DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est7 and Ces2g

DIOPT Version :9

Sequence 1:	NP_524261.1	Gene:	alpha-Est7 / 40901	FlyBaseID:	FBgn0015575	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_001099645.1	Gene:	Ces2g / 291952	RGDID:	1308358	Length:	560	Species:	Rattus norvegicus

Alignment Length:	588	Identity:	178/588 - (30%)
Similarity:	265/588 - (45%)	Gaps:	124/588 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 QYRQSTNETVVADTEYGQVRG-IKRLSLYDVPYFSFEGIPYAQPPVGELRFKAPQRPIPWERVRD 87
            |.:.|...:.:.:|..|||:| :.....:.....:|.|||:|:.|||.|||..|:.|.||..|||
  Rat    25 QGQHSPESSPIRNTHTGQVQGKLTHSKDFKSGVHTFLGIPFAKAPVGPLRFAPPEAPEPWSGVRD 89

  Fly    88 -------CSQ----PKDKAVQVQFVFDKVEGSEDCLYLNVYTNNVKPDKAR-----PVMVWIHGG 136
                   |.|    ..:...:::.....|..||||||||:|.    |..|.     |||||||||
  Rat    90 GTSQSNICPQNVRMNMEGLKEMKLTLPPVSMSEDCLYLNIYA----PAHAHEGSHLPVMVWIHGG 150

  Fly   137 GFIIGEANREWYGPDYFMKEDVVLVTIQYRLGALGFMSLKSPELNVPGNAGLKDQVLALKWIKNN 201
            ...:|.|:. :.|......||||:||||||||.|||.|  :.:.:..||.|..|||.||:|::.|
  Rat   151 ALTVGMASM-YDGSMLAATEDVVVVTIQYRLGVLGFFS--TGDHHARGNWGYLDQVAALRWVQQN 212

  Fly   202 CASFGGDPNCITVFGESAGGASTHYMMLTDQTQGLFHRGILQSGSAICPWA-YNGDITHNPYR-I 264
            .|.|||:|:|:|:|||||||.|....:::..::|||||.|::||.|:.|.. :|  .:...|: :
  Rat   213 IAHFGGNPDCVTIFGESAGGLSVSSHVVSPMSKGLFHRAIMESGVALMPGTIFN--FSEMVYQMV 275

  Fly   265 AKLVGYKGEDNDKDVLEFLQNVKAKDLIRVEENVLTLEERMNKIMFAFGPSLEPFSTPECV---- 325
            .||.|.:..|.:    ..:..::.|.    ||.:..:.:....|             |..|
  Rat   276 VKLSGCEAMDPE----SLVHCLRGKS----EEQITVISKEFQMI-------------PAVVDGEF 319

  Fly   326 ISKPPKEMMKTAWSNSIPMFIG--NTSYEGLLW-VPEVKLMPQVL-----QQLDAGTPFI----P 378
            :...|:|::.:|..:.:|..||  |..|.   | ||:|....|.:     :.|.|   |:    |
  Rat   320 LPNHPQELLASADFHPVPSIIGFNNDEYG---WIVPKVIGSAQTIKGITRENLQA---FLKDTAP 378

  Fly   379 KELLATEPSKEKLDSWSAQIRDVHRTGSESTPDNYMDLCSIYYFVFPALRVVHSRHAYAAGAPVY 443
            :.:|..|.|...::.:...|.|     .::....:.::...:.||.|:|:|...:.::   ||||
  Rat   379 QMMLPPECSDLLMEEYMGDIED-----PQTLQAQFTEMMEDFMFVIPSLQVARFQRSH---APVY 435

  Fly   444 FYRYDFDSEEL--IFPYRIMRLGRGVKGVSHADDLSYQFSS--------------LLARRLPKES 492
            ||.:...|..|  |.|..:.        ..|.|::.:.|.|              ||.||:.|
  Rat   436 FYEFQHQSSFLKDIRPPHVK--------ADHGDEVPFVFGSFFWGMKLNLTEGEKLLNRRMMK-- 490

  Fly   493 REYRNIERTVGIWTQFAATGNPYSEKINGMDTLTIDPVRKSDEVIKCLNISDDLKFIDLPEWPKL 557
                       .|..||..|||.|      ::|...||...||....||....:..|....  ||
  Rat   491 -----------YWANFARYGNPNS------NSLPYWPVFDYDEQYLQLNTQPAVGRIQKAR--KL 536

  Fly   558 KVW 560
            :.|
  Rat   537 QFW 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est7	NP_524261.1	COesterase	27..514	CDD:278561	163/537 (30%)
alpha-Est7	NP_524261.1	Aes	<116..>221	CDD:223730	53/109 (49%)
Ces2g	NP_001099645.1	COesterase	31..539	CDD:278561	175/580 (30%)
Ces2g	NP_001099645.1	Aes	<129..>232	CDD:223730	53/109 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336289
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.640