DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est7 and Nlg1

DIOPT Version :9

Sequence 1:	NP_524261.1	Gene:	alpha-Est7 / 40901	FlyBaseID:	FBgn0015575	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_001246966.1	Gene:	Nlg1 / 40913	FlyBaseID:	FBgn0051146	Length:	1354	Species:	Drosophila melanogaster

Alignment Length:	577	Identity:	158/577 - (27%)
Similarity:	237/577 - (41%)	Gaps:	148/577 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 HKVQQYRQSTNETVVADTEYGQVRGIKR-------LSLYDVPYFSFEGIPYAQPPVGELRFKAPQ 77
            |.|....|.|.|..|   :.|::.||.|       |...|    .|.|:|||:.|.|..||..|.
  Fly   146 HVVPDKLQYTQEIQV---KQGRLMGITRRFQVTSGLRQVD----QFLGLPYAEAPTGNRRFMPPG 203

  Fly    78 RPIPWERVR----------------------DCSQPKDKAVQVQFVFDKVEGSEDCLYLNVYTNN 120
            .|:||:.::                      :.|:.:.|.:.....:.:.| ||||||||:|..:
  Fly   204 APLPWQGLKIARHLPPVCPQKLPDLSPHGSENMSRARHKHLSRLLPYLRTE-SEDCLYLNLYVPH 267

  Fly   121 VKPD---KARPVMVWIHGGGFIIGEANREW-------------YGPDYFMKEDVVLVTIQYRLGA 169
            .:|.   |...|:|::||..|       ||             ||       :|::||:.||||.
  Fly   268 EEPQSTPKQYAVLVYLHGESF-------EWNSGNPYDGSVLSSYG-------EVIVVTVNYRLGV 318

  Fly   170 LGFMSLKSPELNVPGNAGLKDQVLALKWIKNNCASFGGDPNCITVFGESAGGASTHYMMLTDQTQ 234
            |||:.......|: .|..|.||:.||.|||.|..:||||.:.:|:.|.|.|.|..:|:|::....
  Fly   319 LGFLRPSIDAHNI-ANYALLDQIAALHWIKENIEAFGGDNSRVTLMGHSTGAACVNYLMVSPVAS 382

  Fly   235 GLFHRGILQSGSAICPWAYNGDITHNPYRIAKLV------GYKGEDNDKDVLEFLQNVKAKDLIR 293
            |||||.||.||||:..||.:........:||..:      ..:.||:|. :|:.|::.:.:|::.
  Fly   383 GLFHRAILMSGSAMSDWAASNQSLQLTMQIAHALECPLNEHVEAEDDDV-LLDCLRHRRYQDILH 446

  Fly   294 VEENVLTLEERMNKIMFAFGPSLEPFSTPECVISKPPKEM-MKTAWSNSIPMFIGNT---SY--- 351
            : ...||          .|..||.|......:.::|.|.| ..|...:...:..|.|   ||
  Fly   447 I-PTALT----------QFSTSLGPIVDGHVIPNQPYKVMGHYTEHFSRYDLLFGITESESYHTL 500

  Fly   352 ------EGLLWVPEVKLMPQVLQ-QLDAGTPFIPKELLATEPSKEKLDSWSAQIRDV---HRTGS 406
                  |||.......|:...:| :.|     |..:|......|:..|.::..|:..   ||
  Fly   501 AALALEEGLRENERDNLLRFYMQSRFD-----IRPDLALAATLKKYQDMYNNPIKATNLEHR--- 557

  Fly   407 ESTPDNYMDLCSIYYFVFPALRV------VHSRHAYAAGAPVYFYRYDFDSEELIF---PYRIMR 462
                |..:|:.|....|.|.|:.      |:.|:        |.|.:..:|....|   |:.||
  Fly   558 ----DVVLDILSDARVVGPLLQTGMFHADVNRRN--------YMYVFGHNSATGPFAHLPHSIM- 609

  Fly   463 LGRGVKGVSHADDLSYQFSSLLARRLPKESREYRNIER-----TVGIWTQFAATGNP 514
                      .::|::.|.:.||...|..|..|...|:     .:..||.|..||||
  Fly   610 ----------GEELAFIFGAPLAAAGPFPSGNYTVQEKLLSEAVMAYWTNFVKTGNP 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est7	NP_524261.1	COesterase	27..514	CDD:278561	154/568 (27%)
alpha-Est7	NP_524261.1	Aes	<116..>221	CDD:223730	40/120 (33%)
Nlg1	NP_001246966.1	COesterase	153..710	CDD:278561	156/570 (27%)
Nlg1	NP_001246966.1	Aes	<263..>408	CDD:223730	57/159 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.810