DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est7 and gas

DIOPT Version :9

Sequence 1:	NP_524261.1	Gene:	alpha-Est7 / 40901	FlyBaseID:	FBgn0015575	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_611678.1	Gene:	gas / 37572	FlyBaseID:	FBgn0034736	Length:	566	Species:	Drosophila melanogaster

Alignment Length:	573	Identity:	274/573 - (47%)
Similarity:	366/573 - (63%)	Gaps:	22/573 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNKNLGFVERLRWRLKTIEHKVQQYRQSTNETVVADTEYGQVRGIKRLSLYD-VPYFSFEGIPYA 64
            |:..:.|.::|:...|.|.|||.||:..|.:|....|:|||::|.:|.:||| .||:||||||:|
  Fly     1 MDLRVSFSDKLKLGAKIIGHKVVQYKLGTGQTKELATKYGQLKGQQRRTLYDGEPYYSFEGIPFA 65

  Fly    65 QPPVGELRFKAPQRPIPWERVRDCSQPKDKAVQVQFVFDKVEGSEDCLYLNVYTNNVKPDKARPV 129
            |||||||||:|||.|..|:.||||:..::|.:|...:.:..||||||||||||...::..|..||
  Fly    66 QPPVGELRFRAPQPPSSWQGVRDCTYAREKPMQRNSITNAAEGSEDCLYLNVYAKRLESPKPLPV 130

  Fly   130 MVWIHGGGFIIGEANREWYGPDYFMKEDVVLVTIQYRLGALGFMSLKSPELNVPGNAGLKDQVLA 194
            ||||.||||.:|.|:||.||||||||.|::||||.||:|.|||:|||..||.:|||||||||:.|
  Fly   131 MVWIFGGGFQVGGASRELYGPDYFMKHDILLVTINYRVGVLGFLSLKDKELKIPGNAGLKDQIQA 195

  Fly   195 LKWIKNNCASFGGDPNCITVFGESAGGASTHYMMLTDQTQGLFHRGILQSGSAICPWAYNGDITH 259
            |:|:|.|.|||.|||..||||||||||||||.:|.|:|.:|||||.|:|||||:|.||...| ..
  Fly   196 LRWVKENIASFNGDPESITVFGESAGGASTHILMQTEQARGLFHRAIVQSGSALCAWATQPD-RK 259

  Fly   260 NPYRIAKLVGYKGE-DNDKDVLEFLQNVKAKDLIRVEENVLTLEERMNKIMFAFGPSLEPFSTPE 323
            .|.|:.|.:||.|. :::|::|||.|.:.|..|.:...:::|.||:.:..:.||.|.:||:...:
  Fly   260 WPQRLGKELGYAGNLESEKELLEFFQQIPASKLAQYCNSIVTQEEQRDYEILAFAPVIEPYVGDD 324

  Fly   324 CVISKPPKEMMKTAWSNSIPMFIGNTSYEGLLWVPEVKLMPQVLQQLDAGTPFIPKELLATEPSK 388
            |||.|..:|.:.:||.|||||.||.||:|||......  :...|..|.|....|||: :.....|
  Fly   325 CVIPKSQQEQLSSAWGNSIPMIIGGTSFEGLFSYRTT--LDDPLYMLSAFEAIIPKQ-VRDAIDK 386

  Fly   389 EKLDSWSAQIRDVHRTGSESTPD-------NYMDLCSIYYFVFPALRVVHSRHAYAAGAPVYFYR 446
            |:|   :..:|.:.::..:. ||       ..:.:.||..|.....|.:.:|.|||...|.|.||
  Fly   387 EEL---AEMVRRLKKSYFDD-PDRASMELYECLHILSIKNFWHDIHRTLLARLAYATNLPTYLYR 447

  Fly   447 YDFDSEELIFPYRIMRLGRGVKGVSHADDLSYQFSSLLARRLPKESREYRNIERTVGIWTQFAAT 511
            :|.||..... |||::.|:.|:||.||||:||.|..:|:.:|.|.|.|||.|||.||:||.||.|
  Fly   448 FDMDSPHFNH-YRILKCGKKVRGVCHADDISYMFYGILSSKLDKNSPEYRTIERLVGMWTSFATT 511

  Fly   512 GNPYSEKINGMDTLTIDPVRKSDEVIKCLNISDDLKFIDLPEWPKLKVWESLY 564
            |:|..|.|   ..:..||:|... |..||||:|.|:||.|||..:..||:|.|
  Fly   512 GDPNCEII---APVKWDPLRPGG-VENCLNIADGLEFIPLPESKQFVVWDSFY 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est7	NP_524261.1	COesterase	27..514	CDD:278561	242/495 (49%)
alpha-Est7	NP_524261.1	Aes	<116..>221	CDD:223730	69/104 (66%)
gas	NP_611678.1	COesterase	28..534	CDD:278561	249/518 (48%)
gas	NP_611678.1	Aes	<117..>222	CDD:223730	69/104 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467345
Domainoid	1	1.000	450	1.000	Domainoid score	I1603
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	492	1.000	Inparanoid score	I3113
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG26273
OrthoDB	1	1.010	-	-		D18817at7147
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	1	1.100	-	-	P	PTHR43142
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	12	11.810