DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est6 and Ache

DIOPT Version :9

Sequence 1:	NP_524262.1	Gene:	alpha-Est6 / 40902	FlyBaseID:	FBgn0015574	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	XP_036020624.1	Gene:	Ache / 11423	MGIID:	87876	Length:	616	Species:	Mus musculus

Alignment Length:	590	Identity:	182/590 - (30%)
Similarity:	272/590 - (46%)	Gaps:	78/590 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 FLILRCCPGFKRFSCQSAGDADSK-VVKLSVGSVKGRRLSGIYGDEFYSFEGIPFAKPPLGKARF 81
            ||:|....|    ..::.|..|.: :|::..|.::|.||.. .|....:|.|||||:||:|..||
Mouse    19 FLLLSLLGG----GARAEGREDPQLLVRVRGGQLRGIRLKA-PGGPVSAFLGIPFAEPPVGSRRF 78

  Fly    82 VASQLADPWNSELDARQERPIPLQ-MDRRSGKVVG----------SEDCLYLNVYTKHFNESEPP 135
            :..:...||:..|||...:.:..| :|.......|          |||||||||:|. :.....|
Mouse    79 MPPEPKRPWSGVLDATTFQNVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTP-YPRPASP 142

  Fly   136 LPVMVYIYGGAFRTGGAVKSKYGPDYLMS-RDVVYVLFNYRLCSLGFLSMPSGKLDVPGNAGLHD 199
            .||:::||||.|.:|.|....|...:|.. ...|.|..|||:.:.|||::| |..:.|||.||.|
Mouse   143 TPVLIWIYGGGFYSGAASLDVYDGRFLAQVEGAVLVSMNYRVGTFGFLALP-GSREAPGNVGLLD 206

  Fly   200 QLLALQWVSQHIRNFNGDPQNITLFGESAGAASVHF-MMCLPQAKGLFHKAIMMSGSMLSPWVNA 263
            |.||||||.::|..|.|||.::||||||||||||.. ::.|| ::.|||:|::.||:...||...
Mouse   207 QRLALQWVQENIAAFGGDPMSVTLFGESAGAASVGMHILSLP-SRSLFHRAVLQSGTPNGPWATV 270

  Fly   264 PDSDG-----IFCRLATSAGYEGPAEEVPILEFLRNVNAEKLIGHDF-ISPRDRCFGFLNPFAPV 322
            ...:.     :..||...........:..::..||...|:.|:.|:: :.|::..|.|  .|.||
Mouse   271 SAGEARRRATLLARLVGCPPGGAGGNDTELIACLRTRPAQDLVDHEWHVLPQESIFRF--SFVPV 333

  Fly   323 VGG--LVAAPFQQLMKEAWSCEVPLLLGGTSFEG---LVY-YPFCQLDNGYMLELLKHEPAMVLP 381
            |.|  |...| :.|:......::.:|:|....||   ||| .|....||..::...:....:
Mouse   334 VDGDFLSDTP-EALINTGDFQDLQVLVGVVKDEGSYFLVYGVPGFSKDNESLISRAQFLAGV--- 394

  Fly   382 HELYQSMSVEERNTAADVLVKYHYGPRGITKSNITQILDLFSYKLFWHGIHRVV------LSRLS 440
                 .:.|.:.:..|...|..|| ...:...:.|.:.|..|..:   |.|.||      ..||:
Mouse   395 -----RIGVPQASDLAAEAVVLHY-TDWLHPEDPTHLRDAMSAVV---GDHNVVCPVAQLAGRLA 450

  Fly   441 HAQAPTYLYRFDFDSPKLNLMRNQLCGDDIKRGVCHADDLGYIFHKQAQAKQPLD------SPEF 499
            ...|..|.|.|:..:..|..        .:..||.|..::.:||      ..|||      :.|.
Mouse   451 AQGARVYAYIFEHRASTLTW--------PLWMGVPHGYEIEFIF------GLPLDPSLNYTTEER 501

  Fly   500 LTIQRMVGILTTFARTGDPNCPETGPDP-WMPVSTKS-PFKALNIGQQVECVTQVEKDGLKVWNR 562
            :..||::...|.||||||||.|.....| |.|.:|.: .:.:||: :.:|....:.......|||
Mouse   502 IFAQRLMKYWTNFARTGDPNDPRDSKSPQWPPYTTAAQQYVSLNL-KPLEVRRGLRAQTCAFWNR 565

  Fly   563 LYSDL 567
            ....|
Mouse   566 FLPKL 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est6	NP_524262.1	COesterase	35..534	CDD:278561	170/537 (32%)
alpha-Est6	NP_524262.1	Aes	<133..325	CDD:223730	76/199 (38%)
Ache	XP_036020624.1	COesterase	37..563	CDD:395084	172/559 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832860
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4180
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.790