DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est7 and cest-19

DIOPT Version :9

Sequence 1:	NP_524261.1	Gene:	alpha-Est7 / 40901	FlyBaseID:	FBgn0015575	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_509187.4	Gene:	cest-19 / 180973	WormBaseID:	WBGene00020125	Length:	607	Species:	Caenorhabditis elegans

Alignment Length:	584	Identity:	158/584 - (27%)
Similarity:	242/584 - (41%)	Gaps:	139/584 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 GQVRGIKRLSLYDVPYFSFEGIPYAQPPVGELRFKAPQRPIPWERVRDCSQPKDKAVQVQFVFDK 104
            |.:|| :||......|..|:|||:|.||||.|||:.|:.|..|..|.:.:|  ..|:.:|.:.:.
Worm    33 GAIRG-ERLLTDGQDYSVFKGIPFAMPPVGYLRFQMPKEPAKWRGVMNATQ--YSAMCMQNIDEN 94

  Fly   105 VEG---------SEDCLYLNV-------YTNNVKPDKARPVMVWIHGGGFIIGEANREWYGPDY- 152
            ..|         |||||||||       |||:     ..||:|:||||.|..|.      |.|.
Worm    95 DAGEPERYVAHVSEDCLYLNVFSPTPYQYTND-----TYPVIVFIHGGRFQTGS------GSDIP 148

  Fly   153 -------FMKEDVVLVTIQYRLGALGFMSLKSPELNVPGNAGLKDQVLALKWIKNNCASFGGDPN 210
                   |:...:|.||..||||.|||.|.....|  |||.||.||:.||||:|.|...|||||:
Worm   149 QRAILSNFVSRKIVFVTFNYRLGPLGFASTGDSVL--PGNIGLWDQIWALKWVKANAEVFGGDPS 211

  Fly   211 CITVFGESAGGASTHYMMLTDQTQGLFHRGILQSGSAICP-----------WAYNGDITHNPYRI 264
            .|.:.|...|.||...:.|:.:.:|||.:.:|.||||:.|           |..|.......:..
Worm   212 NILLMGHGTGAASASLLALSPRAEGLFQKVLLMSGSALQPGVVRNTQVNATWNMNDRFGCRAFNS 276

  Fly   265 AKLVGYKGEDNDKDVLEFLQNVKAKDLIRVEENVLTLEERMNKIMFAFGPSLEPFSTPECVISKP 329
            ::|:....:.:.:::.::    |.......||               |.|.::....   ::.:|
Worm   277 SELLDCARKRSKEEIFQY----KRLHFDDYEE---------------FVPIIDGVGG---ILPEP 319

  Fly   330 PKEMMKTAWSNSIPMFIGNTSYEGLLWVPEVKLMPQVLQQLDAGTPFIPKELLATEPSKEKLDSW 394
            |:::  |......|:.||.|..|..|.:       .:|.:.|.....|..|  ..|...:.|...
Worm   320 PEQL--TLHRRKTPIVIGTTKDESSLRI-------LLLNEKDLNFSSITWE--NGETLADNLTLG 373

  Fly   395 SAQIRDVHRTGSESTPDNY----MDLCSIYYFVFPALRVVHSRHAYAAGA------------PVY 443
            ..|.:: ||..|:.....|    :|.......:|.:|..::|...|.|.|            |||
Worm   374 FKQFQN-HRLISQGCKSEYVWTQVDPSFPESVLFNSLLKMYSHFWYDAPASQLATYYLKHDLPVY 437

  Fly   444 FYRYDFDSEELIFPYRIMRLGRGVKGVSHADDLSYQFSSLLARRLPKESREYRNIERTVGIWTQ- 507
            .|.:|..||..   |.|.|...||..: |..:::.:|.:      .::...::..:|.|.|:::
Worm   438 LYSFDHISENF---YDIDRAFHGVDKL-HIFNVTPRFLN------KRKDMNWQLDQRVVEIFSEL 492

  Fly   508 ---FAATGNPYSE----KINGMDTLTIDPVRKSDEVIKCLNISDDLKFIDLPEWPKLKV---WE 561
               ||..|.|..|    ..|...|                 .:.:|.::.:.:.|.::|   |:
Worm   493 VANFALYGTPTHENDGFSFNWTST-----------------TAKELSYLSITDSPSMQVGYRWQ 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est7	NP_524261.1	COesterase	27..514	CDD:278561	150/528 (28%)
alpha-Est7	NP_524261.1	Aes	<116..>221	CDD:223730	48/119 (40%)
cest-19	NP_509187.4	Abhydrolase	27..544	CDD:389770	158/584 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810