DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est7 and Jhedup

DIOPT Version :9

Sequence 1:	NP_524261.1	Gene:	alpha-Est7 / 40901	FlyBaseID:	FBgn0015575	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_611085.2	Gene:	Jhedup / 36779	FlyBaseID:	FBgn0034076	Length:	559	Species:	Drosophila melanogaster

Alignment Length:	564	Identity:	169/564 - (29%)
Similarity:	249/564 - (44%)	Gaps:	103/564 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 EYGQVRGIKRLSLYDVPYFSFEGIPYAQPPVGELRFKAPQRPIPWERVRDCSQPKDKAVQVQFVF 102
            :.|.:||..........:.:|.|||:||||||.||.|.|....|||.|.|....||..:|..: |
  Fly    26 DMGCMRGTLMPGYQSGEFEAFMGIPFAQPPVGPLRLKNPVPNEPWEGVLDAGAAKDSCIQRSY-F 89

  Fly   103 DK---VEGSEDCLYLNVYTNNVKPDKARPVMVWIHGGGFIIGEANREWYGPDYFMKED-VVLVTI 163
            .|   :.|.|||||||||....:.:...||||:||||||..|.|:....||:|.|..: ||:||:
  Fly    90 AKEWGLMGVEDCLYLNVYRPKNRAEDKLPVMVYIHGGGFFSGSAHPMASGPEYLMDTNKVVMVTM 154

  Fly   164 QYRLGALGFMSLKSPELNVPGNAGLKDQVLALKWIKNNCASFGGDPNCITVFGESAGGASTHYMM 228
            .||||..||:|  :.:.::|||.|.|||.|||:||:.:.|:|||||..:||.|.||||.|.|..|
  Fly   155 NYRLGPFGFLS--TGDEHMPGNFGFKDQRLALQWIQKHIATFGGDPKKVTVLGHSAGGISAHLHM 217

  Fly   229 LTDQTQGLFHRGILQSG----SAICPWAYNGDITHNPYRIAKLVGY-----KGED-NDKDVLEFL 283
            ::..::|||...:..:|    ||:       .|..:|...|:.:|.     :.|. :.:|:.|.|
  Fly   218 ISPNSKGLFQNSMSLTGTMFLSAM-------KILKDPLSQARRLGKELAIDQAESLSSQDLAEAL 275

  Fly   284 QNVKAKDLIRVEENVLTLEERMNKIMFAFGPSLEPFSTPECVISKPPKEMMKTAWSNSIPMFIGN 348
            :||..|.|: |..:.|.:.:.|..:...  |.||. .:|:..:.:.|.:..:....|.:|..:..
  Fly   276 RNVCPKKLL-VSVDSLKVWDNMPHLTTL--PVLEA-PSPDAFLVEDPLDAHRAGRINQMPWILSL 336

  Fly   349 TSY--EGLLWVPEVKLMPQ--------------VLQQLDAGTPFIPKELLATEPSKEKLDSWSAQ 397
            :|.  ||.|::....:.|:              :|..|..|||        .:...|.||::..:
  Fly   337 SSRAGEGSLFIMRAFINPKLRAEFNENFLEHMALLLNLPEGTP--------VQMVSEILDAYDFK 393

  Fly   398 IRDVHRTGSESTPDNYMDLCSI---YYFVFPALRVVHSRHAYA--AGAPVYFYRYDFDSEELIFP 457
                   |.....|..:.|..|   :.|.:|....:.|...||  ...|::.|.::|.....|..
  Fly   394 -------GDSLNNDTMLKLAEISGDFNFYYPIYETISSYVTYANLEENPLFIYIFEFAGLNSITK 451

  Fly   458 YRIMRLGRGVKGVSHADD------LSYQFSSLLARRLPKESREYRNIERTVGIWTQFAATG---- 512
            :..........|..|.||      :...|..     .||:|.:.:.|:|...:.|.||.||
  Fly   452 FFAGTTDDYGLGAVHMDDGLHTIRIPVSFDD-----FPKDSEDAKVIQRMSSLMTDFAKTGVFHE 511

  Fly   513 ------------------------NPYSEKINGMDTLTIDPVRK 532
                                    ..|.|.|....|||..|:.|
  Fly   512 ESICKVSDFKEQGMCNYLHFGGNKEKYLEDIRNSITLTAFPIWK 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est7	NP_524261.1	COesterase	27..514	CDD:278561	161/544 (30%)
alpha-Est7	NP_524261.1	Aes	<116..>221	CDD:223730	52/105 (50%)
Jhedup	NP_611085.2	COesterase	31..508	CDD:278561	159/510 (31%)
Jhedup	NP_611085.2	Aes	<106..>210	CDD:223730	52/105 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440395
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	9	8.800