DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est7 and alpha-Est2

DIOPT Version :9

Sequence 1:	NP_524261.1	Gene:	alpha-Est7 / 40901	FlyBaseID:	FBgn0015575	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_001262345.1	Gene:	alpha-Est2 / 40908	FlyBaseID:	FBgn0015570	Length:	566	Species:	Drosophila melanogaster

Alignment Length:	586	Identity:	260/586 - (44%)
Similarity:	369/586 - (62%)	Gaps:	34/586 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNKNLGFVERLRWRLKTIEHKVQQYRQSTNETVVADTEYGQVRGIKRLSLYD-VPYFSFEGIPYA 64
            |...:|:.:.::...:.:.|||||||.||..||:.||:||||||::|.::|| .|||:|||||||
  Fly     1 MEVQVGWPKLIKMGAQLVGHKVQQYRLSTGHTVILDTKYGQVRGLQRKTVYDKEPYFAFEGIPYA 65

  Fly    65 QPPVGELRFKAPQRPIPWERVRDCSQPKDKAVQVQFVFDKVEGSEDCLYLNVYTNNVKPDKARPV 129
            :||||:|||:|||.|.||:.|.:|:..:.|.:|...:...||||||||:||||...:|.:|..||
  Fly    66 KPPVGDLRFRAPQPPEPWQGVLNCTTNRSKPMQRNMLLGIVEGSEDCLHLNVYVKALKSEKPLPV 130

  Fly   130 MVWIHGGGFIIGEANREWYGPDYFMKEDVVLVTIQYRLGALGFMSLKSPELNVPGNAGLKDQVLA 194
            :|||:||||..|||:|:.|.||||||:.||.|.|.|||.||||:|||.|:|:|||||||||||:|
  Fly   131 IVWIYGGGFQKGEASRDIYSPDYFMKKPVVFVAINYRLAALGFLSLKDPKLDVPGNAGLKDQVMA 195

  Fly   195 LKWIKNNCASFGGDPNCITVFGESAGGASTHYMMLTDQTQGLFHRGILQSGSAICPWAYNGDITH 259
            |:||..|.|.|.||||.||:.|||||.||.|.||.|:||:||||:.|:|||.|:..|..:.| .:
  Fly   196 LRWISQNIAHFNGDPNNITLMGESAGSASVHVMMTTEQTRGLFHKAIMQSGCALSEWVESPD-NN 259

  Fly   260 NPYRIAKLVGYKGEDNDKDVLEFLQNVKAKDLIRVEENVLTLEERMNKIMFAFGPSLEPFSTPEC 324
            ..:|:|:.:||||::.|.|||.||..|.|:.:..::::|:.|:|..:.::|||||.:||:.|..|
  Fly   260 WAFRLAQNLGYKGDEKDADVLSFLSKVCARQIAAIDQDVINLDEVRSFLLFAFGPVIEPYETDHC 324

  Fly   325 VISKPPKEMMKTAWSNSIPMFIGNTSYEGLLWVPEVKLMPQVLQQLDAGTPFIPKELLATEPSKE 389
            |:.|..|:::..||.|.||:.:|..|:|||.....|:..|..|:...   ..:|:|:..|    .
  Fly   325 VVPKRHKDLLSEAWGNDIPVIVGGNSFEGLFSYQLVRKDPWALKNFH---NILPREVRET----S 382

  Fly   390 KLDSWSAQIRDVHRTGSESTPDNYMDLCSIYYFVFPAL-------------RVVHSRHAYAAGAP 441
            .|:.....:|.:.:....:.....|::       |.||             |.:.:|.:||...|
  Fly   383 SLEGQDLLVRRLKQLYFNNEMQESMEM-------FEALNIFSHRQIWHDTHRFILARQSYAPKTP 440

  Fly   442 VYFYRYDFDSEELIFPYRIMRLGRGVKGVSHADDLSYQFSSLLARRLPKESREYRNIERTVGIWT 506
            .|.||:||||.. ...:|.:..|..::||:|||:|||.|.:::|.:|.|.|.||:.|||.||:||
  Fly   441 TYLYRFDFDSPH-FNQFRRLVCGDRIRGVAHADELSYLFYNIIASKLDKSSMEYKTIERMVGMWT 504

  Fly   507 QFAATGNPYSEKINGMDTLTIDPVRKSDEVIKCLNISDDLKFIDLPEWPKLKVWESLYDDNKDLL 571
            .||::|||...::.......:.  .|.:.|.||.|||.||:..||||...|.||::.|.  ::.|
  Fly   505 SFASSGNPNCPELGSAKWEAVQ--LKENAVEKCFNISHDLEMRDLPESDCLAVWDTFYP--RESL 565

  Fly   572 F 572
            |
  Fly   566 F 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est7	NP_524261.1	COesterase	27..514	CDD:278561	230/500 (46%)
alpha-Est7	NP_524261.1	Aes	<116..>221	CDD:223730	68/104 (65%)
alpha-Est2	NP_001262345.1	COesterase	32..523	CDD:278561	230/506 (45%)
alpha-Est2	NP_001262345.1	Aes	<117..>221	CDD:223730	67/103 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467353
Domainoid	1	1.000	450	1.000	Domainoid score	I1603
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	492	1.000	Inparanoid score	I3113
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG26273
OrthoDB	1	1.010	-	-		D18817at7147
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	1	1.100	-	-	P	PTHR43142
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	12	11.810