DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est7 and alpha-Est6

DIOPT Version :9

Sequence 1:	NP_524261.1	Gene:	alpha-Est7 / 40901	FlyBaseID:	FBgn0015575	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_524262.1	Gene:	alpha-Est6 / 40902	FlyBaseID:	FBgn0015574	Length:	568	Species:	Drosophila melanogaster

Alignment Length:	560	Identity:	224/560 - (40%)
Similarity:	305/560 - (54%)	Gaps:	52/560 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 ETVVADTEYGQVRGIKRLSLYDVPYFSFEGIPYAQPPVGELRFKAPQRPIPWERVRDCSQPKDKA 95
            ::.|.....|.|:|.:...:|...::||||||:|:||:|:.||.|.|...||....|..|.:...
  Fly    39 DSKVVKLSVGSVKGRRLSGIYGDEFYSFEGIPFAKPPLGKARFVASQLADPWNSELDARQERPIP 103

  Fly    96 VQVQFVFDKVEGSEDCLYLNVYTNNV-KPDKARPVMVWIHGGGFIIGEANREWYGPDYFMKEDVV 159
            :|:.....||.||||||||||||.:. :.:...||||:|:||.|..|.|.:..|||||.|..|||
  Fly   104 LQMDRRSGKVVGSEDCLYLNVYTKHFNESEPPLPVMVYIYGGAFRTGGAVKSKYGPDYLMSRDVV 168

  Fly   160 LVTIQYRLGALGFMSLKSPELNVPGNAGLKDQVLALKWIKNNCASFGGDPNCITVFGESAGGAST 224
            .|...|||.:|||:|:.|.:|:|||||||.||:|||:|:..:..:|.|||..||:||||||.||.
  Fly   169 YVLFNYRLCSLGFLSMPSGKLDVPGNAGLHDQLLALQWVSQHIRNFNGDPQNITLFGESAGAASV 233

  Fly   225 HYMMLTDQTQGLFHRGILQSGSAICPWAYNGDITHNPYRIAKLVGYKGEDNDKDVLEFLQNVKAK 289
            |:||...|.:||||:.|:.|||.:.||....|......|:|...||:|...:..:||||:||.|:
  Fly   234 HFMMCLPQAKGLFHKAIMMSGSMLSPWVNAPDSDGIFCRLATSAGYEGPAEEVPILEFLRNVNAE 298

  Fly   290 DLIRVEENVLTLEERMNKIMFAFGPSLEPFSTPEC--VISKPPKEMMKTAWSNSIPMFIGNTSYE 352
            .||  ..:.::..:|    .|.|   |.||: |..  :::.|.:::||.|||..:|:.:|.||:|
  Fly   299 KLI--GHDFISPRDR----CFGF---LNPFA-PVVGGLVAAPFQQLMKEAWSCEVPLLLGGTSFE 353

  Fly   353 GLLWVPEVKLMPQVLQQLDAGTPFIPKELLATEPS----KEKLDSWSAQIRDV--------H--- 402
            ||::.|        ..|||.|...   |||..||:    .|...|.|.:.|:.        |
  Fly   354 GLVYYP--------FCQLDNGYML---ELLKHEPAMVLPHELYQSMSVEERNTAADVLVKYHYGP 407

  Fly   403 RTGSESTPDNYMDLCSIYYFVFPALRVVHSRHAYAAGAPVYFYRYDFDSEELIFPYRIMR---LG 464
            |..::|.....:||.|...|.....|||.||.::|. ||.|.||:||||.:|    .:||   .|
  Fly   408 RGITKSNITQILDLFSYKLFWHGIHRVVLSRLSHAQ-APTYLYRFDFDSPKL----NLMRNQLCG 467

  Fly   465 RGVK-GVSHADDLSYQFSSLLARRLPKESREYRNIERTVGIWTQFAATGNPYSEKINGMDTLTID 528
            ..:| ||.|||||.|.|......:.|.:|.|:..|:|.|||.|.||.||:|...: .|.|...
  Fly   468 DDIKRGVCHADDLGYIFHKQAQAKQPLDSPEFLTIQRMVGILTTFARTGDPNCPE-TGPDPWM-- 529

  Fly   529 PVRKSDEVIKCLNISDDLKFIDLPEWPKLKVWESLYDDNK 568
            || .:....|.|||...::.:...|...||||..||.|.|
  Fly   530 PV-STKSPFKALNIGQQVECVTQVEKDGLKVWNRLYSDLK 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est7	NP_524261.1	COesterase	27..514	CDD:278561	206/504 (41%)
alpha-Est7	NP_524261.1	Aes	<116..>221	CDD:223730	56/105 (53%)
alpha-Est6	NP_524262.1	COesterase	35..534	CDD:278561	211/524 (40%)
alpha-Est6	NP_524262.1	Aes	<133..325	CDD:223730	92/201 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467375
Domainoid	1	1.000	222	1.000	Domainoid score	I1478
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	226	1.000	Inparanoid score	I2231
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43142
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	10	9.900