DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est7 and CG4382

DIOPT Version :9

Sequence 1:	NP_524261.1	Gene:	alpha-Est7 / 40901	FlyBaseID:	FBgn0015575	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_609301.2	Gene:	CG4382 / 34279	FlyBaseID:	FBgn0032132	Length:	580	Species:	Drosophila melanogaster

Alignment Length:	567	Identity:	157/567 - (27%)
Similarity:	257/567 - (45%)	Gaps:	70/567 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 VVADTEYGQVRGIKRLSLYDVPYFSFEGIPYAQPPVGELRFKAPQRPIPWERVRDCSQPKDKAVQ 97
            :|..|..|::||....|.....:::|.|||||:|||..|||:.|:....|....|.:....|..|
  Fly    44 LVITTALGKIRGTILPSQSGRNFYAFRGIPYAKPPVDRLRFQPPEPVEQWFDTLDATFDGPKCPQ 108

  Fly    98 VQFVFDKVEGSEDCLYLNVYTNNV----KPDKARPVMVWIHGGGFI-IGEANREWYGPDYFMKED 157
            :..|...|  |||||.:|:||..:    :|:..|||:|:||.|||. :...::.:.||.|||...
  Fly   109 LGLVSGDV--SEDCLRVNIYTKELPSESQPNVRRPVIVFIHPGGFYSLSGQSKNFAGPQYFMNRR 171

  Fly   158 VVLVTIQYRLGALGFMSLKSPELNVPGNAGLKDQVLALKWIKNNCASFGGDPNCITVFGESAGGA 222
            :||||..||||:|||::..:.|  .|||.||||||..|:|:|.:.:.|||||:.||:.|..||..
  Fly   172 LVLVTFNYRLGSLGFLATGTRE--APGNMGLKDQVQLLRWVKLHISRFGGDPSSITLLGYGAGAM 234

  Fly   223 STHYMMLTDQTQGLFHRGILQSGSAICPWA---YNGDITHNPYRIAKLVGYKGEDNDKDVLEFLQ 284
            :....|::..::||||:.|:.||:....|:   :..|:......:...       :.::|.|.:.
  Fly   235 AVTLHMVSPMSRGLFHKAIVMSGAVTGQWSLPDHQMDVATKQATLLHC-------HTENVTEMMD 292

  Fly   285 NVKAKDLIRVEENVLTL-EERMNKIMFAFGPSLEP-FSTPECVISKPPK-----EMMKTAWSNSI 342
            .:|.|..:.....:..: |...|..:..:.|.:|| |.....::.:|.:     :.||      :
  Fly   293 CLKGKHYLEFANTLPKMFEFDRNNPLILWKPVIEPDFGQERFLVEEPIRSYQNDDFMK------V 351

  Fly   343 PMFIGNTSYEGLLWVPEVKLMPQVLQQLDAGTPFIPKELLATEPSKEKLDSWSAQIRDVHRTGSE 407
            |:..|.|..|.:.....:...|.:|..|:.....:.........|..:..:.|.::|:.:
  Fly   352 PIITGMTKDEFVGPALSILQSPTLLSALNENFESLAPVFFMYNTSDARACNISQELRNHY----- 411

  Fly   408 STPDNYMD-------LCSIYYFVFPALRVVHSRHAYAAGAPVYFYRYDFD-SEELIF-----PYR 459
             .||..:|       |.::|........:....|..|....||:||:.:. :...|:     ||
  Fly   412 -FPDKLIDANRSLEALSNLYSDALTGFGIHRFVHLAARSTKVYYYRFSYQGARSHIYYPEDAPY- 474

  Fly   460 IMRLGRGVKGVSHADDLSYQF-SSLLARRLPKESREYRNIERTVGIWTQFAATGNPYSEKINGMD 523
                     ||.|.|||.|.| ...::|...::..|:|.::..|.:::.||..|:|     |...
  Fly   475 ---------GVVHHDDLMYLFVEPSISRMFTEDDDEFRMVDIMVRMFSAFAYKGDP-----NKPT 525

  Fly   524 TLTIDPVRKSDEVIKCLNISDDLKFIDLPE---WPKLKVWESLYDDN 567
            .|.:..:|......|.....|..|.|.|.|   ....::|:.|:..|
  Fly   526 DLALRDIRWRPFSFKKRYYLDIGKHITLEENLNAENYEIWKRLFPLN 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est7	NP_524261.1	COesterase	27..514	CDD:278561	144/509 (28%)
alpha-Est7	NP_524261.1	Aes	<116..>221	CDD:223730	50/109 (46%)
CG4382	NP_609301.2	COesterase	41..565	CDD:278561	154/558 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467406
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	9	8.800