DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est7 and CG3841

DIOPT Version :9

Sequence 1:	NP_524261.1	Gene:	alpha-Est7 / 40901	FlyBaseID:	FBgn0015575	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_001188759.1	Gene:	CG3841 / 34278	FlyBaseID:	FBgn0032131	Length:	564	Species:	Drosophila melanogaster

Alignment Length:	564	Identity:	166/564 - (29%)
Similarity:	254/564 - (45%)	Gaps:	94/564 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 VADTEYGQVRGIKRLSLYDVPYFSFEGIPYAQPPVGELRFKAPQRPIPW-----ERVRD---CSQ 90
            |.:...|:::|....|..:...::|.||.|||.|||:|||..|.....|     ....|   |.|
  Fly    30 VVELSLGRIQGDTMQSFGNKTIYAFRGIRYAQSPVGQLRFANPVPETSWGDEVFNATSDSLVCPQ 94

  Fly    91 PKDKAVQVQFVFDKVEGSEDCLYLNVYTNNVKPDKARPVMVWIHGGGFIIGEANREW-YGPDYFM 154
            |...::.          |||||.:||:|.:.: ||. ||||:||||..::|..:..: .||.|.:
  Fly    95 PGVVSLM----------SEDCLKINVFTKSFE-DKF-PVMVYIHGGANVLGSGHSSYEAGPQYLL 147

  Fly   155 KEDVVLVTIQYRLGALGFMSLKSPELNVPGNAGLKDQVLALKWIKNNCASFGGDPNCITVFGESA 219
            .:|||.|...||||||||:|..|.|  ..||.|..|||:||:|::::.:.|||||..:|:.|.||
  Fly   148 DQDVVFVAFNYRLGALGFLSTNSSE--TKGNFGFLDQVMALEWVRDHISHFGGDPELVTIIGISA 210

  Fly   220 GGASTHYMMLTDQTQGLFHRGILQSGSAICPWAYNGDITHNPY--RIAKLVGYKGEDNDKDVLEF 282
            |..:....:.:..:.|||||.||.||||    ..:.||.:..:  ::|:.:|....| ..||:|.
  Fly   211 GSMAVSLHLASPLSAGLFHRAILMSGSA----TNHFDIDNLFWTRKLARELGCPMYD-PTDVVEC 270

  Fly   283 LQN---VKAKDLIRVEENVLTLEERMNKIMFAFGPSLEPFSTPECVISKPPKEMMKTAWSNSIPM 344
            |:|   .:..::.:..|....:..:.|            :......:...|.|::|....|.:|:
  Fly   271 LRNETWTRIVEVCKAWETYQLVNMKWN------------YEIDGHFLHNHPTELIKEGNFNKVPL 323

  Fly   345 FIGNTSYEGLLWVPEVKLMPQVLQQLDAGTPFI---PKELLATEPSK--EKLDSWSAQIRDVHRT 404
            .|..|:.| ..:...|.|..|.|.. |..:.|:   |:..|....::  |||       :|.: .
  Fly   324 LISFTANE-FDYNANVHLENQHLLH-DFASNFVDYAPELFLYRHDAQIGEKL-------KDFY-L 378

  Fly   405 GSESTP------DNYMDLCSIYYFVFPALRVVHSRHAYAAGAPVYFYRYDF-DSEELIFPYRIMR 462
            |..:|.      :|:..:.|..|......|:|.....:   .|||:.|.|: ..:.|..|..
  Fly   379 GDNTTEINSENIENFGQIFSDAYIGHGVHRLVQLASHF---TPVYYTRMDYVGDQSLSAPLN--- 437

  Fly   463 LGRGVK-GVSHADDL-----SYQFSSLLARRLPKESREYRNIERTVGIWTQFAATGNPYSEKING 521
             |.... ||.|||||     .|.:..|:|    ....:...:||....:|.||.||.|    :|.
  Fly   438 -GENKPVGVGHADDLHYVLPGYWYGPLMA----ANDSDVFMMERLTSWFTHFAKTGTP----LNS 493

  Fly   522 MDTLTIDPVRKSDEVIKCLNISDDLKFIDLPEWP-KLKVWESLY 564
            .|   |.|...| .|:|.| .:..:..:..|.:. :..||:.|:
  Fly   494 TD---IWPPCNS-TVLKML-YNGVVTQVGSPGYSNRYAVWDKLF 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est7	NP_524261.1	COesterase	27..514	CDD:278561	153/511 (30%)
alpha-Est7	NP_524261.1	Aes	<116..>221	CDD:223730	49/105 (47%)
CG3841	NP_001188759.1	COesterase	27..528	CDD:278561	163/558 (29%)
CG3841	NP_001188759.1	Aes	<116..>235	CDD:223730	55/122 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467405
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43142
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	9	8.890