DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est7 and Ces5a

DIOPT Version :9

Sequence 1:	NP_524261.1	Gene:	alpha-Est7 / 40901	FlyBaseID:	FBgn0015575	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_001012056.2	Gene:	Ces5a / 307660	RGDID:	1549717	Length:	575	Species:	Rattus norvegicus

Alignment Length:	600	Identity:	172/600 - (28%)
Similarity:	249/600 - (41%)	Gaps:	158/600 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 RQSTNETVVADTEYGQVRG-----IKRLSLYDVPYFSFEGIPYAQPPVGELRFKAPQRPIPWERV 85
            |.|..|.....|..|.|:|     :.||.    |...|.|||:|.||:|.|||..||.||||..:
  Rat    24 RGSVTEEPHRYTRLGWVQGKQATVLGRLE----PVNVFLGIPFAAPPLGPLRFSNPQPPIPWHDL 84

  Fly    86 RDCSQPKDKAVQ-VQFVF----------DKVEGSEDCLYLNVYTNNVKPDKAR-PVMVWIHGGGF 138
            |:.:...:...| ::::|          .|:..||||||||:|......|.:| |||:||.||||
  Rat    85 REATTYPNVCFQNLEWLFIYQNLLKVHYPKLGVSEDCLYLNIYAPAYANDGSRLPVMMWIPGGGF 149

  Fly   139 IIGEANREWYGPDYFMKEDVVLVTIQYRLGALGFMSLKSPELNVPGNAGLKDQVLALKWIKNNCA 203
            ..|.|: .:.|......|||::||||||||..||.:.::.  :.|||...:||:.||:|::.|..
  Rat   150 ETGSAS-IFDGSALAAYEDVLIVTIQYRLGIFGFFNTQNQ--HAPGNWAFQDQLAALQWVRENIN 211

  Fly   204 SFGGDPNCITVFGESAGGASTHYMMLTDQTQGLFHRGILQSGSAICPWAYNGD--ITHNPYRIAK 266
            .|||:|:.:|:||.|||..|...::|:..:.|||||.|:|||.||.|...|.|  :.|....:|.
  Rat   212 YFGGNPDSVTIFGGSAGAISISSLILSPLSAGLFHRAIMQSGVAIIPSLKNFDDELKHGLQVVAD 276

  Fly   267 LVGYKGEDN--------DKDVLEFLQ-NVKAKDLIRVEENVLTLEERMNKI---MFAFGPSLEPF 319
            :......|:        :|..||.|. ..|.|...||.:.....||.|..:   .|...||:...
  Rat   277 VCKCNVSDSKVLLKCLREKSSLELLSLGQKTKAFTRVVDGSFFPEEPMELLSQKTFKTVPSIIGV 341

  Fly   320 STPECVISKPPKEMMKTAWSNSIPMFIGNTSYEGLLWVPEVKLMPQVLQQLDAGTPFIPKELLAT 384
            :..||....|.:|..:..:.::....:  |....||.:|     ||.:.       .:.|:....
  Rat   342 NNQECGYILPMREAPEILFGSNESTAL--TLIHVLLHIP-----PQYMH-------IVAKDYFHG 392

  Fly   385 EPSKEKLDSWSAQIRDVHRTGSESTPDNYMDLCSIYYFVFPALRVVHSRHAYAAGAPVYFYRYD- 448
            :.|          :.|:.        |..:||....:||.|.|  |.:|:...||.|||||.:.
  Rat   393 KHS----------LTDIR--------DTLLDLFGDVFFVVPGL--VTARNHRDAGGPVYFYEFQH 437

  Fly   449 ----FDSEELIFPYRIMRLGRGVKGVSHADDLSYQF------------------SSLLARRLPKE 491
                |.:....|          || ..|.|::.:.|                  ..||:|::
  Rat   438 RPNCFQNTRPAF----------VK-ADHTDEIRFVFGGPFLEGDVVMFEEATEDEKLLSRKM--- 488

  Fly   492 SREYRNIERTVGIWTQFAATGNPYSEKINGMDTLTIDPVRKSDEVIKCLNISDDLKFIDLPEWPK 556
                      :..|..||.:|:|..:                                |||.||
  Rat   489 ----------MSYWANFARSGDPNGD--------------------------------DLPLWP- 510

  Fly   557 LKVWESLYDDNKDLL 571
                  .||.|:..|
  Rat   511 ------AYDQNESYL 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est7	NP_524261.1	COesterase	27..514	CDD:278561	161/540 (30%)
alpha-Est7	NP_524261.1	Aes	<116..>221	CDD:223730	46/105 (44%)
Ces5a	NP_001012056.2	Esterase_lipase	40..529	CDD:238191	166/583 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336116
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.640