVTQVEKDGLKVW 560
            .:.     :.|||||:||  ..|..||..::....:  |.||.:.....:::|..|:.|
Mouse   493 SLTMMAQWSQFARTGNPN--GKGLPPWPQLNQLEQY--LEIGLESRTGVKLKKGRLQFW 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est6	NP_524262.1	COesterase	35..534	CDD:278561	151/551 (27%)
alpha-Est6	NP_524262.1	Aes	<133..325	CDD:223730	68/213 (32%)
Ces3b	NP_653094.2	COesterase	36..547	CDD:278561	154/574 (27%)
		Aes	75..>245	CDD:223730	65/178 (37%)
		Prevents secretion from ER. /evidence=ECO:0000255	568..571
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832493
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.740