Protein Alignment alpha-Est7 and NLGN3

DIOPT Version :10

• Sequence 1: NP_524261.1
• Gene: alpha-Est7 / 40901
• FlyBaseID: FBgn0015575
• Length: 572
• Species: Drosophila melanogaster
• Sequence 2: NP_851820.1
• Gene: NLGN3 / 54413
• HGNCID: 14289
• Length: 848
• Species: Homo sapiens
• Alignment Length: 646
• Identity: 174/646 - (26%)
• Similarity: 262/646 - (40%)
• Gaps: 183/646 - (28%)

  Fly    26 RQSTNETV-VADTEYGQVRGIKRLSLYDV--PYFSFEGIPYAQPPVGELRFKAPQRPIPWERVRD 87
            |.||.... ..:|.:|::||.:.....::  |...:.|:|||.||:||.||..|:.|..|..:|:
Human    34 RASTQAPAPTVNTHFGKLRGARVPLPSEILGPVDQYLGVPYAAPPIGEKRFLPPEPPPSWSGIRN 98

  Fly    88 -------CSQPKDKAV-----QVQFV--FDKV-----EGSEDCLYLNVY--TNNV---------K 122
                   |.|....||     .|.|.  .|.|     |.:|||||||||  |.:|         |
Human    99 ATHFPPVCPQNIHTAVPEVMLPVWFTANLDIVATYIQEPNEDCLYLNVYVPTEDVKRISKECARK 163

  Fly   123 PDK--------------------------------ARPVMVWIHGGGFIIGEANR------EWYG 149
            |:|                                |:||||:||||.::.|..|.      ..||
Human   164 PNKKICRKGGSGAKKQGEDLADNDGDEDEDIRDSGAKPVMVYIHGGSYMEGTGNMIDGSILASYG 228

  Fly   150 PDYFMKEDVVLVTIQYRLGALGFMSLKSPELNVPGNAGLKDQVLALKWIKNNCASFGGDPNCITV 214
                   :|:::|:.||:|.|||:|  :.:....||.||.||:.||:|:..|.|.|||||..|||
Human   229 -------NVIVITLNYRVGVLGFLS--TGDQAAKGNYGLLDQIQALRWVSENIAFFGGDPRRITV 284

  Fly   215 FGESAGGASTHYMMLTDQTQGLFHRGILQSGSAICPWAYNGDITHNPYRIAKLVGYKGEDN---D 276
            ||...|.:....:.|:..::|||.|.|:|||||:..||.|    :.|.:...|:..|...|   .
Human   285 FGSGIGASCVSLLTLSHHSEGLFQRAIIQSGSALSSWAVN----YQPVKYTSLLADKVGCNVLDT 345

  Fly   277 KDVLEFLQNVKAKDLIRVEENVLTLEERMNKIMFAFGPSLEPFSTPECVISKPPKEMMKTAWSNS 341
            .|:::.|:...||:|  ||:::     :..:...||||.::     ..||...|:.:|:.....:
Human   346 VDMVDCLRQKSAKEL--VEQDI-----QPARYHVAFGPVID-----GDVIPDDPEILMEQGEFLN 398

  Fly   342 IPMFIGNTSYEGLLWVPEVKLMPQVLQQLD--AGTPF-------------IP--KELLATEPSKE 389
            ..:.:|....|||      |.:..|:...|  :||.|             .|  |:.| .|..|.
Human   399 YDIMLGVNQGEGL------KFVEGVVDPEDGVSGTDFDYSVSNFVDNLYGYPEGKDTL-RETIKF 456

  Fly   390 KLDSWSAQIRDVHRTGSESTPDNYMDLCSIYYFVFPALRV--VHSRHAYAAGAPVYFYRYDFDSE 452
            ....|:      .|...|:.....:.|.:.:.:|.|::..  :|:|:    |:|.|||.:....:
Human   457 MYTDWA------DRDNPETRRKTLVALFTDHQWVEPSVVTADLHARY----GSPTYFYAFYHHCQ 511

  Fly   453 ELIFPYRIMRLGRGVKGVSHADDLSYQF-------SSLLARRLPKESREYRNIERTVGIWTQFAA 510
            .|:.|        .....:|.|::.|.|       :.|......|.......:..|  .||.||.
Human   512 SLMKP--------AWSDAAHGDEVPYVFGVPMVGPTDLFPCNFSKNDVMLSAVVMT--YWTNFAK 566

  Fly   511 TGNPYSEKINGMDTLTIDPVRKSDEVIKCLNISDDLKFI-------DLPEWPKLKVWESLY 564
            ||:|...                        :..|.|||       :...|.|....:.||
Human   567 TGDPNKP------------------------VPQDTKFIHTKANRFEEVAWSKYNPRDQLY 603

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est7	NP_524261.1	COesterase	34..514	CDD:395084	162/578 (28%)
NLGN3	NP_851820.1	COesterase	40..624	CDD:395084	171/640 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	170..195		0/24 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	645..694