Protein Alignment alpha-Est7 and CES3

DIOPT Version :9

• Sequence 1: NP_524261.1
• Gene: alpha-Est7 / 40901
• FlyBaseID: FBgn0015575
• Length: 572
• Species: Drosophila melanogaster
• Sequence 2: NP_079198.2
• Gene: CES3 / 23491
• HGNCID: 1865
• Length: 571
• Species: Homo sapiens
• Alignment Length: 577
• Identity: 172/577 - (29%)
• Similarity: 253/577 - (43%)
• Gaps: 128/577 - (22%)

  Fly    36 DTEYGQVR----GIKRLS-LYDVPYFSFEGIPYAQPPVGELRFKAPQRPIPWERVRD-------C 88
            ||..|:||    |:|... |.:|    |.|||:||||:|..||.||....|||.|||       |
Human    37 DTTLGRVRGRQVGVKGTDRLVNV----FLGIPFAQPPLGPDRFSAPHPAQPWEGVRDASTAPPMC 97

  Fly    89 SQPKDKAVQVQFVFDKVEG----SEDCLYLNVYT-NNVKPDKARPVMVWIHGGGFIIGEANREWY 148
            .|..:.....:||.:..:.    |||||.||||: ..|.....||||||:|||..|.|.|. .:.
Human    98 LQDVESMNSSRFVLNGKQQIFSVSEDCLVLNVYSPAEVPAGSGRPVMVWVHGGALITGAAT-SYD 161

  Fly   149 GPDYFMKEDVVLVTIQYRLGALGFMSLKSPELNVPGNAGLKDQVLALKWIKNNCASFGGDPNCIT 213
            |.......|||:||:|||||.|||.|  :.:.:.|||.|..|.|.||:|::.|.|.||||.||:|
Human   162 GSALAAYGDVVVVTVQYRLGVLGFFS--TGDEHAPGNQGFLDVVAALRWVQENIAPFGGDLNCVT 224

  Fly   214 VFGESAGGASTHYMMLTDQTQGLFHRGILQSGSAICPWAYNGDITHNPYRIAKLVGYKGEDNDKD 278
            |||.||||:....::|:....|||||.|.|||....|    |.|..:|:.:|:.:......:...
Human   225 VFGGSAGGSIISGLVLSPVAAGLFHRAITQSGVITTP----GIIDSHPWPLAQKIANTLACSSSS 285

  Fly   279 VLEFLQNVKAKDLIRVEENVLTLEERMNKIMFAFGPSLEPFSTPECVISKPPKEMMKTAWSNSIP 343
            ..|.:|.::.|     |...|.|.:::...::       |.:....|..|.|||::|....:|:|
Human   286 PAEMVQCLQQK-----EGEELVLSKKLKNTIY-------PLTVDGTVFPKSPKELLKEKPFHSVP 338

  Fly   344 MFIGNTSYE---------GLLWVPE-------VKLMPQVLQQLDAGTPFIPKELLATEPSKEKLD 392
            ..:|..::|         |||...|       :.:...||..||     :|.|::.|     .:|
Human   339 FLMGVNNHEFSWLIPRGWGLLDTMEQMSREDMLAISTPVLTSLD-----VPPEMMPT-----VID 393

  Fly   393 SWSAQIRDVH---RTGSESTPDNYMDLCSIYYFVFPALRVVHSRHAYAAGAPVYFYRYDFDSEEL 454
            .:.....|..   :...|...|.::::.::.:          ||:...:|:||:||.:...
Human   394 EYLGSNSDAQAKCQAFQEFMGDVFINVPTVSF----------SRYLRDSGSPVFFYEFQHR---- 444

  Fly   455 IFPYRIMRLGRGVKGVSHADDLSYQF--------SSLLARRLPKESREYRNIERT-VGIWTQFAA 510
              |....::........|..:.::.|        ||.||  .|:.:.|.:.:..| :..||.||.
Human   445 --PSSFAKIKPAWVKADHGAEGAFVFGGPFLMDESSRLA--FPEATEEEKQLSLTMMAQWTHFAR 505

  Fly   511 TGNPYSEKINGMDTLTIDPVRKSDEVIKCLNISDDLKFIDLPEWPKLKVWESLYDDN 567
            ||:|.|:.                                ||.||:....|...:.|
Human   506 TGDPNSKA--------------------------------LPPWPQFNQAEQYLEIN 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est7	NP_524261.1	COesterase	27..514	CDD:278561	164/522 (31%)
		Aes	<116..>221	CDD:223730	53/105 (50%)
CES3	NP_079198.2	COesterase	32..547	CDD:278561	172/577 (30%)
		Aes	<129..>247	CDD:223730	56/120 (47%)
		Prevents secretion from ER. /evidence=ECO:0000255	568..571

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142625
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	216	1.000	Inparanoid score	I3612
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.790