DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est7 and Bche

DIOPT Version :9

Sequence 1:	NP_524261.1	Gene:	alpha-Est7 / 40901	FlyBaseID:	FBgn0015575	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_075231.1	Gene:	Bche / 65036	RGDID:	619996	Length:	597	Species:	Rattus norvegicus

Alignment Length:	580	Identity:	169/580 - (29%)
Similarity:	270/580 - (46%)	Gaps:	91/580 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 RQSTNETVVADTEYGQVRGIKRLSLYDVPYFSFEGIPYAQPPVGELRFKAPQRPIPWERV----- 85
            :..|.|.|:..|:.|:|||:. :.:......:|.||||||||:|.||||.||....|..|
  Rat    20 KSHTEEDVIITTKTGRVRGLS-MPILGGTVTAFLGIPYAQPPLGSLRFKKPQPLNKWPDVYNATK 83

  Fly    86 --RDCSQPKDKAVQVQFVFDKVEG----------SEDCLYLNVYTNNVKPDKARPVMVWIHGGGF 138
              ..|.|..|:|      |...:|          |||||||||:....||..| .||||::||||
  Rat    84 YANSCYQNIDQA------FPGFQGSEMWNPNTNLSEDCLYLNVWIPVPKPKNA-TVMVWVYGGGF 141

  Fly   139 IIGEANREWYGPDYFMK-EDVVLVTIQYRLGALGFMSLKSPELNVPGNAGLKDQVLALKWIKNNC 202
            ..|.::...|...:..: |.|::|::.||:|||||::... ....|||.||.||.|||:||:.|.
  Rat   142 QTGTSSLPVYDGKFLTRVERVIVVSMNYRVGALGFLAFPG-NSEAPGNMGLFDQQLALQWIQRNI 205

  Fly   203 ASFGGDPNCITVFGESAGGASTHYMMLTDQTQGLFHRGILQSGSAICPWA--YNGDITHNPYRIA 265
            |:|||:|..:|:||||||.||....:|..|:..||.|.||:|||:..|||  :..:..:....:|
  Rat   206 AAFGGNPKSVTLFGESAGAASVSLHLLCPQSYPLFTRAILESGSSNAPWAVKHPEEARNRTLTLA 270

  Fly   266 KLVGYKGEDNDKDVLEFLQNVKAKDLIRVEENVLTLEERMNKIMFAFGPSLE-PFSTPECVISKP 329
            |.:|. .::|:|:::..|::...::::..|:.||..:...:   ..|||::: .|      ::..
  Rat   271 KFIGC-SKENEKEIITCLRSKDPQEILLNEKLVLPSDSIRS---INFGPTVDGDF------LTDM 325

  Fly   330 PKEMMKTAWSNSIPMFIGNTSYEGLLWVPEVKLMPQVLQQLDAGTPFIPKE---LLATEPSKEKL 391
            |..:::.....:..:.:|....||..:             |..|.|...|:   |:.....:|.|
  Rat   326 PHTLLQLGKVKTAQILVGVNKDEGTAF-------------LVYGAPGFSKDNDSLITRREFQEGL 377

  Fly   392 DSWSAQIRDVHRTG---------SESTPDNYM----DLCSIYYFVFPALRVVHSRHAYAAGAPVY 443
            :.:...:..:.:..         .:.||:.|.    |:...|..:.|||............|  :
  Rat   378 NMYFPGVSSLGKEAILFYYVDWLGDQTPEVYREAFDDIIGDYNIICPALEFTKKFAELEINA--F 440

  Fly   444 FYRYDFDSEELIFPYRIMRLGRGVKGVSHADDLSYQFSSLLARRLPKESRE---YRNIERTVGIW 505
            ||.::..|.:|.:|..:        ||.|..::.:.|...|.||:.....|   .|:|.:|   |
  Rat   441 FYYFEHRSSKLPWPEWM--------GVMHGYEIEFVFGLPLERRVNYTRAEEIFSRSIMKT---W 494

  Fly   506 TQFAATGNPYSEKINGMDTLTIDPVRKSDEVIKCLNISDDLKFIDLP-EWPKLKVWESLY 564
            ..||..|:|...:.|.    |:.||..|.|. |.|.::.:...|:.. ..|:.:.|...:
  Rat   495 ANFAKYGHPNGTQGNS----TVWPVFTSTEQ-KYLTLNTEKSKINSKLRAPQCQFWRLFF 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est7	NP_524261.1	COesterase	27..514	CDD:278561	157/526 (30%)
alpha-Est7	NP_524261.1	Aes	<116..>221	CDD:223730	48/105 (46%)
Bche	NP_075231.1	COesterase	21..545	CDD:278561	168/573 (29%)
		Aes	<120..>272	CDD:223730	65/153 (42%)
		AChE_tetra	560..594	CDD:285837
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810