DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est7 and Ces1a

DIOPT Version :9

Sequence 1:	NP_524261.1	Gene:	alpha-Est7 / 40901	FlyBaseID:	FBgn0015575	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_001013786.2	Gene:	Ces1a / 244595	MGIID:	3648919	Length:	563	Species:	Mus musculus

Alignment Length:	562	Identity:	171/562 - (30%)
Similarity:	246/562 - (43%)	Gaps:	96/562 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 VADTEYGQVRGIKRLSLYD--VPYFSFEGIPYAQPPVGELRFKAPQRPIPWERVRD-------CS 89
            |.||..|:|.| |.:||..  .|...|.|:|:|:||:|.|||..||....|..|::       ||
Mouse    25 VVDTLQGKVMG-KYISLEGSAQPVAVFLGVPFAKPPLGPLRFAPPQPAETWSSVKNTTSYPPMCS 88

  Fly    90 QPKDKAVQVQFVFDK------VEGSEDCLYLNVYTNNVKPDKAR-PVMVWIHGGGFIIGEANREW 147
            |.......:..||..      :|.||||||||:|:......|.| |||||:||||.:.|.|: .:
Mouse    89 QITGVGPVLSDVFTNQLENVPLEYSEDCLYLNIYSPTDLTSKDRLPVMVWVHGGGLLSGGAS-TF 152

  Fly   148 YGPDYFMKEDVVLVTIQYRLGALGFMSLKSPELNVPGNAGLKDQVLALKWIKNNCASFGGDPNCI 212
            .|......|:||:|.||||||..||:|  :.:.:..||.|..|||.||:|::||.|:|||||:.:
Mouse   153 DGLALSTHENVVIVVIQYRLGIWGFLS--TGDEHSRGNWGHLDQVAALQWVQNNIANFGGDPSSV 215

  Fly   213 TVFGESAGGASTHYMMLTDQTQGLFHRGILQSGSAICPWAYNGDITHNPYRIAKLVGYKGEDNDK 277
            |:|||||||.|...::|:..|:.||.|.|.:||.|:.|..:.........::|...|... ....
Mouse   216 TLFGESAGGESVSVLVLSPLTKNLFQRAISESGVALTPCLFRETTRRAAEQVAIATGCVA-TTSA 279

  Fly   278 DVLEFLQNVKAKDLIRVEENVLTLEERMNKIMFA---FGPSLE--PFST---PECVISKPPKEMM 334
            |::..|:.       :.||.:|....:|.  .||   .|...|  ||.|   ...|:.|.|:|::
Mouse   280 DIVHCLRE-------KTEEELLATTLKMK--FFALDLLGDPRESYPFLTTVIDGVVLPKAPEEIL 335

  Fly   335 KTAWSNSIPMFIGNTSYEGLLWVPEVKLMPQVLQQLD--AGTPFIPKELLATEPSKEKLDSWSAQ 397
            .....|::|..:|....|...::|.:...|....:||  :.|..:.|....|..|||     ...
Mouse   336 AEKSFNTVPYIVGINKQEFGWFIPMMMGYPLSEGKLDQKSATSLLWKSYPLTNISKE-----LTP 395

  Fly   398 IRDVHRTGSESTPDN----YMDLCSIYYFVFPALRVVHSRHAYAAGAPVYFYRYDFDSEELIFPY 458
            :......|....||.    ::|:.....|..|:  |:.:|:...||||.|.|.:.:      .|.
Mouse   396 VATEKYLGGSDCPDKKKDLFLDMMGDVLFAVPS--VIVARYHRDAGAPTYMYEFKY------HPS 452

  Fly   459 RIMRLGRGVKGVSHADDLSYQFSSLLARRLPKE--SREYRNIE-RTVGIWTQFAATGNPYSEKIN 520
            .:..:........|.|::    .|:......||  |.|..|:. ..:..|..||..|||..|
Mouse   453 FVSDMRPKTVIADHGDEV----YSVWGTPFLKEGASEEEINLSTMMMKFWGNFARNGNPNGE--- 510

  Fly   521 GMDTLTIDPVRKSDEVIKCLNISDDLKFIDLPEWPKLKVWES 562
                                         .||.||:....||
Mouse   511 -----------------------------GLPHWPEYGEKES 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est7	NP_524261.1	COesterase	27..514	CDD:278561	162/512 (32%)
alpha-Est7	NP_524261.1	Aes	<116..>221	CDD:223730	51/105 (49%)
Ces1a	NP_001013786.2	Esterase_lipase	25..536	CDD:238191	171/562 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832947
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.650