DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est7 and CG10175

DIOPT Version :9

Sequence 1:	NP_524261.1	Gene:	alpha-Est7 / 40901	FlyBaseID:	FBgn0015575	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_001287487.1	Gene:	CG10175 / 42773	FlyBaseID:	FBgn0039084	Length:	707	Species:	Drosophila melanogaster

Alignment Length:	589	Identity:	206/589 - (34%)
Similarity:	306/589 - (51%)	Gaps:	66/589 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LKTIEHKVQQYRQSTNETVVADTEYGQVRGIKRLSLYDV----PYFSFEGIPYAQPPVGELRFKA 75
            ::.::..|:..|:  ...:||.|..|:|||  |...|..    .|:||:|:.|..||.|..||:|
  Fly   138 MRVVQEVVRSLRK--EREIVATTSLGKVRG--RYQKYRSGERGGYYSFKGMRYGAPPTGARRFRA 198

  Fly    76 PQRPIPWERVRDCSQPKDKAVQVQFVFDKVEGSEDCLYLNVYTNNV-KPDKAR-----PVMVWIH 134
            .:...||..:||.|:..........:.|..:|.||||::||:|..: |.|::.     |||||:|
  Fly   199 AEPEKPWSGIRDASREGQSCPHKNMILDTFKGDEDCLFVNVFTTQMPKDDESAEQPKLPVMVWLH 263

  Fly   135 GGGFIIGEANREWYGPDYFMKEDVVLVTIQYRLGALGFMSLKSPELNVPGNAGLKDQVLALKWIK 199
            ||||..|..|...|||||.:.||:||||:.||||.|||:: ..|:  .|||.|||||||||||::
  Fly   264 GGGFSFGSGNSFLYGPDYLVAEDIVLVTLNYRLGPLGFLT-AGPD--APGNQGLKDQVLALKWVR 325

  Fly   200 NNCASFGGDPNCITVFGESAGGASTHYMMLTDQTQGLFHRGILQSGSAICPWAYNGDITHNPYRI 264
            :|.|:||||||.:|:||||||.:|...::|:.|.:|||||.|.|||||:.||:.:...:....|:
  Fly   326 DNIAAFGGDPNQVTIFGESAGASSVQLLLLSSQAKGLFHRAISQSGSALNPWSMSASSSQRAARL 390

  Fly   265 AKLVGYKGEDNDKDVLEFLQNVKAKDLIRVEENVLTLEERMNKIMFAFGPSLEPF----STPECV 325
            |..:||.|.:..:|:|:||:.|.|..|:......:|.|::.|.|...|.|.:|.:    |..|..
  Fly   391 AANLGYVGANKTEDILDFLRRVPAMKLVEAAPTTITAEDQRNNIGLPFVPVVEGYWNQDSQEEQF 455

  Fly   326 ISKP-----PKEMMKTAWSNS-IPMFIGNTSYEGLLWVPEVKLMPQVLQ--QLDAGTPFIPKELL 382
            ..:|     |.:|..:...|| :....|..::|.:|::..::..||:|.  :.|.|. .:|::|.
  Fly   456 YEEPFLTQHPSDMYHSQNFNSDVAYMTGYNTHEAMLFIRRLRKNPQLLSIIENDFGR-LVPQDLN 519

  Fly   383 ATEPSKEKLDSWSAQIRDVH----RTGSESTPDNYMDLCSIYYFVFPALRVVHSRHAYAAGAPVY 443
            .||..    |..:.:||..:    ..|.||. |..:.|.:...|: ..:|.....||....||||
  Fly   520 VTESH----DRVTREIRSFYLGSKHVGIESV-DEMIALLTDLMFL-QGIRRTARNHAKFGNAPVY 578

  Fly   444 FYRYDFDSEELIFPYRIMRLGRGVKGVSHADDLSYQFS-SLLARRLPKESREYRNIERTVGIWTQ 507
            .||:.||..  :..|:.| ||....||.|.|:|.|.|. ......|..:|.|.:...|.|.:||.
  Fly   579 MYRFSFDGS--LGLYKRM-LGIPRPGVCHGDELGYLFKFGFFNLSLDPKSMEVQVKNRMVRMWTN 640

  Fly   508 FAATGNPYSEKINGMDT---LTIDPVRKSDEVIKCLNISDDLKFIDL---------PEWPKLKVW 560
            ||..|:|..:..:.|.|   ..|||.          |:.:.|.::|:         ||..:.:.|
  Fly   641 FAKYGSPTPDSEDPMLTTKWAPIDPT----------NVMNSLNYMDISANLAMKTNPEPERQRFW 695

  Fly   561 ESLY 564
            :.:|
  Fly   696 DEMY 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est7	NP_524261.1	COesterase	27..514	CDD:278561	191/513 (37%)
alpha-Est7	NP_524261.1	Aes	<116..>221	CDD:223730	63/110 (57%)
CG10175	NP_001287487.1	COesterase	157..695	CDD:278561	200/562 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	216	1.000	Inparanoid score	I3612
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	8	7.760