DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est7 and Est-6

DIOPT Version :9

Sequence 1:	NP_524261.1	Gene:	alpha-Est7 / 40901	FlyBaseID:	FBgn0015575	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster

Alignment Length:	519	Identity:	152/519 - (29%)
Similarity:	241/519 - (46%)	Gaps:	70/519 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 TNETVVADTEYGQVRGIKRLSLYDVPYFSFEGIPYAQPPVGELRFKAPQRPI--PWERVRDCSQP 91
            |::.::.....|::||....|     |:|:|.||||:||.|:|||:||: |.  .|..:.|.::.
  Fly    24 TDDPLLVQLPQGKLRGRDNGS-----YYSYESIPYAEPPTGDLRFEAPE-PYKQKWSDIFDATKT 82

  Fly    92 KDKAVQ-VQFV--FDKVEGSEDCLYLNVYTNNVKPDKAR----PVMVWIHGGGFIIGEANREWY- 148
            ....:| .||.  .:|:.|.||||.::||    ||..::    ||:..||||.|:.|.|   |.
  Fly    83 PVACLQWDQFTPGANKLVGEEDCLTVSVY----KPKNSKRNSFPVVAHIHGGAFMFGAA---WQN 140

  Fly   149 GPDYFMKE-DVVLVTIQYRLGALGFMSLKSPELNVPGNAGLKDQVLALKWIKNNCASFGGDPNCI 212
            |.:..|:| ..:||.|.||||.|||:|  :.:.::|||.|||||.|||||||.|.|||||:|..:
  Fly   141 GHENVMREGKFILVKISYRLGPLGFVS--TGDRDLPGNYGLKDQRLALKWIKQNIASFGGEPQNV 203

  Fly   213 TVFGESAGGASTHYMMLTDQTQGLFHRGILQSGSAICPWAYNGDITHNPYRIAKLVGYKGEDNDK 277
            .:.|.||||||.|..||.:....|.......||:|:.||..........:.:.:.||.:..::..
  Fly   204 LLVGHSAGGASVHLQMLREDFGQLARAAFSFSGNALDPWVIQKGARGRAFELGRNVGCESAEDST 268

  Fly   278 DVLEFLQNVKAKDLIRVEENVLTLEERMNKIMFA-FGPSLEPFSTPECVISKPPKEMMKTAWSNS 341
            .:.:.|::..|.:|:......|.    .:.:.|| |.|.|||...|:.:|::.|::::|:.....
  Fly   269 SLKKCLKSKPASELVTAVRKFLI----FSYVPFAPFSPVLEPSDAPDAIITQDPRDVIKSGKFGQ 329

  Fly   342 IPMFIG----NTSYEGLLWVPE--------------VKLMPQVLQQLDAGTPFIPKELLATEPSK 388
            :|..:.    :..|...|.:.|              ::|.|.:|...|..|             |
  Fly   330 VPWAVSYVTEDGGYNAALLLKERKSGIVIDDLNERWLELAPYLLFYRDTKT-------------K 381

  Fly   389 EKLDSWSAQIRDVHRTGSESTPDNYMDLCSIYYFVFPALRVVHS--RHAYAAGAPVYFYRYDFDS 451
            :.:|.:|.:|:..:........::|.:|..::..:........|  .|.....:|.|.|.||..:
  Fly   382 KDMDDYSRKIKQEYIGNQRFDIESYSELQRLFTDILFKNSTQESLDLHRKYGKSPAYAYVYDNPA 446

  Fly   452 EELIFPYRIMRLGRGVKGVSHADDLSYQFSSLL--ARRLPKESREYRNIERTVGIWTQFAATGN 513
            |:.|......|..... |..|.||....|.:.:  ....|.|....||.   :.:...||::.|
  Fly   447 EKGIAQVLANRTDYDF-GTVHGDDYFLIFENFVRDVEMRPDEQIISRNF---INMLADFASSDN 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est7	NP_524261.1	COesterase	27..514	CDD:278561	152/519 (29%)
alpha-Est7	NP_524261.1	Aes	<116..>221	CDD:223730	53/110 (48%)
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	151/514 (29%)
Est-6	NP_001261749.1	Aes	<110..>243	CDD:223730	65/141 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440357
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	8	7.790