DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est7 and Ces1c

DIOPT Version :9

Sequence 1:	NP_524261.1	Gene:	alpha-Est7 / 40901	FlyBaseID:	FBgn0015575	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	XP_006255234.2	Gene:	Ces1c / 24346	RGDID:	2571	Length:	551	Species:	Rattus norvegicus

Alignment Length:	585	Identity:	169/585 - (28%)
Similarity:	255/585 - (43%)	Gaps:	144/585 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 VADTEYGQVRGIKRLSL--YDVPYFSFEGIPYAQPPVGELRFKAPQRPIPWERVRD-------CS 89
            |.||..|:|.| |.:||  :..|...|.|:|:|:||:|.|||..|:...||..|::       ||
  Rat    27 VVDTTKGKVLG-KYVSLEGFTQPVAVFLGVPFAKPPLGSLRFAPPEPAEPWSFVKNTTTYPPMCS 90

  Fly    90 QPKDKAVQVQFVFD---------KVEGSEDCLYLNVYT-NNVKPDKARPVMVWIHGGGFIIGEAN 144
            |   ..|..:.:.|         .:|.||||||||:|: .::..:...||||||||||.|||.|:
  Rat    91 Q---DGVVGKLLADMLSTGKENIPLEFSEDCLYLNIYSPADLTKNSRLPVMVWIHGGGLIIGGAS 152

  Fly   145 REWYGPDYFMKEDVVLVTIQYRLGALGFMSLKSPELNVPGNAGLKDQVLALKWIKNNCASFGGDP 209
             .:.|......|:||:||||||||..|..|  :.:.:..||....||:.||:|:::|.|:|||:|
  Rat   153 -PYSGLALSAHENVVVVTIQYRLGIWGLFS--TGDEHSRGNWAHLDQLAALRWVQDNIANFGGNP 214

  Fly   210 NCITVFGESAGGASTHYMMLTDQTQGLFHRGILQSGSAICPWAYNGDITHNPYRIAKLVGYKGED 274
            :.:|:|||||||.|...::|:...:.||||.|.:||..:   ..|.| ..|...:|:::......
  Rat   215 DSVTIFGESAGGVSVSVLVLSPLAKNLFHRAISESGVVL---TTNLD-KKNTQAVAQMIATLSGC 275

  Fly   275 NDKDVLEFLQNVKAKDLIRVEENVLTLEERMNKIMFAFGPSLEPFST--PECVISKPPKEMMKTA 337
            |:......:|.::.|    .|..:|.|..:::.         ...||  ...|:.|.|:|::...
  Rat   276 NNTSSAAMVQCLRQK----TEAELLELTVKLDN---------TSMSTVIDGVVLPKTPEEILTEK 327

  Fly   338 WSNSIPMFIGNTSYEGLLWVPEV------------KLMPQVLQQ----LDAGTPFIP----KELL 382
            ..|::|..:|....|....:|.:            |:...:|::    |:.....||    |.|.
  Rat   328 SFNTVPYIVGFNKQEFGWIIPTMMGNLLSEGRMNEKMASSLLRRFSPNLNISESVIPAIIEKYLR 392

  Fly   383 AT-EPSKEKLDSWSAQIRDVHRTGSESTPDNYMDLCSIYYFVFPALRVVHSRHAYAAGAPVYFYR 446
            .| :|:|:|                    :..:|:.|..:|..||  |:.||....||||.|.|.
  Rat   393 GTDDPAKKK--------------------ELLLDMFSDVFFGIPA--VLMSRSLRDAGAPTYMYE 435

  Fly   447 YDFDSEELIFPYRIMRLG----RGVKGVSHADDLSYQFSSLLARRLPKESREYRNIERTV-GIWT 506
                     |.||...:.    :.|:| .|.|::...|.:...:.  ..|.|..|:.:.| ..|.
  Rat   436 ---------FQYRPSFVSDQRPQTVQG-DHGDEIFSVFGTPFLKE--GASEEETNLSKLVMKFWA 488

  Fly   507 QFAATGNPYSEKINGMDTLTIDPVRKSDEVIKCLNISDDLKFIDLPEWPKLKVWESLYDDNKDLL 571
            .||..|||..|                                .||.||:       ||..:..|
  Rat   489 NFARNGNPNGE--------------------------------GLPHWPE-------YDQKEGYL 514

Fly 572 571
Rat 515 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est7	NP_524261.1	COesterase	27..514	CDD:278561	159/526 (30%)
alpha-Est7	NP_524261.1	Aes	<116..>221	CDD:223730	48/105 (46%)
Ces1c	XP_006255234.2	COesterase	24..534	CDD:395084	169/585 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.720