Protein Alignment alpha-Est7 and NLGN1

DIOPT Version :9

• Sequence 1: NP_524261.1
• Gene: alpha-Est7 / 40901
• FlyBaseID: FBgn0015575
• Length: 572
• Species: Drosophila melanogaster
• Sequence 2: NP_001352852.1
• Gene: NLGN1 / 22871
• HGNCID: 14291
• Length: 843
• Species: Homo sapiens
• Alignment Length: 579
• Identity: 159/579 - (27%)
• Similarity: 248/579 - (42%)
• Gaps: 132/579 - (22%)

  Fly    20 HKVQQYRQSTNETVVADTEYGQVRGIKRLSLYDV--PYFSFEGIPYAQPPVGELRFKAPQRPIPW 82
            |.:.|.....:..|.  |.:|::||||:....::  |...|.|:|||.||.||.||:.|:.|.||
Human    42 HVLSQKLDDVDPLVA--TNFGKIRGIKKELNNEILGPVIQFLGVPYAAPPTGERRFQPPEPPSPW 104

  Fly    83 ERVRDCSQ-----PK--------DKAVQVQFV--FDKV-----EGSEDCLYLNVYT--------- 118
            ..:|:.:|     |:        :..:.|.|.  .|.|     :.||||||||:|.
Human   105 SDIRNATQFAPVCPQNIIDGRLPEVMLPVWFTNNLDVVSSYVQDQSEDCLYLNIYVPTEDGPLTK 169

  Fly   119 --------NNVKPDK-------ARPVMVWIHGGGFIIGEAN------REWYGPDYFMKEDVVLVT 162
                    |:...|:       .:||||:||||.::.|..|      ...||       :|:::|
Human   170 KQTDDLGDNDGAEDEDIRDSGGPKPVMVYIHGGSYMEGTGNLYDGSVLASYG-------NVIVIT 227

  Fly   163 IQYRLGALGFMSLKSPELNVPGNAGLKDQVLALKWIKNNCASFGGDPNCITVFGESAGGASTHYM 227
            :.||||.|||:|  :.:....||.||.|.:.||:|...|...|||||..|||||..|||:..:.:
Human   228 VNYRLGVLGFLS--TGDQAAKGNYGLLDLIQALRWTSENIGFFGGDPLRITVFGSGAGGSCVNLL 290

  Fly   228 ML---------TDQTQGLFHRGILQSGSAICPWAYNGDITHNPYRIAKLVGYKGEDNDKDVLEF- 282
            .|         ::.|:|||.|.|.|||:|:..||    ::..|.:.|:::..|...|..|.:|.
Human   291 TLSHYSEGNRWSNSTKGLFQRAIAQSGTALSSWA----VSFQPAKYARMLATKVGCNVSDTVELV 351

  Fly   283 --LQNVKAKDLIRVEENVLTLEERMNKIMFAFGPSLEPFSTPECVISKPPKEMMKTAWSNSIPMF 345
              ||....|:|  |::::     :..:...||||.::     ..||...|:.:|:.....:..:.
Human   352 ECLQKKPYKEL--VDQDI-----QPARYHIAFGPVID-----GDVIPDDPQILMEQGEFLNYDIM 404

  Fly   346 IGNTSYEGLLWVPEVKLMPQVLQQLD---AGTPFIP--------KELLATEPSKEKLDSWSAQIR 399
            :|....|||.:|..:......:...|   |.:.|:.        |::| .|..|.....|:
Human   405 LGVNQGEGLKFVENIVDSDDGISASDFDFAVSNFVDNLYGYPEGKDVL-RETIKFMYTDWA---- 464

  Fly   400 DVHRTGSESTPDNYMDLCSIYYFVFPALRV--VHSRHAYAAGAPVYFYRYDFDSEELIFPYRIMR 462
              .|...|:.....:.|.:.:.:|.||:..  :||..    |:|.|||.:....:....|
Human   465 --DRHNPETRRKTLLALFTDHQWVAPAVATADLHSNF----GSPTYFYAFYHHCQTDQVP----- 518

  Fly   463 LGRGVKGVSHADDLSYQF-------SSLLARRLPKESREYRNIERTVGIWTQFAATGNP 514
               .....:|.|::.|..       :.|......|.......:..|  .||.||.||:|
Human   519 ---AWADAAHGDEVPYVLGIPMIGPTELFPCNFSKNDVMLSAVVMT--YWTNFAKTGDP 572

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est7	NP_524261.1	COesterase	27..514	CDD:278561	156/570 (27%)
		Aes	<116..>221	CDD:223730	45/134 (34%)
NLGN1	NP_001352852.1	COesterase	53..626	CDD:365897	157/568 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142646
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740