DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est7 and Ache

DIOPT Version :9

Sequence 1:	NP_524261.1	Gene:	alpha-Est7 / 40901	FlyBaseID:	FBgn0015575	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	XP_038945765.1	Gene:	Ache / 83817	RGDID:	69313	Length:	616	Species:	Rattus norvegicus

Alignment Length:	519	Identity:	163/519 - (31%)
Similarity:	241/519 - (46%)	Gaps:	88/519 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 GQVRGIKRLSLYDVPYFSFEGIPYAQPPVGELRFKAPQRPIPWERVRDCSQPKDKAVQ-VQFVFD 103
            ||:||| ||.....|..:|.|||:|:||||..||..|:...||..:.|.:..::...| |..::.
  Rat    46 GQLRGI-RLKAPGGPVSAFLGIPFAEPPVGSRRFMPPEPKRPWSGILDATTFQNVCYQYVDTLYP 109

  Fly   104 KVEG----------SEDCLYLNVYTNNVKPDKARPVMVWIHGGGFIIGEANREWYGPDYFMK-ED 157
            ..||          |||||||||:|...:|....||::||:||||..|.::.:.|...:..: |.
  Rat   110 GFEGTEMWNPNRELSEDCLYLNVWTPYPRPTSPTPVLIWIYGGGFYSGASSLDVYDGRFLAQVEG 174

  Fly   158 VVLVTIQYRLGALGFMSLKSPELNVPGNAGLKDQVLALKWIKNNCASFGGDPNCITVFGESAGGA 222
            .|||::.||:|..||::|.... :.|||.||.||.|||:|::.|.|:|||||..:|:||||||.|
  Rat   175 TVLVSMNYRVGTFGFLALPGSR-DAPGNVGLLDQRLALQWVQENIAAFGGDPMSVTLFGESAGAA 238

  Fly   223 STHYMMLTDQTQGLFHRGILQSGSAICPWA--YNGDITHNPYRIAKLVGYK---GEDNDKDVLEF 282
            |....:|:..::.||||.:||||:...|||  ..|:.......:|:|||..   ...||.:::..
  Rat   239 SVGMHILSLPSRSLFHRAVLQSGTPNGPWATVSAGEARRRATLLARLVGCPPGGAGGNDTELISC 303

  Fly   283 LQNVKAKDLIRVEENVLTLEERMNKIMFAFGPSLE-PFSTPECVISKPPKEMMKTAWSNSIPMFI 346
            |:...|:||:..|.:||..|   :...|:|.|.:: .|      :|..|:.::.|.....:.:.:
  Rat   304 LRTRPAQDLVDHEWHVLPQE---SIFRFSFVPVVDGDF------LSDTPEALINTGDFQDLQVLV 359

  Fly   347 GNTSYEGLLWVPEVKLMPQVLQQLDAGTPFIPKELLATEPSKEKLDSWSAQIRDVHRTGSESTPD 411
            |....||..:             |..|.|...|:       .|.|.| .||.....|.|.....|
  Rat   360 GVVKDEGSYF-------------LVYGVPGFSKD-------NESLIS-RAQFLAGVRIGVPQASD 403

  Fly   412 NYMDLCSIYYFVF-----PALRVVHSRHAYAA---------------------GAPVYFYRYDFD 450
            ...:...::|..:     ||    |.|.|.:|                     ||.||.|.::..
  Rat   404 LAAEAVVLHYTDWLHPEDPA----HLRDAMSAVVGDHNVVCPVAQLAGRLAAQGARVYAYIFEHR 464

  Fly   451 SEELIFPYRIMRLGRGVKGVSHADDLSYQFSSLLARRLPKESREYRNIERTVGIWTQFAATGNP 514
            :..|.:|..:        ||.|..::.:.|...|...|.....|....:|.:..||.||.||:|
  Rat   465 ASTLTWPLWM--------GVPHGYEIEFIFGLPLDPSLNYTVEERIFAQRLMKYWTNFARTGDP 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est7	NP_524261.1	COesterase	27..514	CDD:278561	162/517 (31%)
alpha-Est7	NP_524261.1	Aes	<116..>221	CDD:223730	47/105 (45%)
Ache	XP_038945765.1	COesterase	37..563	CDD:395084	163/519 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810