DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est6 and ces3.5

DIOPT Version :9

Sequence 1:	NP_524262.1	Gene:	alpha-Est6 / 40902	FlyBaseID:	FBgn0015574	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	XP_031756661.1	Gene:	ces3.5 / 100493652	XenbaseID:	XB-GENE-6467133	Length:	557	Species:	Xenopus tropicalis

Alignment Length:	591	Identity:	171/591 - (28%)
Similarity:	264/591 - (44%)	Gaps:	105/591 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 FLI---LRCCPGFKRFSCQSAGDADSKV-VKLSVGSVKGRRLSGIYGD-EFYSFEGIPFAKPPLG 77
            |||   |.||...:.:   .||..|::. :....|.:.|:.::....| ..::|.|:||||.|:|
Frog     3 FLIKELLLCCVTLEIY---GAGQEDARPRLTTKYGQLLGKTVNVRGADRHVHAFMGVPFAKAPVG 64

  Fly    78 KARFVASQLADPWNSELDARQERPIPLQ--MDR--RSGKV-----VGSEDCLYLNVYTKHFNESE 133
            ..||...|..:||:|..:|....|:.||  |::  :..|:     ..|||||||||:|....:..
Frog    65 HLRFADPQPPEPWSSIREASVIPPMCLQHGMEQLIKLFKIEFVLPASSEDCLYLNVFTPADRKEN 129

  Fly   134 PPLPVMVYIYGGAFRTG------GAVKSKYGPDYLMSRDVVYVLFNYRLCSLGFLSMPSGKLDVP 192
            ..|||||:|:||....|      |:..|.|       .:||.|...|||..|||.|  :|..:..
Frog   130 SKLPVMVFIHGGGLLMGLASMFDGSALSGY-------ENVVVVSIQYRLGILGFFS--TGDKEAQ 185

  Fly   193 GNAGLHDQLLALQWVSQHIRNFNGDPQNITLFGESAGAASVHFMMCLPQAKGLFHKAIMMSGSML 257
            ||.|..||:.||:||.::|:.|.|||:::|:||:|||..||...:..|.:|||||:||..||..|
Frog   186 GNFGFLDQVAALKWVQENIKEFGGDPESVTIFGQSAGGLSVSTHVLSPLSKGLFHRAIAESGVAL 250

  Fly   258 SP-WVNAPDSDGIFCR--LATSAG--YEGPAEEVPILEFLRNVNAEKLIGHDFISPRDRCFGFLN 317
            .| .|.:...:.:|.|  :|:.:|  .:|      :::.|:....|:::.   ||   ....|..
Frog   251 LPGLVVSKTEEVLFVRDLVASLSGCNIKG------LVDCLKKKTEEEIMA---IS---ATMQFTA 303

  Fly   318 PFAPVVGGLVAAPFQQLMKEAWSCEVPLLLGGTSFEGLVYYPFCQLDNGYMLELLKHEPAMVLPH 382
            ..|.|.|..:..|.::::....|..||.|:|..:.|.....|.....:|:...:.:.|...||..
Frog   304 LPACVDGVFLPKPVEEILANKESNRVPFLIGFNNNEFGWMLPMALNISGFREGMGRKEVQSVLSA 368

  Fly   383 -ELYQSMSVEERNTAADVLVKYHYGPRGITKSNITQILDLFSYKLFWHGIHRVVLSRLSHAQ--- 443
             .|..|:|     :...:|:|.::|..........:.|:|....||       |:..|..||
Frog   369 LPLLHSVS-----SLVPLLMKEYFGDTNDQTEIRNKFLELNGDILF-------VIPALRTAQYHR 421

  Fly   444 ---APTYLYRFD-----FDSPKLNLMRNQLCGDDIKRGVCHADDLGY-----------IFHKQAQ 489
               .|.|||.|.     :|:.|          ||..: ..|.|:|.:           ||....
Frog   422 DSGLPVYLYEFQHRPSLYDNSK----------DDFVK-ADHGDELYFVLGGPFLNGDAIFQSDG- 474

  Fly   490 AKQPLDSPEFLTIQRMVGILTTFARTGDPNCPETGPDPWMPVSTKSPFKALNIGQQVECVTQVEK 554
                .|..:.|: :.|:.....|||.||||.|  |...|........:..:|:.|:..  .::::
Frog   475 ----TDEEKNLS-KTMMKYWANFARNGDPNGP--GLVEWPAYDEDKDYLEINLKQKSS--WRLKE 530

  Fly   555 DGLKVW 560
            ..||.|
Frog   531 GRLKFW 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est6	NP_524262.1	COesterase	35..534	CDD:278561	160/543 (29%)
alpha-Est6	NP_524262.1	Aes	<133..325	CDD:223730	70/202 (35%)
ces3.5	XP_031756661.1	COesterase	27..536	CDD:395084	161/562 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010