DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est7 and Ces2e

DIOPT Version :9

Sequence 1:	NP_524261.1	Gene:	alpha-Est7 / 40901	FlyBaseID:	FBgn0015575	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_001093947.1	Gene:	Ces2e / 192257	RGDID:	621563	Length:	557	Species:	Rattus norvegicus

Alignment Length:	602	Identity:	172/602 - (28%)
Similarity:	266/602 - (44%)	Gaps:	150/602 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 GFVERLRWRLKTIEHKVQQYRQSTNETVVADTEYGQVRGIKRLSLYDVP-----YFSFEGIPYAQ 65
            |::..:.|.|..:..:||   ...:.:.:.:|..|||||    |...|.     ..:|.|||:|:
  Rat     8 GWLNAVVWGLLLLFCQVQ---GQDSASPIRNTHTGQVRG----SFVHVKDTKSGVHTFLGIPFAK 65

  Fly    66 PPVGELRFKAPQRPIPWERVRD-------CSQPKD----KAVQVQFVFDKVEGSEDCLYLNVYT- 118
            ||:|.|||..|:.|.||..|||       |.|..|    :.::::.....|..|||||||::||
  Rat    66 PPIGPLRFAPPEPPEPWSGVRDGTSHPAMCLQNIDGLNLENLKIKMSRSPVSMSEDCLYLSIYTP 130

  Fly   119 NNVKPDKARPVMVWIHGGGFIIGEANREWYGPDYFMKEDVVLVTIQYRLGALGFMSLKSPELNVP 183
            .:...|...||||||||||...|.|: .:.|......||||:||||||||.|||.|  :.:.:..
  Rat   131 AHTHKDSNLPVMVWIHGGGLCWGMAS-TYDGSMLAAIEDVVVVTIQYRLGILGFFS--TGDEHAR 192

  Fly   184 GNAGLKDQVLALKWIKNNCASFGGDPNCITVFGESAGGASTHYMMLTDQTQGLFHRGILQSGSAI 248
            ||.|..|||.||:|::.|...|||:|:.:|:|||||||.|....:::..:|||||..|::||.|:
  Rat   193 GNWGYLDQVAALRWVQQNIVHFGGNPDRVTIFGESAGGISVSSHVVSPMSQGLFHGAIMESGVAL 257

  Fly   249 CP--WAYNGDITHNPYRIAKLVGYKGEDNDKDVLEFLQNVKAKDLIRVEENVLTLEERMNKIMFA 311
            .|  .:...::.:.  .:|.|.|.:..|::. ::..|:....::::.:...|.|:...::
  Rat   258 LPNLISNTSEVIYT--MVANLSGCEPVDSEA-LMSCLREKSEEEMLAINNIVRTISGVVD----- 314

  Fly   312 FGPSLEPFSTPECVISKPPKEMMKTAWSNSIPMFIG-NTSYEGLLWVPEVKLMPQVLQQLDAGT- 374
             |..|          .:.|.|::.:...:.:|..|| |:...|  |:..:......:::::..|
  Rat   315 -GKFL----------PRHPLELLASVDFHPVPSIIGINSDEYG--WIIPMLHPDSTMKEINRETM 366

  Fly   375 ----------PFIPKE---LLATEPSKEKLDSWSAQIRDVHRTGSESTPDNYMDLCSIYYFVFPA 426
                      ..:|.|   ||..|...:..||.:.||:             :.::...:.||.||
  Rat   367 RAVLKNTAVQMMLPPECSDLLMEEYMGDTEDSKTLQIQ-------------FNEMMGDFIFVIPA 418

  Fly   427 LRVVHSRHAYAAGAPVYFYRYDFDSEEL--IFPYRIMRLGRGVKGVSHADDLSY----------- 478
            |:|.|.:.::   ||||||.:...|..|  |.|..:.        ..|.|:|.|
  Rat   419 LQVAHFQRSH---APVYFYEFQHQSNFLKDIRPPHVK--------ADHGDELPYVIGYLFWDMKF 472

  Fly   479 ---QFSSLLARRLPKESREYRNIERTVGIWTQFAATGNPYSEKINGMDTLTIDPVRKSDEVIKCL 540
               :...||:|::.|             .|..||..|||.||
  Rat   473 VFTEEEKLLSRKMIK-------------YWANFARHGNPNSE----------------------- 501

  Fly   541 NISDDLKFIDLPEWPKL 557
                     .||.||.|
  Rat   502 ---------GLPYWPAL 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est7	NP_524261.1	COesterase	27..514	CDD:278561	158/536 (29%)
alpha-Est7	NP_524261.1	Aes	<116..>221	CDD:223730	52/105 (50%)
Ces2e	NP_001093947.1	COesterase	30..536	CDD:278561	167/577 (29%)
Ces2e	NP_001093947.1	Aes	<127..>230	CDD:223730	52/105 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336306
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.640