DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est7 and LOC679149

DIOPT Version :9

Sequence 1:	NP_524261.1	Gene:	alpha-Est7 / 40901	FlyBaseID:	FBgn0015575	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_001094469.1	Gene:	LOC679149 / 679149	RGDID:	1591847	Length:	561	Species:	Rattus norvegicus

Alignment Length:	586	Identity:	181/586 - (30%)
Similarity:	271/586 - (46%)	Gaps:	121/586 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 QYRQSTNETVVADTEYGQVRG-IKRLSLYDVPYFSFEGIPYAQPPVGELRFKAPQRPIPWERVRD 87
            |.:.|...:.:.:|..||||| :..:........:|.|||:|:||||.|||..|:.|.||..|||
  Rat    25 QGQHSPESSPIRNTHIGQVRGKLDHVKDTKAGVHTFLGIPFAKPPVGPLRFAPPEAPEPWSGVRD 89

  Fly    88 -CSQP-----------KDKAVQVQFVFDKVEGSEDCLYLNVYTNNVKPDKAR-----PVMVWIHG 135
             .|||           .:...:::.....|..||||||||:|.    |..|.     ||||||||
  Rat    90 GTSQPAMCLQNLDVINAEGLKEMKLKLPPVSMSEDCLYLNIYA----PAHAHEGSNLPVMVWIHG 150

  Fly   136 GGFIIGEANREWYGPDYFMKEDVVLVTIQYRLGALGFMSLKSPELNVPGNAGLKDQVLALKWIKN 200
            ||.:.|.|:. :.|....:.||:|:||||||||.|||.|  :.:.:..||.|..|||.||:|::.
  Rat   151 GGLMTGMASM-YDGSLLTVNEDLVVVTIQYRLGVLGFFS--TGDEHARGNWGYLDQVAALRWVQQ 212

  Fly   201 NCASFGGDPNCITVFGESAGG--ASTHYMMLTDQTQGLFHRGILQSGSAICPWAYNGDITHNPYR 263
            |.|.|||:|:.:|:|||||||  .|||  :::..:|||||..|::||.|:.|:............
  Rat   213 NIAHFGGNPDRVTIFGESAGGTCVSTH--VVSPMSQGLFHGAIMESGVALLPYLIADTSEMFSTM 275

  Fly   264 IAKLVGYKGEDNDKDVLEFLQNVKAKDLIRVEENVLTLEERMNKIMFAFGPSLEPFSTPECVISK 328
            :||:.|.:..|::    ..:..::||.    |..:|.:    ||::     .:.|.......:.:
  Rat   276 VAKVSGCEAMDSE----ALVHCLRAKS----EAEILAI----NKVV-----QMVPAVVDGEFLPR 323

  Fly   329 PPKEMMKTAWSNSIPMFIG--NTSYEGLLW-VPEVKLMPQVLQQLD-AGTPFIPKE-----LLAT 384
            .|||::.:.....:|..||  |..|.   | :|.|....|::::|. .....|.|:     :|..
  Rat   324 HPKELLASEDFRPVPSIIGVNNDEYG---WTIPLVMGTTQMIKELSRENLQAILKKTTAQLMLPL 385

  Fly   385 EPSKEKLDSWSAQIRDVHRTGSESTPDNYMDLCSIYYFVFPALRVVHSRHAYAAGAPVYFYRYDF 449
            |.|...::.:...|.|     .::....:.:|...:.||.|||:|.|.:.::   ||||||.:
  Rat   386 ECSDLLMEEYMGDIED-----PKTLQAQFTELMEDFMFVIPALQVAHFQCSH---APVYFYEF-- 440

  Fly   450 DSEELIF------PYRIMRLGRGVKGVSHADDLSYQF--------------SSLLARRLPKESRE 494
             ..::.|      |:        || ..|.|::.:.|              ..||:||:.|
  Rat   441 -QHQITFLKDIRPPH--------VK-ADHGDEIPFVFGYFFWDMKTDFTEEEKLLSRRMMK---- 491

  Fly   495 YRNIERTVGIWTQFAATGNPYSEKINGMDTLTIDPVRKSDEVIKCLN----ISDDLKFIDLPEWP 555
                     .|..||..|||.||      .|:..||...|:....|:    :...||...|..|.
  Rat   492 ---------YWANFARHGNPNSE------GLSYWPVMDHDQQYLQLDTQPAVGRALKARRLQFWT 541

  Fly   556 K 556
            |
  Rat   542 K 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est7	NP_524261.1	COesterase	27..514	CDD:278561	166/535 (31%)
alpha-Est7	NP_524261.1	Aes	<116..>221	CDD:223730	52/109 (48%)
LOC679149	NP_001094469.1	COesterase	31..540	CDD:278561	177/576 (31%)
LOC679149	NP_001094469.1	Aes	<130..>233	CDD:223730	52/109 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336323
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.640