DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est7 and Ces4a

DIOPT Version :9

Sequence 1:	NP_524261.1	Gene:	alpha-Est7 / 40901	FlyBaseID:	FBgn0015575	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_001099646.1	Gene:	Ces4a / 291955	RGDID:	1307418	Length:	563	Species:	Rattus norvegicus

Alignment Length:	565	Identity:	157/565 - (27%)
Similarity:	256/565 - (45%)	Gaps:	121/565 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 TEYGQVRGIKRLSLYDVPYFSFEGIPYAQPPVGELRFKAPQRPIPWERVRD-------CSQPKDK 94
            |::|.::| |::.:.|.|...|.|:|::|||||..||..|:.|:||..:||       |.|....
  Rat    38 TKHGILQG-KQVHVGDTPIRVFLGVPFSQPPVGTRRFAPPEPPLPWNGIRDATTYPPSCLQESWG 101

  Fly    95 AVQVQFV-----FDKVEGSEDCLYLNVYTNNVKP-DKARPVMVWIHGGGFIIGEANREWYGPDYF 153
            .:...::     ::.:..||||||||||...:.| |...|||||..||.|::|.|: .:.|.:..
  Rat   102 QITSMYLNTRKQYEWLHFSEDCLYLNVYAPVLAPGDPLLPVMVWFPGGAFLVGSAS-TYEGSELA 165

  Fly   154 MKEDVVLVTIQYRLGALGFMSLKSPELNVPGNAGLKDQVLALKWIKNNCASFGGDPNCITVFGES 218
            .:..||||.:|||||.|||.|  :...:..||.||.||:.||:|::.|..:|||||:.:|:||:|
  Rat   166 ARGKVVLVFLQYRLGILGFFS--TGNSHARGNWGLLDQIAALRWVQENIEAFGGDPDSVTLFGQS 228

  Fly   219 AGGASTHYMMLTDQTQGLFHRGILQSGSAICPWAYNGDITHNPYRIAKLVGY-KGEDND--KDVL 280
            ||..|...::::...|||||:.|.|||:|:    ....|||:|.:.||.:.: .|.|::  |.::
  Rat   229 AGAMSVSGLLMSPLAQGLFHQAISQSGTAV----LKTFITHDPLKSAKKIAHLAGCDHNSTKIMV 289

  Fly   281 EFLQNVKAKDLIRVEENVLTLEERMNK----IMFAFGPSLEPFSTPECVISKPPKEMMKTAWSNS 341
            :.|:.:.|:.::.|.:.:.......:|    |::...|.::....||     .|..::.......
  Rat   290 KCLKALPAEKVMLVSKKMTFFRANSHKDPKDIVWFLSPVVDGLVFPE-----DPVVLLTRGQVKP 349

  Fly   342 IPMFIGNTSYE------------------------GLLWVPEVKLMPQVLQQLDAGTPFIPKELL 382
            :|..:|..|.|                        .|||...:     :|...:...|.:.:|.|
  Rat   350 VPYLLGVNSAEFEWSLPFLMKLQLNQRIMNKNYITKLLWSCSI-----LLNITEEQIPLVAREYL 409

  Fly   383 ATEPSKEKLDSWSAQIRDVHRTGSESTPDNYMDLCSIYYFVFPALRVVHSRHAYAAGAPVYFYRY 447
            :...|..   .|            :...::.:||.....||:..|:.  :|:...||:|||.|.:
  Rat   410 SDAISHH---DW------------KMFRNHLIDLVGDATFVYATLQA--ARYHRDAGSPVYLYEF 457

  Fly   448 DFDSEELIFPYRIMRLGRGVKGVSHADDLSYQFSSLLARRLPK-ESREYRNIERTVGIWTQFAAT 511
            ...:..:|...|       ..|..|.|:|||.|.|..::...: |.:|:.  .:.:..|..||.|
  Rat   458 KHHAPGIIVKPR-------SDGADHGDELSYLFGSPFSKGSSRGEEKEFS--LQMMKYWANFAHT 513

  Fly   512 GNPYSEKINGMDTLTIDPVRKSDEVIKCLNISDDLKFIDLPEWPK 556
            |:|...                                :||.||:
  Rat   514 GDPNDR--------------------------------ELPYWPR 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est7	NP_524261.1	COesterase	27..514	CDD:278561	152/521 (29%)
alpha-Est7	NP_524261.1	Aes	<116..>221	CDD:223730	48/105 (46%)
Ces4a	NP_001099646.1	COesterase	33..554	CDD:395084	157/565 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336423
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.650