DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est7 and cest-1.1

DIOPT Version :9

Sequence 1:	NP_524261.1	Gene:	alpha-Est7 / 40901	FlyBaseID:	FBgn0015575	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_506506.1	Gene:	cest-1.1 / 179915	WormBaseID:	WBGene00011362	Length:	673	Species:	Caenorhabditis elegans

Alignment Length:	504	Identity:	124/504 - (24%)
Similarity:	211/504 - (41%)	Gaps:	109/504 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 FEGIPYAQPPVGELRFKAPQRPIPWERVRDCSQPKDKAVQ--VQFVFDKVEG--SEDCLYLNVYT 118
            |.|||:.:||:|:||::.|:.|..||.|...::.|...:.  .:...:|..|  |||||||||.|
Worm    46 FLGIPFVEPPIGDLRYRKPRPPKSWEGVLVTNEYKSACMSNATKTYKNKFGGPISEDCLYLNVLT 110

  Fly   119 NN-VKPDKARPVMVWIHGGGFIIGEANREWYGPDYFMK------EDVVLVTIQYRLGALGFMSLK 176
            |. ...:|...||:.:||||::...|:.  :.|:..:.      .::|:||..||||...|....
Worm   111 NEYCLENKNCSVMMIVHGGGYLTESAST--FNPEILINNFVGQGRNIVVVTFNYRLGLFSFGQFN 173

  Fly   177 SPELNVPGNAGLKDQVLALKWIKNNCASFGGDPNCITVFGESAGGASTHYMMLTDQTQGLFHRGI 241
            ....:  .|.||.|.:.::.|::....:|||:.|.||:.|.|||.:.......:..|:||.|:.|
Worm   174 GDRGD--KNFGLYDMIESVNWVRREIENFGGNKNRITLAGHSAGASMIVAFTSSPLTKGLVHQQI 236

  Fly   242 LQSGSAICPWAYNGDITHNPYR--------IAKLVGYKGED------NDKDVLEFLQNVKAKDLI 292
            :.|          ..:|:...:        :|::||...|:      :::.|......::.|...
Worm   237 IMS----------APMTNMSKKSNFKGMTVMAQMVGCLSEEIGFNKLSEEQVENTYSCLRKKSAQ 291

  Fly   293 RVEENVLTLEERMNKIMFAFGPSLEPFSTPECVISKPPKEMMKTAWSNSIPMFIGNTSYEGLLWV 357
            ::.:..|.|.:  |...|...|.::     |..::..|:.:..:.....|...||.|:.|    |
Worm   292 QILDAQLWLLQ--NSTYFLGAPPID-----EHFLTDYPENLYASKSIYPINTLIGTTTLE----V 345

  Fly   358 PE-------------VKLMPQVLQQLDAGTPFIPKELLATEPSKEKLDSWSAQIRDVHRTGSEST 409
            .|             |:|:..:...:.        .:|..||     :::|.:.:..:..|:.|
Worm   346 EESSYIIDPAFADKKVELLENLCDHIG--------YVLYEEP-----ETFSKKCQKQYMNGNSS- 396

  Fly   410 PDNYMDLCSIYYFVFPALRVVHSRHAYAAGAPVYFYRYDFDSEELIFPYRIMRLGRG-------- 466
                |:|.:...|..||:....| |. :....|:.|.||         ||    |.|
Worm   397 ----MNLSNEMEFYTPAIDFADS-HT-SGNTKVFLYSYD---------YR----GAGPAYDRYLE 442

  Fly   467 VKGVSHADDLSYQFSSLLARRLPKESREYRNIERTV-GIWTQFAATGNP 514
            |:...|::||.|.|.:......||:    ..||:.. |::..|....||
Worm   443 VRSPHHSEDLIYVFGTHRGIFAPKD----YIIEKIYSGMFADFVNFENP 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est7	NP_524261.1	COesterase	27..514	CDD:278561	122/502 (24%)
alpha-Est7	NP_524261.1	Aes	<116..>221	CDD:223730	34/111 (31%)
cest-1.1	NP_506506.1	COesterase	19..531	CDD:278561	124/504 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157091
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740