DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est7 and cest-31

DIOPT Version :9

Sequence 1:	NP_524261.1	Gene:	alpha-Est7 / 40901	FlyBaseID:	FBgn0015575	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_504692.3	Gene:	cest-31 / 187304	WormBaseID:	WBGene00019653	Length:	541	Species:	Caenorhabditis elegans

Alignment Length:	538	Identity:	147/538 - (27%)
Similarity:	245/538 - (45%)	Gaps:	102/538 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 VADTEYGQVRGIKRLSLY---DVPYFSFEGIPYAQPPVGELRFKAPQRPIPWERVRDCSQPKDKA 95
            |.::..|.|:|    :||   :.....:.||||||||:|.||||.|.....|...|||::...:.
Worm    16 VLNSTCGPVQG----NLYRHGNEEVHGYLGIPYAQPPIGILRFKKPVSADVWTETRDCTKYGPRC 76

  Fly    96 VQVQFVFDKVE-------GSEDCLYLNVYTN--NVKPDKARPVMVWIHGGGFIIGEANREWYGPD 151
            .....:::.::       ...:||.|||:..  .:|.....|||::||||||.: .|::::.  |
Worm    77 PPSGMLYENLQLPNTDIPDEANCLSLNVFCPQWEIKQSAKHPVMIFIHGGGFEL-SASKDYC--D 138

  Fly   152 YFMK-----EDVVLVTIQYRLGALGFMSLKSPELNVPGNAGLKDQVLALKWIKNNCASFGGDPNC 211
            |.:.     :||::||:.||:|||||  |.:.:.:..||.||.|..|||||:..:.:||||||..
Worm   139 YSLSGTLPLKDVIVVTVNYRVGALGF--LTTGDDSCRGNFGLWDLTLALKWVSTHISSFGGDPKN 201

  Fly   212 ITVFGESAGGASTHYMMLTDQTQGLFHRGILQSGSAICPWAY----NGDITHNPYRIAKLVGYKG 272
            :|:||:|||......:.|:..::.|||:.|:.||||..|:|.    |..:....|  |:..|:.|
Worm   202 VTLFGQSAGAVCADLLNLSPYSRDLFHKLIIMSGSAHVPFAIRTEENQALVCMEY--ARSRGFSG 264

  Fly   273 EDNDKDVLEFLQNVKAKDLIRVEENVLTLEERMNKIMFAFGPSLEPFSTPECVISKPPKEMMKTA 337
             ....::|||.:|:..:.|:  |:..|   :....|..:|.|:|:....|     ||.:|:.:.
Worm   265 -SGSAELLEFFENLPIEKLL--EKTGL---KHTVSIDLSFAPNLDGDFFP-----KPLEELRRE- 317

  Fly   338 WSNSIPMFIGNTSYEGLLWVPEVKLMPQVLQQLDAGTPFIPKELLATEPSKEKLDSWSAQIRDVH 402
             :...|:.:|....|||:                  |.|...:....|      :::..::...:
Worm   318 -TRKKPVIVGMMEDEGLI------------------TAFADGDFTTCE------ENFKRRVESEY 357

  Fly   403 RTGSESTPDN--------YMDLCS----------IYYFVFPALRVVHSRHAYAAGAPVYFYRYDF 449
            |......|:|        |.:.|.          |.:.|:.|..::.:.....||..||||.:||
Worm   358 RGDVVENPENVQKNIMNFYTNYCDESEERKLVDYIGHSVYNAGVLLSAESLARAGNCVYFYVFDF 422

  Fly   450 DSEE------LIFPYRIMRLGRGVKGVSHADDLSYQFSSLLARRLPKESREYRNIERTVGIWTQF 508
            .:.:      .|.|:         ||.:|..:|.|.....:..:.....::.:.:|....::|.|
Worm   423 WNPDGFGPVGSIVPF---------KGAAHCSELRYIIGEGVYSKFDANEKDLKMMEYMTTMFTNF 478

  Fly   509 AATGNPYSEKINGMDTLT 526
            |..|||....:...:|.|
Worm   479 AKYGNPNIPGVTNWETYT 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est7	NP_524261.1	COesterase	27..514	CDD:278561	143/524 (27%)
alpha-Est7	NP_524261.1	Aes	<116..>221	CDD:223730	47/111 (42%)
cest-31	NP_504692.3	COesterase	16..522	CDD:278561	147/538 (27%)
cest-31	NP_504692.3	Aes	<112..>211	CDD:223730	46/103 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm14771
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.720