DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est7 and TG

DIOPT Version :9

Sequence 1:	NP_524261.1	Gene:	alpha-Est7 / 40901	FlyBaseID:	FBgn0015575	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_003226.4	Gene:	TG / 7038	HGNCID:	11764	Length:	2768	Species:	Homo sapiens

Alignment Length:	542	Identity:	139/542 - (25%)
Similarity:	223/542 - (41%)	Gaps:	92/542 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 FEGIPYAQPPVGELRFKAPQRPIPWERVRDCSQPKDKAVQVQFVFDKVEG-SEDCLYLNVY-TNN 120
            |.|:|||.||:.|.||:||: |:.|....|.|:|:....|.........| |||||||||: ..|
Human  2228 FLGVPYAAPPLAERRFQAPE-PLNWTGSWDASKPRASCWQPGTRTSTSPGVSEDCLYLNVFIPQN 2291

  Fly   121 VKPDKARPVMVWIHG--------------GGFIIGEANREWYGPDYFMKEDVVLVTIQYRLGALG 171
            |.|:.:  |:|:.|.              |.|:....|             :::||..||:|..|
Human  2292 VAPNAS--VLVFFHNTMDREESEGWPAIDGSFLAAVGN-------------LIVVTASYRVGVFG 2341

  Fly   172 FMSLKSPELNVPGNAGLKDQVLALKWIKNNCASFGGDPNCITVFGESAGG--ASTHYMMLTDQTQ 234
            |:|..|.|  |.||.||.|||.||.|::.:...|||||..:::..:..|.  ||.|.:.......
Human  2342 FLSSGSGE--VSGNWGLLDQVAALTWVQTHIRGFGGDPRRVSLAADRGGADVASIHLLTARATNS 2404

  Fly   235 GLFHRGILQSGSAICPWAYNGDITH-----NPYRIAKLVGYKGEDNDKDVLEFLQNVKAKDLIRV 294
            .||.|.:|..|||:.|.|.   |:|     ....:||.|... ..:.::|:..|:...|..|...
Human  2405 QLFRRAVLMGGSALSPAAV---ISHERAQQQAIALAKEVSCP-MSSSQEVVSCLRQKPANVLNDA 2465

  Fly   295 EENVLTLEERMNKIMFAFGPSLEPFSTPECVISKPPKEMMKTAWSNSIPMFIGNTSYEGLL-WVP 358
            :..:|.:....:    .:||.::..     .:.:||...:|.:....:.:.||::..:||: ...
Human  2466 QTKLLAVSGPFH----YWGPVIDGH-----FLREPPARALKRSLWVEVDLLIGSSQDDGLINRAK 2521

  Fly   359 EVKLMPQVLQQLDAGTPFIP--KELLATEPSKEKLD---SWSAQIRDVHRTGSESTPDNYMDLCS 418
            .||...:...:..:.|.|..  :..|..|.|..:::   :|...:.  |.|...::....::..:
Human  2522 AVKQFEESRGRTSSKTAFYQALQNSLGGEDSDARVEAAATWYYSLE--HSTDDYASFSRALENAT 2584

  Fly   419 IYYFVFPALRVVHSRHAYAAGAPVYFY----RYDFDSEELIFPYRIMRLGRGVKGVSHADDLSYQ 479
            ..||:...:..:.|..|..|...|:.|    .|...|.||:...:.      ..|:........|
Human  2585 RDYFIICPIIDMASAWAKRARGNVFMYHAPENYGHGSLELLADVQF------ALGLPFYPAYEGQ 2643

  Fly   480 FSSLLARRLPKESREYRNIERTVGIWTQFAATGNP-----YSEKINGMDTLTIDPVRKS-----D 534
            | ||..:.|..:..:|         ::.|..:|||     :|.|:....|...|.|.::     .
Human  2644 F-SLEEKSLSLKIMQY---------FSHFIRSGNPNYPYEFSRKVPTFATPWPDFVPRAGGENYK 2698

  Fly   535 EVIKCLNISDDLKFIDLPEWPK 556
            |..:.|.....||..|...|.|
Human  2699 EFSELLPNRQGLKKADCSFWSK 2720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est7	NP_524261.1	COesterase	27..514	CDD:278561	125/488 (26%)
alpha-Est7	NP_524261.1	Aes	<116..>221	CDD:223730	36/119 (30%)
TG	NP_003226.4	TY	33..92	CDD:238114
		TY	95..160	CDD:238114
		TY	300..358	CDD:238114
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	521..545
		Thyroglobulin_1	599..658	CDD:395039
		Thyroglobulin_1	662..724	CDD:395039
		TY	729..>776	CDD:412186
		TY	<892..922	CDD:412186
		TY	1004..1073	CDD:238114
		TY	1077..1145	CDD:238114
		TY	1149..1210	CDD:238114
		Type II. /evidence=ECO:0000269\|PubMed:8797845	1456..1469
		Ephrin_rec_like	1465..1510	CDD:400166
		Type II. /evidence=ECO:0000269\|PubMed:8797845	1470..1486
		Type II. /evidence=ECO:0000269\|PubMed:8797845	1487..1503
		TY	1520..1567	CDD:214561
		Type IIIA. /evidence=ECO:0000269\|PubMed:8797845	1603..1723
		Type IIIB. /evidence=ECO:0000269\|PubMed:8797845	1724..1892
		Type IIIA. /evidence=ECO:0000269\|PubMed:8797845	1893..1995
		Type IIIB. /evidence=ECO:0000269\|PubMed:8797845	1996..2129
		Type IIIA. /evidence=ECO:0000269\|PubMed:8797845	2130..2187
		Cholinesterase-like (ChEL). /evidence=ECO:0000250\|UniProtKB:O08710	2188..2768		139/542 (26%)
		COesterase	2197..2718	CDD:395084	137/538 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2727..2768
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142803
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930