DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est7 and Ces1f

DIOPT Version :9

Sequence 1:	NP_524261.1	Gene:	alpha-Est7 / 40901	FlyBaseID:	FBgn0015575	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_659179.1	Gene:	Ces1f / 234564	MGIID:	2142687	Length:	561	Species:	Mus musculus

Alignment Length:	581	Identity:	181/581 - (31%)
Similarity:	261/581 - (44%)	Gaps:	123/581 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 VADTEYGQVRGIKRLSL--YDVPYFSFEGIPYAQPPVGELRFKAPQRPIPWERVRD-------CS 89
            |.||.:|:|.| |.:::  :..|...|.|||:|:||:|.|||..||...||..|::       ||
Mouse    25 VVDTAHGKVLG-KHVNVEGFSQPVAVFLGIPFAKPPLGSLRFAPPQPAEPWSSVKNATTYPPMCS 88

  Fly    90 QPKDKAVQVQFVFDKV---------EGSEDCLYLNVYT-NNVKPDKARPVMVWIHGGGFIIGEAN 144
            |   .|.:.|.|.|.:         |.||||||||:|| .:...:...||||||||||..:|.|:
Mouse    89 Q---DAARGQAVNDLITNRKEKIHLEFSEDCLYLNIYTPADFSKNSRLPVMVWIHGGGLKLGGAS 150

  Fly   145 REWYGPDYFMKEDVVLVTIQYRLGALGFMSLKSPELNVPGNAGLKDQVLALKWIKNNCASFGGDP 209
             .:.|......|:||:|.|||||...||.|  :.:.:..||.|..|||.||.|:::|.|:|||||
Mouse   151 -SFDGRALSAYENVVVVAIQYRLSIWGFFS--TGDEHSRGNWGHLDQVAALHWVQDNIANFGGDP 212

  Fly   210 NCITVFGESAGGASTHYMMLTDQTQGLFHRGILQSGSAICPWAYNGDITHNPYRIAKLVGYKGED 274
            ..:|:|||||||.|...::|:..::.||||.|.:||.|..|..:..|:.....:||...|.|...
Mouse   213 GSVTIFGESAGGYSVSILILSPLSKNLFHRAISESGVAFIPGMFTKDVRPITEQIAVTAGCKTTT 277

  Fly   275 NDKDVLEFLQNVKAKDLIRVEENVLTLEERMNKIMFAF---GPSLEPFST---PECVISKPPKEM 333
            :...|....|        :.||.:|.:..::|....:.   ..:.:.|.|   ...|:.|.|||:
Mouse   278 SAVIVHCMRQ--------KTEEELLEIMHKLNLYKLSLQGDTKNSDQFVTSVLDGVVLPKDPKEI 334

  Fly   334 MKTAWSNSIPMFIGNTSYE-GLL------WVP-EVKLMPQ----VLQQLDAGTPFIPKELLATEP 386
            :.....|::|..:|....| |.|      ::| :|||..:    :|:|. |....||::::....
Mouse   335 LAEKNFNTVPYIVGINKQECGWLLPTMTGFLPADVKLDKKKAIALLEQF-ASMTGIPEDIIPVAV 398

  Fly   387 SKEKLDSWSAQIRDVHRTGSESTPD----NYMDLCSIYYFVFPALRVVHSRHAYAAGAPVYFYRY 447
            .|             :..||:. ||    ..:|......|..|:  |:.||.....|||.|.|.|
Mouse   399 EK-------------YTKGSDD-PDQIREGVLDAMGDVAFGVPS--VIVSRGHRDTGAPTYMYEY 447

  Fly   448 DFDSEELIFP-YRIMRLGRGVKGVSHADDLSYQFSSLLARRLPKESREYRNIERTV-GIWTQFAA 510
            .:      :| :...:..:.|.| .||||:...|.:.:.|.  ..|.|..|:.:.| ..|..||.
Mouse   448 QY------YPSFSSPQRPKNVVG-DHADDVYSVFGAPILRE--GASEEEINLSKMVMKFWANFAR 503

  Fly   511 TGNPYSEKINGMDTLTIDPVRKSDEVIKCLNISDDLKFIDLPEWPKLKVWESLYDDNKDLL 571
            .|||     ||.                           .||.|||       ||..:..|
Mouse   504 NGNP-----NGK---------------------------GLPHWPK-------YDQKEGYL 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est7	NP_524261.1	COesterase	27..514	CDD:278561	169/522 (32%)
alpha-Est7	NP_524261.1	Aes	<116..>221	CDD:223730	49/105 (47%)
Ces1f	NP_659179.1	COesterase	24..545	CDD:278561	181/581 (31%)
		Aes	<121..>225	CDD:223730	50/106 (47%)
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	558..561
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832948
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.650