DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est7 and alpha-Est3

DIOPT Version :9

Sequence 1:	NP_524261.1	Gene:	alpha-Est7 / 40901	FlyBaseID:	FBgn0015575	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_001163540.1	Gene:	alpha-Est3 / 40907	FlyBaseID:	FBgn0015571	Length:	543	Species:	Drosophila melanogaster

Alignment Length:	553	Identity:	222/553 - (40%)
Similarity:	322/553 - (58%)	Gaps:	36/553 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 ETVVADTEYGQVRGIKRLSLYDVPYFSFEGIPYAQPPVGELRFKAPQRPIPWERVRDCSQPKDKA 95
            |::..:|..|.|.|.:...:|...|.|||.|||||||||.|||.||....||.:..||::|..|.
  Fly     2 ESLQVNTTSGPVLGKQCTGVYGDEYVSFERIPYAQPPVGHLRFMAPLPVEPWSQPLDCTKPGQKP 66

  Fly    96 VQVQFVFDKVEGSEDCLYLNVYTNNVKPDKARPVMVWIHGGGFIIGEANREWYGPDYFMKEDVVL 160
            :|......::||.|||||||||...:...:..|::|:..||||..|:..:|.:.|||||..|||:
  Fly    67 LQFNHYSKQLEGVEDCLYLNVYAKELDSPRPLPLIVFFFGGGFEKGDPTKELHSPDYFMMRDVVV 131

  Fly   161 VTIQYRLGALGFMSLKSPELNVPGNAGLKDQVLALKWIKNNCASFGGDPNCITVFGESAGGASTH 225
            ||:.||:|.|||:||..|.:.||||||||||:||::|||.|...|.|||..:|.||||||.||.|
  Fly   132 VTVSYRVGPLGFLSLNDPAVGVPGNAGLKDQLLAMEWIKENAERFNGDPKNVTAFGESAGAASVH 196

  Fly   226 YMMLTDQTQGLFHRGILQSGSAICPWAYNGDITHNPYRIAKLVGYKGEDN--DKDVLEFLQNVKA 288
            |:||..:.:||||:.|||||:.:|.||. ..|.:.|:|:|..:|.:..::  |..||:|||.:..
  Fly   197 YLMLNPKAEGLFHKAILQSGNVLCSWAL-CTIKNLPHRLAVNLGMESAEHVTDAMVLDFLQKLPG 260

  Fly   289 KDLIRVEENVLTLEERMNKIMFAFGPSLEPFSTPECVISKPPKEMMKTAWSNSIPMFIGNTSYEG 353
            :.|:|  ..:|:.||.::..:|.|||.:||:.|..|.:...|:|::..||.|.||:.:..||:||
  Fly   261 EKLVR--PYLLSAEEHLDDCVFQFGPMVEPYKTEHCALPNHPQELLDKAWGNRIPVLMSGTSFEG 323

  Fly   354 LLWVPEVKLMPQVLQQLDAGTPFIPKELLATEPSKEKLDSWSA-----QIRDVHRTG---SESTP 410
            ||....|::.|.:|..|...    |:.:|..: .|..|....|     ::::.|..|   |..:|
  Fly   324 LLMYARVQMAPYLLTSLKKE----PEHMLPLD-VKRNLPQALARHLGQRLQETHFGGNDPSAMSP 383

  Fly   411 DN---YMDLCSIYYFVFPALRVVHSRHAYAAGAPVYFYRYDFDSEELIFPY-RIMRLGRGVKGVS 471
            ::   |.:..|...|..|.|:.:.|| ..::.|..|.||:||||.  .|.: |:...|..::||:
  Fly   384 ESLKAYCEYASYKVFWHPILKTLRSR-VKSSSASTYLYRFDFDSP--TFNHQRLKYCGDKLRGVA 445

  Fly   472 HADDLSYQFSSLLARRLPKESREYRNIERTVGIWTQFAATGNPYSEKINGMDTLTIDPVRK---- 532
            |.||.||.:....:.:|.|.:.|:..|||.:.:.|.||.|.||..:.|  .|.|   |..|
  Fly   446 HVDDHSYLWYGDFSWKLDKHTPEFLTIERMIDMLTSFARTSNPNCKLI--QDQL---PRAKEWKP 505

  Fly   533 --SDEVIKCLNISDDLKFIDLPEWPKLKVWESL 563
              |...::|||||:::|.::|||..||:||||:
  Fly   506 LNSKSALECLNISENIKMMELPELQKLRVWESV 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est7	NP_524261.1	COesterase	27..514	CDD:278561	199/496 (40%)
alpha-Est7	NP_524261.1	Aes	<116..>221	CDD:223730	55/104 (53%)
alpha-Est3	NP_001163540.1	Abhydrolase	3..529	CDD:304388	214/541 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467364
Domainoid	1	1.000	222	1.000	Domainoid score	I1478
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	226	1.000	Inparanoid score	I2231
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43142
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	8	7.890