Protein Alignment alpha-Est7 and CES4A

DIOPT Version :9

• Sequence 1: NP_524261.1
• Gene: alpha-Est7 / 40901
• FlyBaseID: FBgn0015575
• Length: 572
• Species: Drosophila melanogaster
• Sequence 2: XP_011521323.1
• Gene: CES4A / 283848
• HGNCID: 26741
• Length: 628
• Species: Homo sapiens
• Alignment Length: 609
• Identity: 164/609 - (26%)
• Similarity: 265/609 - (43%)
• Gaps: 118/609 - (19%)

  Fly    37 TEYGQVRGIKRLSLYDVPYFSFEGIPYAQPPVGELRFKAPQRPIPWERVRD-------------- 87
            |:||.::| |::.:...|...|.|:|:::||:|.|||..|:.|.||:.:||
Human    54 TKYGTLQG-KQMHVGKTPIQVFLGVPFSRPPLGILRFAPPEPPEPWKGIRDATTYPPGWSLALSP 117

  Fly    88 ---------------------------------CSQPKDKAVQVQFV-----FDKVEGSEDCLYL 114
                                             |.|.....:...:|     :..:..|||||||
Human   118 GWSAVARSRLTATSASRVQASLLPQPLSIWGYRCLQESWGQLASMYVSTRERYKWLRFSEDCLYL 182

  Fly   115 NVYTNNVKP-DKARPVMVWIHGGGFIIGEANREWYGPDYFMKEDVVLVTIQYRLGALGFMSL--K 176
            |||.....| |...|||||..||.||:|.|: .:.|.|...:|.||||.:|:|||..||:..  :
Human   183 NVYAPARAPGDPQLPVMVWFPGGAFIVGAAS-SYEGSDLAAREKVVLVFLQHRLGIFGFLRWRGR 246

  Fly   177 SPELNVPGNAGLKDQVLALKWIKNNCASFGGDPNCITVFGESAGGASTHYMMLTDQTQGLFHRGI 241
            :.:.:..||.||.||:.||:|::.|.|:|||||..:|:||:|||..|...:|::....|||||.|
Human   247 TDDSHARGNWGLLDQMAALRWVQENIAAFGGDPGNVTLFGQSAGAMSISGLMMSPLASGLFHRAI 311

  Fly   242 LQSGSAICPWAYNGDITHNPYRIAKLVGYKGEDNDKD---VLEFLQNVKAKDLIRVEENV----L 299
            .|||:|:    :...||.||.::||.|.:....|...   ::..|:.:....::||...:    |
Human   312 SQSGTAL----FRLFITSNPLKVAKKVAHLAGCNHNSTQILVNCLRALSGTKVMRVSNKMRFLQL 372

  Fly   300 TLEERMNKIMFAFGPSLEPFSTPECVISKPPKEMMKTAWSNSIPMFIGNTSYEGLLWVPEVKLMP 364
            ..:....:|:::..|.::     ..||...|..::.....:|:|..:|..:.|....:|.:...|
Human   373 NFQRDPEEIIWSMSPVVD-----GVVIPDDPLVLLTQGKVSSVPYLLGVNNLEFNWLLPYIMKFP 432

  Fly   365 QVLQQLDAGTPFIPKELLATEP----SKEKLDSWSAQIRD-VHRTGSESTPDNYMDLCSIYYFVF 424
            ...|.:...|  |.|.|.:|..    :||::.....:..| |:....:...:..||:.....||:
Human   433 LNRQAMRKET--ITKMLWSTRTLLNITKEQVPLVVEEYLDNVNEHDWKMLRNRMMDIVQDATFVY 495

  Fly   425 PALRVVHSRHAYAAGAPVYFYRYDFDSEELIFPYRIMRLGRGVKGVSHADDLSYQFSSLLARRLP 489
            ..|:..|  :...||.|||.|.::..:..:|...|       ..|..|.|::.:.|....|..|.
Human   496 ATLQTAH--YHRDAGLPVYLYEFEHHARGIIVKPR-------TDGADHGDEMYFLFGGPFATGLS 551

  Fly   490 KESREYRNIERTVGIWTQFAATGNPYSEKINGMDTLTIDPVRKSDEVIKCL-NISDDLKFIDLP- 552
            ....:..::: .:..|..||.||||                  :|..:.|. ..:.|.|::.|.
Human   552 MGKEKALSLQ-MMKYWANFARTGNP------------------NDGNLPCWPRYNKDEKYLQLDF 597

  Fly   553 --------EWPKLKVWESLYDDNK 568
                    :..|:..|.|||...:
Human   598 TTRVGMKLKEKKMAFWMSLYQSQR 621

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est7	NP_524261.1	COesterase	27..514	CDD:278561	152/543 (28%)
		Aes	<116..>221	CDD:223730	49/107 (46%)
CES4A	XP_011521323.1	COesterase	46..613	CDD:278561	160/599 (27%)
		Aes	<184..>291	CDD:223730	49/107 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142752
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	216	1.000	Inparanoid score	I3612
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.700