DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est7 and Ces1b

DIOPT Version :9

Sequence 1:	NP_524261.1	Gene:	alpha-Est7 / 40901	FlyBaseID:	FBgn0015575	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_001074841.1	Gene:	Ces1b / 382044	MGIID:	3779470	Length:	567	Species:	Mus musculus

Alignment Length:	601	Identity:	166/601 - (27%)
Similarity:	252/601 - (41%)	Gaps:	161/601 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 VADTEYGQVRGIKRLSL--YDVPYFSFEGIPYAQPPVGELRFKAPQRPIPWERVRD-------CS 89
            |.||..|::.| |..||  ::.|...|.|:|:|:||:|.|||..|:...||..|::       ||
Mouse    25 VVDTTQGKILG-KYTSLEGFEHPVAVFLGVPFAKPPLGSLRFAPPEPAEPWSFVKNATSYPPMCS 88

  Fly    90 QPKDKAVQVQFVFD----KVEG-----SEDCLYLNVYT-NNVKPDKARPVMVWIHGGGFIIGEAN 144
            |   .||.||.:.|    |.|.     ||||||||:|: .::......||||||||||.:.|.|:
Mouse    89 Q---DAVAVQLLSDMLSTKKESIPPLFSEDCLYLNIYSPADLTKSSLLPVMVWIHGGGLMTGGAS 150

  Fly   145 REWYGPDYFMKEDVVLVTIQYRLGALGFMSLKSPELNVPGNAGLKDQVLALKWIKNNCASFGGDP 209
            . :.|......|:||:||||||||..|..|  :.:.:..||....||:.||:|:::|.|:|||:|
Mouse   151 L-YNGLALSAHENVVVVTIQYRLGIWGLFS--TGDEHSRGNWAHLDQLAALRWVQDNIANFGGNP 212

  Fly   210 NCITVFGESAGGASTHYMMLTDQTQGLFHRGILQSGSAICPWAYNGDITHNPYRIAKLVGYKGED 274
            :.:||||.||||.|...::|:...:.||||.|.:|...:.......|:.  ...:::::......
Mouse   213 DSVTVFGSSAGGVSVSVLVLSPLAKNLFHRAISESSVVLENIVITLDLV--ACDLSQMIATVSGC 275

  Fly   275 NDKDVLEFLQNVKAKDLIRVEENVL---TLEERMNKIMFAFGPSLEPFSTPE----CVISKPPKE 332
            ||......:|.::.|     .||.|   |::..:.|:..|.....:..|...    .|:.|.|:|
Mouse   276 NDTSSTAMVQCLRQK-----TENELLEITVKLEVTKVGGAASAKKDNTSMSTVIDGVVLPKAPEE 335

  Fly   333 MMKTAWSNSIPMFIGNTSYEGLLWVPEV------------------------------KLMPQVL 367
            ::.....:::|..:|....|....:|.:                              .|:|.|:
Mouse   336 ILAEKSFSTVPYIVGFNKQEFGWIIPTMLGDLLSEGKMNEETASLLLRRFHSDLNISESLIPAVI 400

  Fly   368 QQLDAGTPFIPKELLATEPSKEKLDSWSAQIRDVHRTGSESTPDNYMDLCSIYYFVFPALRVVHS 432
            ::...||         .:|:|::                    |..:|:.|..:|..||  |:.|
Mouse   401 EKYLRGT---------DDPAKKR--------------------DLLLDMFSDVFFGIPA--VLLS 434

  Fly   433 RHAYAAGAPVYFYRYDFDSEELIFPYRIM----RLGRGVKGVSHADDLSYQFSSLLARRLPKE-- 491
            |....||...|.|.         |.||..    :..:.|:| .|.|::    .|:....|.||
Mouse   435 RSLRDAGVSTYMYE---------FRYRPSFVSDKRPQTVEG-DHGDEI----FSVFGIPLLKEGT 485

  Fly   492 SREYRNIERTV-GIWTQFAATGNPYSEKINGMDTLTIDPVRKSDEVIKCLNISDDLKFIDLPEWP 555
            |.|..|:.:.| ..|..||..|||..|                                .||.||
Mouse   486 SEEETNLSKMVMKFWANFARNGNPNGE--------------------------------GLPHWP 518

  Fly   556 KLKVWESLYDDNKDLL 571
            :       ||:.:..|
Mouse   519 E-------YDEKEGYL 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est7	NP_524261.1	COesterase	27..514	CDD:278561	156/542 (29%)
alpha-Est7	NP_524261.1	Aes	<116..>221	CDD:223730	46/105 (44%)
Ces1b	NP_001074841.1	COesterase	19..547	CDD:278561	166/601 (28%)
Ces1b	NP_001074841.1	Aes	<121..>239	CDD:223730	50/120 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832604
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.650