DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est7 and ACHE

DIOPT Version :9

Sequence 1:	NP_524261.1	Gene:	alpha-Est7 / 40901	FlyBaseID:	FBgn0015575	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_001354847.1	Gene:	ACHE / 43	HGNCID:	108	Length:	681	Species:	Homo sapiens

Alignment Length:	562	Identity:	168/562 - (29%)
Similarity:	251/562 - (44%)	Gaps:	121/562 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 GQVRGIKRLSLYDVPYFSFEGIPYAQPPVGELRFKAPQRPIPWERVRDCSQPKDKAVQ-VQFVFD 103
            |::||| ||.....|..:|.|||:|:||:|..||..|:...||..|.|.:..:....| |..::.
Human   113 GRLRGI-RLKTPGGPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYP 176

  Fly   104 KVEG----------SEDCLYLNVYTNNVKPDKARPVMVWIHGGGFIIGEANREWYGPDYFMK-ED 157
            ..||          |||||||||:|...:|....||:|||:||||..|.::.:.|...:.:: |.
Human   177 GFEGTEMWNPNRELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAER 241

  Fly   158 VVLVTIQYRLGALGFMSLKSPELNVPGNAGLKDQVLALKWIKNNCASFGGDPNCITVFGESAGGA 222
            .|||::.||:||.||::|.... ..|||.||.||.|||:|::.|.|:|||||..:|:||||||.|
Human   242 TVLVSMNYRVGAFGFLALPGSR-EAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAA 305

  Fly   223 STHYMMLTDQTQGLFHRGILQSGSAICPWAY--NGDITHNPYRIAKLVGYK---GEDNDKDVLEF 282
            |....:|:..::|||||.:||||:...|||.  .|:......::|.|||..   ...||.:::..
Human   306 SVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTELVAC 370

  Fly   283 LQNVKAKDLIRVEENVLTLEERMNKIMFAFGPSLE-PFSTPECVISKPPKEMMKTAWSNSIPMFI 346
            |:...|:.|:..|.:||..|   :...|:|.|.:: .|      :|..|:.::.....:.:.:.:
Human   371 LRTRPAQVLVNHEWHVLPQE---SVFRFSFVPVVDGDF------LSDTPEALINAGDFHGLQVLV 426

  Fly   347 GNTSYEGLLWVPEVKLMPQVLQQLDAGTPFIPKELLATEPSKEKLDSWSAQIRDVHRTGSESTPD 411
            |....||..:             |..|.|...|:       .|.|.|.:..:..| |.|.....|
Human   427 GVVKDEGSYF-------------LVYGAPGFSKD-------NESLISRAEFLAGV-RVGVPQVSD 470

  Fly   412 NYMDLCSIYY--FVFP--------ALRVVHSRH------------AYAAGAPVYFYRYDFDSEEL 454
            ...:...::|  ::.|        ||..|...|            ..|.||.||.|.::..:..|
Human   471 LAAEAVVLHYTDWLHPEDPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTL 535

  Fly   455 IFPYRIMRLGRGVKGVSHADDLSYQFSSLLARRLPKE-SREYRNIE-----RTVGIWTQFAATGN 513
            .:|..:        ||.|..::.:.|.      :|.: ||.|...|     |.:..|..||.||:
Human   536 SWPLWM--------GVPHGYEIEFIFG------IPLDPSRNYTAEEKIFAQRLMRYWANFARTGD 586

  Fly   514 PYSEKINGMDTLTIDPVRKSDEVIKCLNISDDLKFIDLPEWP 555
            |...:         ||                    ..|:||
Human   587 PNEPR---------DP--------------------KAPQWP 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est7	NP_524261.1	COesterase	27..514	CDD:278561	162/519 (31%)
alpha-Est7	NP_524261.1	Aes	<116..>221	CDD:223730	49/105 (47%)
ACHE	NP_001354847.1	COesterase	104..630	CDD:395084	168/562 (30%)
ACHE	NP_001354847.1	AChE_tetra	645..678	CDD:400834
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142769
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.740