Protein Alignment alpha-Est7 and NLGN4Y

DIOPT Version :9

• Sequence 1: NP_524261.1
• Gene: alpha-Est7 / 40901
• FlyBaseID: FBgn0015575
• Length: 572
• Species: Drosophila melanogaster
• Sequence 2: NP_001352513.1
• Gene: NLGN4Y / 22829
• HGNCID: 15529
• Length: 836
• Species: Homo sapiens
• Alignment Length: 656
• Identity: 166/656 - (25%)
• Similarity: 268/656 - (40%)
• Gaps: 179/656 - (27%)

  Fly     1 MNKN-LGFVERLRWRLKTIEHKVQQYRQSTNETVVADTEYGQVRGIKRLSLYDV--PYFSFEGIP 62
            :|.| |.::..|..:...|:.:.|.        .|.:|.||:::|::.....::  |...:.|:|
Human    21 LNSNVLLWITALAIKFTLIDSQAQY--------PVVNTNYGKIQGLRTPLPSEILGPVEQYLGVP 77

  Fly    63 YAQPPVGELRFKAPQRPIPWERVRD-------CSQPKDKA----------------VQVQFVFDK 104
            ||.||.||.||:.|:.|..|..:|:       |.|..|:.                ..:.:|.|:
Human    78 YASPPTGERRFQPPESPSSWTGIRNATQFSAVCPQHLDERFLLHDMLPIWFTTSLDTLMTYVQDQ 142

  Fly   105 VEGSEDCLYLNVYT-----NNVK------------PDK-------ARPVMVWIHGGGFIIGEANR 145
               :|||||||:|.     .|:|            .||       .:||||:||||.::.|..|.
Human   143 ---NEDCLYLNIYVPMEDGTNIKRNADDITSNDHGEDKDIHEQNSKKPVMVYIHGGSYMEGTGNM 204

  Fly   146 ------EWYGPDYFMKEDVVLVTIQYRLGALGFMSLKSPELNVPGNAGLKDQVLALKWIKNNCAS 204
                  ..||       :|:::||.||||.|||:|  :.:....||.||.||:.||:||:.|..:
Human   205 IDGSILASYG-------NVIVITINYRLGILGFLS--TGDQAAKGNYGLLDQIQALRWIEENVGA 260

  Fly   205 FGGDPNCITVFGESAGGASTHYMMLTDQTQGLFHRGILQSGSAICPWAYNGDITHNPYRIAKLVG 269
            |||||..:|:||..||.:....:.|:..::|||.:.|:|||:|:..||.|    :.|.:..:::.
Human   261 FGGDPKRVTIFGSGAGASCVSLLTLSHYSEGLFQKAIIQSGTALSSWAVN----YQPAKYTRILA 321

  Fly   270 YKGEDN---DKDVLEFLQNVKAKDLIRVEENVLTLEERMNKIMFAFGPSLEPFSTPECVISKPPK 331
            .|...|   ..|::|.|:|...|:||:......|..       .||||.::     ..||...|:
Human   322 DKVGCNMLDTTDMVECLKNKNYKELIQQTITPATYH-------IAFGPVID-----GDVIPDDPQ 374

  Fly   332 EMMKTAWSNSIPMFIGNTSYEGLLWVPEVKLMPQVLQQLDAGTP---------FIP--------K 379
            .:|:.....:..:.:|....|||      |.:..::...|..||         |:.        |
Human   375 ILMEQGEFLNYDIMLGVNQGEGL------KFVDGIVDNEDGVTPNDFDFSVSNFVDNLYGYPEGK 433

  Fly   380 ELLATEPSKEKLDSWSAQIRDVHRTGSESTPDNYMDLCSIYYFVFPALRV--VHSRHAYAAGAPV 442
            :.| .|..|.....|:      .:...|:.....:.|.:.:.:|.||:..  :|:::    |:|.
Human   434 DTL-RETIKFMYTDWA------DKENPETRRKTLVALFTDHQWVAPAVATADLHAQY----GSPT 487

  Fly   443 YFYRYDFDSEELIFPYRIMRLGRGVKGVSHADDLSYQF-------SSLLARRLPKESREYRNIER 500
            |||.:....:..:.|        .....:|.|::.|.|       :.|.:....|.......:..
Human   488 YFYAFYHHCQSEMKP--------SWADSAHGDEVPYVFGIPMIGPTELFSCNFSKNDVMLSAVVM 544

  Fly   501 TVGIWTQFAATGNPYSEKINGMDTLTIDPVRKSDEVIKCLNISDDLKFI-------DLPEWPKLK 558
            |  .||.||.||:|...                        :..|.|||       :...|.|..
Human   545 T--YWTNFAKTGDPNQP------------------------VPQDTKFIHTKPNRFEEVAWSKYN 583

  Fly   559 VWESLY 564
            ..:.||
Human   584 PKDQLY 589

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est7	NP_524261.1	COesterase	27..514	CDD:278561	151/570 (26%)
		Aes	<116..>221	CDD:223730	48/134 (36%)
NLGN4Y	NP_001352513.1	COesterase	46..610	CDD:306613	160/623 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142830
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840