DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est7 and CG9287

DIOPT Version :9

Sequence 1:	NP_524261.1	Gene:	alpha-Est7 / 40901	FlyBaseID:	FBgn0015575	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_609244.1	Gene:	CG9287 / 34194	FlyBaseID:	FBgn0032057	Length:	625	Species:	Drosophila melanogaster

Alignment Length:	619	Identity:	178/619 - (28%)
Similarity:	257/619 - (41%)	Gaps:	167/619 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VERLRWRL--------KTIEHKV--QQYRQSTNETVVADTEYGQVRG-------IKRLSLYDVPY 55
            ::.|.|::        ..:|.:|  :||.:. .:|:|.....|.::|       .||..|
  Fly     1 MQLLWWQIVSLLLVLQSVVESRVRGRQYDEE-KDTIVELPTLGSIQGKILETAWTKREVL----- 59

  Fly    56 FSFEGIPYAQPPVGELRFKAPQRPI-PWERVRDCSQPKDKAVQVQFV-----FDKVEGSEDCLYL 114
             .|..:.||:||.|..||||| ||| |||.|.|.:..|.....|..:     .|.|...||||.:
  Fly    60 -QFVDVRYAEPPTGLHRFKAP-RPIEPWEDVMDATAEKIGCPSVVSMDSLRRLDDVLDVEDCLTM 122

  Fly   115 NVYTNNVKPDKARPVMVWIHGGGFIIGEANREWYGPDYFMKEDVVLVTIQYRLGALGFMSLKSPE 179
            .:.|.||  ....||:|:|| |.::...:|.| ..|||.:::||||||.|||||..||:|.|:.|
  Fly   123 TITTPNV--TSRLPVLVYIH-GEYLYEGSNSE-APPDYLLEKDVVLVTPQYRLGPFGFLSTKTDE 183

  Fly   180 LNVPGNAGLKDQVLALKWIKNNCASFGGDPNCITVFGESAGGASTHYMMLTDQTQ-GLFHRGILQ 243
              :|||||..|..|||:::|:....|||||:.:||.|:..|.|..|.:.|:...| ||||:.|..
  Fly   184 --IPGNAGFLDIFLALQFVKHFIKYFGGDPSRVTVAGQVGGAAIAHLLTLSPVVQRGLFHQVIYH 246

  Fly   244 SGSAICPWAYNGDITHNPYRIAKLVGYKGEDNDKDVLEFLQNVKAKDLIRVEENVLTLEERMNK- 307
            |||||.|.....|...:...|||....| ....:|:...|..:.|.:|:     ...:|..:.|
  Fly   247 SGSAIMPIFLEEDPRKHAQEIAKKADCK-MVTVRDLNTCLMELTALELL-----TAFMEHALEKS 305

  Fly   308 ---------IMFAFGPSLEPFSTPECVISKPPKEMM--------------KTAWSNSIPMFIGNT 349
                     |.|..|       .|..|:.|.|.::|              |.|.|..:...:.|
  Fly   306 DLGIGHTGGIQFTIG-------GPSGVLPKHPYDLMLETNFSYPAMGGCPKNAGSRVLNEIVDN- 362

  Fly   350 SYEGLLWVPE-----VKLMPQVLQQLDAGTPFIPKELLATE-----------PSKEKLDSWSAQI 398
            .:||.  :|:     ...:..|::| ..||   .|.:|.|.           ......|:...::
  Fly   363 DFEGK--IPDDEYNTYNYIDHVIRQ-TVGT---DKTMLLTSFVTHDFFNRNLMENGTFDTLIPRL 421

  Fly   399 RDVHRT-------------GSESTPDNYMDLCSIYYFVFPALRVVHSRHAYAAGAPVYFYRY-DF 449
            .||..|             .::..|||..    :|.|.:             ||.   |.|| :.
  Fly   422 IDVAGTLNHKLPVLLALNMNNKHNPDNTF----LYSFDY-------------AGE---FNRYKEM 466

  Fly   450 DSE-ELIFPYRIMRLGRGVKGVSHADDLSYQFS-----SLLARRLPKESREYRNIERTVGIWTQF 508
            |.| .|..|::        .|||..|:..|.|.     :.|:|  |.:|..:|.:|    :||.|
  Fly   467 DEETNLQSPFK--------AGVSLTDEALYLFPYPEHVTRLSR--PDQSMAHRMVE----LWTNF 517

  Fly   509 AATGNP---------------YSEKINGMDTLTI 527
            ..:|||               |...:...||:||
  Fly   518 VISGNPLGSARVGYWPPMTTLYGPYMRIDDTMTI 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est7	NP_524261.1	COesterase	27..514	CDD:278561	165/560 (29%)
alpha-Est7	NP_524261.1	Aes	<116..>221	CDD:223730	48/104 (46%)
CG9287	NP_609244.1	COesterase	31..558	CDD:278561	172/589 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467460
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43142
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.900