Protein Alignment alpha-Est6 and CES1

DIOPT Version :9

• Sequence 1: NP_524262.1
• Gene: alpha-Est6 / 40902
• FlyBaseID: FBgn0015574
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_001020366.1
• Gene: CES1 / 1066
• HGNCID: 1863
• Length: 568
• Species: Homo sapiens
• Alignment Length: 594
• Identity: 181/594 - (30%)
• Similarity: 263/594 - (44%)
• Gaps: 121/594 - (20%)

  Fly    35 AGDADSKVVKLSVGSVKGRRLSGIYGDEFYS-----FEGIPFAKPPLGKARFVASQLADPWN--- 91
            ||...|..|   |.:|.|:.|......|.::     |.||||||||||..||...|.|:||:
Human    18 AGHPSSPPV---VDTVHGKVLGKFVSLEGFAQPVAIFLGIPFAKPPLGPLRFTPPQPAEPWSFVK 79

  Fly    92 -------------------SELDARQERPIPLQMDRRSGKVVGSEDCLYLNVYTKHFNESEPPLP 137
                               |||...::..|||::         ||||||||:||......:..||
Human    80 NATSYPPMCTQDPKAGQLLSELFTNRKENIPLKL---------SEDCLYLNIYTPADLTKKNRLP 135

  Fly   138 VMVYIYGGAFRTGGAVKSKY-GPDYLMSRDVVYVLFNYRLCSLGFLSMPSGKLDVPGNAGLHDQL 201
            |||:|:||....|.|  |.| |.......:||.|...|||...||.|  :|.....||.|..||:
Human   136 VMVWIHGGGLMVGAA--STYDGLALAAHENVVVVTIQYRLGIWGFFS--TGDEHSRGNWGHLDQV 196

  Fly   202 LALQWVSQHIRNFNGDPQNITLFGESAGAASVHFMMCLPQAKGLFHKAIMMSG-SMLSPWVNAPD 265
            .||:||..:|.:|.|:|.::|:||||||..||..::..|.||.|||:||..|| ::.|..|...|
Human   197 AALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAISESGVALTSVLVKKGD 261

  Fly   266 SDGIFCRLATSAGYEGPAEEVPILEFLRNVNAEKL----IGHDFIS------PRDRCFGFLNPFA 320
            ...:..::|.:||.:.....| ::..||....|:|    :...|:|      ||:.        .
Human   262 VKPLAEQIAITAGCKTTTSAV-MVHCLRQKTEEELLETTLKMKFLSLDLQGDPRES--------Q 317

  Fly   321 PVVGG------LVAAPFQQLMKEAWSCEVPLLLGGTSFE-------GLVYYPFC--QLDNGYMLE 370
            |::|.      |:..| ::|..|.....||.::|....|       .|:.||..  |||....:.
Human   318 PLLGTVIDGMLLLKTP-EELQAERNFHTVPYMVGINKQEFGWLIPMQLMSYPLSEGQLDQKTAMS 381

  Fly   371 LL-KHEPAMVLPHELYQSMSVEERNTAADVLVKYHYGPRGITKSNITQILDLFSYKLFWHGIHRV 434
            || |..|.:.:..||... :.|:.....|..||         |.::  .|||.:..:|  |:..|
Human   382 LLWKSYPLVCIAKELIPE-ATEKYLGGTDDTVK---------KKDL--FLDLIADVMF--GVPSV 432

  Fly   435 VLSRLSH--AQAPTYLYRFDF-DSPKLNLMRNQLCGDDIKRGVCHADDL----GYIFHKQAQAKQ 492
            :::| :|  |.||||:|.|.: .|...::....:.||       |.|:|    |..|.|:..
Human   433 IVAR-NHRDAGAPTYMYEFQYRPSFSSDMKPKTVIGD-------HGDELFSVFGAPFLKEGA--- 486

  Fly   493 PLDSPEFLTIQRMV-GILTTFARTGDPNCPETGPDPWMPVSTKSPFKALNIGQQVECVTQVEKDG 556
               |.|.:.:.:|| .....|||.|:||  ..|...|...:.|..:  |.||...:...:::...
Human   487 ---SEEEIRLSKMVMKFWANFARNGNPN--GEGLPHWPEYNQKEGY--LQIGANTQAAQKLKDKE 544

  Fly   557 LKVWNRLYS 565
            :..|..|::
Human   545 VAFWTNLFA 553

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est6	NP_524262.1	COesterase	35..534	CDD:278561	175/561 (31%)
		Aes	<133..325	CDD:223730	71/203 (35%)
CES1	NP_001020366.1	COesterase	25..548	CDD:278561	176/580 (30%)
		Aes	<122..>240	CDD:223730	50/121 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142671
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	216	1.000	Inparanoid score	I3612
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.800