Protein Alignment alpha-Est6 and AADACL3

DIOPT Version :10

• Sequence 1: NP_524262.1
• Gene: alpha-Est6 / 40902
• FlyBaseID: FBgn0015574
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_001096640.2
• Gene: AADACL3 / 126767
• HGNCID: 32037
• Length: 407
• Species: Homo sapiens
• Alignment Length: 284
• Identity: 54/284 - (19%)
• Similarity: 98/284 - (34%)
• Gaps: 94/284 - (33%)

  Fly   137 PVMVYIYGGAFRTGGAVKSKYGPDYLMSRDVVYVLFNYRLC--------SLGFLSMPSGKLDVPG 193
            |.:||.:||. ...|::|:.:|   :.|          |||        ::|:..:|..|..||
Human   113 PGIVYYHGGG-GVMGSLKTHHG---ICS----------RLCKESDSVVLAVGYRKLPKHKFPVP- 162

  Fly   194 NAGLHDQLLALQWVSQHIRNFNGDPQNITLFGESAGAASVHFMMCLPQAKGLFHKAIMMSGSMLS 258
               :.|.|:|.....:.:..:..||..:.:.|:|.|.| :..::|                   .
Human   163 ---VRDCLVATIHFLKSLDAYGVDPARVVVCGDSFGGA-IAAVVC-------------------Q 204

  Fly   259 PWVNAPDSDGIFCRLATSAGYEGPAEEVPILEFLRNVNAEKLIGHDFISPRDRCFGFLNPFAPVV 323
            ..|:.||...|..::...|..:....:.|..:..:|:   .|:...||     |:.|
Human   205 QLVDRPDLPRIRAQILIYAILQALDLQTPSFQQRKNI---PLLTWSFI-----CYFF-------- 253

  Fly   324 GGLVAAPFQQL-MKEAWSCEVPLLLGGTSFEGLVYYPFCQ-----------LDNGYMLELLKHEP 376
                   ||.| ...:|.   .:::.|......|:..:.:           .:.||.|:
Human   254 -------FQNLDFSSSWQ---EVIMKGAHLPAEVWEKYRKWLGPENIPERFKERGYQLK------ 302

  Fly   377 AMVLPHELYQSMSVEERNTAADVL 400
                |||.....:..|.:...||:
Human   303 ----PHEPMNEAAYLEVSVVLDVM 322

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est6	NP_524262.1	COesterase	39..536	CDD:395084	54/284 (19%)
AADACL3	NP_001096640.2	Abhydrolase_3	115..378	CDD:400284	53/282 (19%)
		Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole. /evidence=ECO:0000250|UniProtKB:Q5NUF3	119..121		0/1 (0%)