Protein Alignment alpha-Est7 and NLGN4X

DIOPT Version :10

• Sequence 1: NP_524261.1
• Gene: alpha-Est7 / 40901
• FlyBaseID: FBgn0015575
• Length: 572
• Species: Drosophila melanogaster
• Sequence 2: XP_005274621.1
• Gene: NLGN4X / 57502
• HGNCID: 14287
• Length: 836
• Species: Homo sapiens
• Alignment Length: 622
• Identity: 159/622 - (25%)
• Similarity: 256/622 - (41%)
• Gaps: 170/622 - (27%)

  Fly    34 VADTEYGQVRGIKRLSLYDV--PYFSFEGIPYAQPPVGELRFKAPQRPIPWERVRD-------CS 89
            |.:|.||::||::.....::  |...:.|:|||.||.||.||:.|:.|..|..:|:       |.
Human    47 VVNTNYGKIRGLRTPLPNEILGPVEQYLGVPYASPPTGERRFQPPEPPSSWTGIRNTTQFAAVCP 111

  Fly    90 QPKDKA----------------VQVQFVFDKVEGSEDCLYLNVY----------------TNNVK 122
            |..|:.                ..:.:|.|:   :|||||||:|                |:|.:
Human   112 QHLDERSLLHDMLPIWFTANLDTLMTYVQDQ---NEDCLYLNIYVPTEDGANTKKNADDITSNDR 173

  Fly   123 --------PDKARPVMVWIHGGGFIIGEANR------EWYGPDYFMKEDVVLVTIQYRLGALGFM 173
                    .:..:||||:||||.::.|..|.      ..||       :|:::||.||||.|||:
Human   174 GEDEDIHDQNSKKPVMVYIHGGSYMEGTGNMIDGSILASYG-------NVIVITINYRLGILGFL 231

  Fly   174 SLKSPELNVPGNAGLKDQVLALKWIKNNCASFGGDPNCITVFGESAGGASTHYMMLTDQTQGLFH 238
            |  :.:....||.||.||:.||:||:.|..:|||||..:|:||..||.:....:.|:..::|||.
Human   232 S--TGDQAAKGNYGLLDQIQALRWIEENVGAFGGDPKRVTIFGSGAGASCVSLLTLSHYSEGLFQ 294

  Fly   239 RGILQSGSAICPWAYNGDITHNPYRIAKLVGYKGEDN---DKDVLEFLQNVKAKDLIRVEENVLT 300
            :.|:|||:|:..||.|    :.|.:..:::..|...|   ..|::|.|:|...|:||:......|
Human   295 KAIIQSGTALSSWAVN----YQPAKYTRILADKVGCNMLDTTDMVECLRNKNYKELIQQTITPAT 355

  Fly   301 LEERMNKIMFAFGPSLEPFSTPECVISKPPKEMMKTAWSNSIPMFIGNTSYEGLLWVPEVKLMPQ 365
            ..       .||||.::     ..||...|:.:|:.....:..:.:|....|||      |.:..
Human   356 YH-------IAFGPVID-----GDVIPDDPQILMEQGEFLNYDIMLGVNQGEGL------KFVDG 402

  Fly   366 VLQQLDAGTP---------FIP--------KELLATEPSKEKLDSWSAQIRDVHRTGSESTPDNY 413
            ::...|..||         |:.        |:.| .|..|.....|:      .:...|:.....
Human   403 IVDNEDGVTPNDFDFSVSNFVDNLYGYPEGKDTL-RETIKFMYTDWA------DKENPETRRKTL 460

  Fly   414 MDLCSIYYFVFPALRV--VHSRHAYAAGAPVYFYRYDFDSEELIFPYRIMRLGRGVKGVSHADDL 476
            :.|.:.:.:|.||:..  :|:::    |:|.|||.:....:..:.|        .....:|.|::
Human   461 VALFTDHQWVAPAVATADLHAQY----GSPTYFYAFYHHCQSEMKP--------SWADSAHGDEV 513

  Fly   477 SYQF-------SSLLARRLPKESREYRNIERTVGIWTQFAATGNPYSEKINGMDTLTIDPVRKSD 534
            .|.|       :.|.:....|.......:..|  .||.||.||:|...
Human   514 PYVFGIPMIGPTELFSCNFSKNDVMLSAVVMT--YWTNFAKTGDPNQP----------------- 559

  Fly   535 EVIKCLNISDDLKFI-------DLPEWPKLKVWESLY 564
                   :..|.|||       :...|.|....:.||
Human   560 -------VPQDTKFIHTKPNRFEEVAWSKYNPKDQLY 589

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est7	NP_524261.1	COesterase	34..514	CDD:395084	150/563 (27%)
NLGN4X	XP_005274621.1	COesterase	44..610	CDD:395084	159/622 (26%)