Protein Alignment alpha-Est7 and ACHE

DIOPT Version :10

• Sequence 1: NP_524261.1
• Gene: alpha-Est7 / 40901
• FlyBaseID: FBgn0015575
• Length: 572
• Species: Drosophila melanogaster
• Sequence 2: NP_001354847.1
• Gene: ACHE / 43
• HGNCID: 108
• Length: 681
• Species: Homo sapiens
• Alignment Length: 562
• Identity: 168/562 - (29%)
• Similarity: 251/562 - (44%)
• Gaps: 121/562 - (21%)

  Fly    40 GQVRGIKRLSLYDVPYFSFEGIPYAQPPVGELRFKAPQRPIPWERVRDCSQPKDKAVQ-VQFVFD 103
            |::||| ||.....|..:|.|||:|:||:|..||..|:...||..|.|.:..:....| |..::.
Human   113 GRLRGI-RLKTPGGPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYP 176

  Fly   104 KVEG----------SEDCLYLNVYTNNVKPDKARPVMVWIHGGGFIIGEANREWYGPDYFMK-ED 157
            ..||          |||||||||:|...:|....||:|||:||||..|.::.:.|...:.:: |.
Human   177 GFEGTEMWNPNRELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAER 241

  Fly   158 VVLVTIQYRLGALGFMSLKSPELNVPGNAGLKDQVLALKWIKNNCASFGGDPNCITVFGESAGGA 222
            .|||::.||:||.||::|.... ..|||.||.||.|||:|::.|.|:|||||..:|:||||||.|
Human   242 TVLVSMNYRVGAFGFLALPGSR-EAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAA 305

  Fly   223 STHYMMLTDQTQGLFHRGILQSGSAICPWAY--NGDITHNPYRIAKLVGYK---GEDNDKDVLEF 282
            |....:|:..::|||||.:||||:...|||.  .|:......::|.|||..   ...||.:::..
Human   306 SVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTELVAC 370

  Fly   283 LQNVKAKDLIRVEENVLTLEERMNKIMFAFGPSLE-PFSTPECVISKPPKEMMKTAWSNSIPMFI 346
            |:...|:.|:..|.:||..|   :...|:|.|.:: .|      :|..|:.::.....:.:.:.:
Human   371 LRTRPAQVLVNHEWHVLPQE---SVFRFSFVPVVDGDF------LSDTPEALINAGDFHGLQVLV 426

  Fly   347 GNTSYEGLLWVPEVKLMPQVLQQLDAGTPFIPKELLATEPSKEKLDSWSAQIRDVHRTGSESTPD 411
            |....||..:             |..|.|...|:       .|.|.|.:..:..| |.|.....|
Human   427 GVVKDEGSYF-------------LVYGAPGFSKD-------NESLISRAEFLAGV-RVGVPQVSD 470

  Fly   412 NYMDLCSIYY--FVFP--------ALRVVHSRH------------AYAAGAPVYFYRYDFDSEEL 454
            ...:...::|  ::.|        ||..|...|            ..|.||.||.|.::..:..|
Human   471 LAAEAVVLHYTDWLHPEDPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTL 535

  Fly   455 IFPYRIMRLGRGVKGVSHADDLSYQFSSLLARRLPKE-SREYRNIE-----RTVGIWTQFAATGN 513
            .:|..:        ||.|..::.:.|.      :|.: ||.|...|     |.:..|..||.||:
Human   536 SWPLWM--------GVPHGYEIEFIFG------IPLDPSRNYTAEEKIFAQRLMRYWANFARTGD 586

  Fly   514 PYSEKINGMDTLTIDPVRKSDEVIKCLNISDDLKFIDLPEWP 555
            |...:         ||                    ..|:||
Human   587 PNEPR---------DP--------------------KAPQWP 599

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est7	NP_524261.1	COesterase	34..514	CDD:395084	162/519 (31%)
ACHE	NP_001354847.1	COesterase	104..630	CDD:395084	168/562 (30%)
		AChE_tetra	645..678	CDD:430146