DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est7 and cest-32

DIOPT Version :9

Sequence 1:	NP_524261.1	Gene:	alpha-Est7 / 40901	FlyBaseID:	FBgn0015575	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_504397.1	Gene:	cest-32 / 178909	WormBaseID:	WBGene00016862	Length:	545	Species:	Caenorhabditis elegans

Alignment Length:	496	Identity:	140/496 - (28%)
Similarity:	226/496 - (45%)	Gaps:	81/496 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 GIPYAQPPVGELRFKAPQRPIPWERVRDCSQPKDKAVQVQFVFDKV------EGSED-CLYLNVY 117
            |||:|:.|:.|||||.|.....|.:..:|.:......|...:...:      |.:|| ||.||::
Worm    41 GIPFAKAPICELRFKKPVEAEKWTKPLNCHKYGPGCPQSGHMISNLLPPGYREFAEDNCLNLNIF 105

  Fly   118 TNNVKPDK---ARPVMVWIHGGGFIIGEANREWYGPDYFMK-----EDVVLVTIQYRLGALGFMS 174
            ..:.|.::   ..|:||:.|||||.||.::   ...||.:.     :||::||..||:|.||||:
Worm   106 APSWKSEEFPNGLPIMVYFHGGGFEIGFSS---MFDDYSLSGTLPLKDVIVVTANYRVGPLGFMT 167

  Fly   175 LKSPELNVPGNAGLKDQVLALKWIKNNCASFGGDPNCITVFGESAGGASTHYMMLTDQTQGLFHR 239
             ...|:: .||.||.||.|||||::.:..||||:||.:||.|.||||.|...:.|:..:..||||
Worm   168 -TGDEVS-RGNYGLWDQTLALKWVQEHIKSFGGNPNIVTVCGTSAGGVSAGLLALSPHSNKLFHR 230

  Fly   240 GILQSGSAICPWA-----YNGDITHNPYRIAKLVGYKGEDNDKDVLEFLQNVKAKDLIRVEENVL 299
            .:..||||.|.::     ...:|..|   .||..||:|||::    ..|:..|::.|.:.:|..
Worm   231 FMAMSGSAFCEFSIRTKEQEAEIFRN---FAKHHGYEGEDSE----SLLEWYKSQPLSKFQETA- 287

  Fly   300 TLEERMNKIMFAFGPSLE------PFSTPECVISKPPKEMMKTAWSNSIPMFIGNTSYEGL--LW 356
            |.|::.:..: .|.|:.:      ||.  |.....|..:.|.|.           ..||||  |.
Worm   288 TFEKKASGFL-TFIPNFDGDFFPKPFD--ELSREAPKLDAMATV-----------DEYEGLGFLT 338

  Fly   357 VPEVKLMPQVLQQLDAGTPFIPKELLATEPSKEKLDSWSAQIRDVHRTGSESTPDNYMDLCSIYY 421
            :.:.:.....:.:...|:..:..   |.:..|..::.:   ::::.:...::.....:.|.|..:
Worm   339 MFQSRRNDMDIIKSSFGSDVVEN---AVDVQKRIMEFY---MKNIDKNDDKAVEKRLIQLISDSW 397

  Fly   422 FVFPALRVVHSRHAYAAGAPVYFYRYDF------DSEELIFPYRIMRLGRGVKGVSHADDLSYQF 480
            |...||..|.:...|  |:..|...:|:      |.....||:         |..:|..:|.|..
Worm   398 FNIGALETVKTSTKY--GSNAYLGSFDYYNMGSNDPYATWFPF---------KAANHGSELKYML 451

  Fly   481 SSLLARRLPKESREYRNIERTVGIWTQFAATGNPYSEKING 521
            ...:.:..|.| .|::.|:....:...|...|||  ..|||
Worm   452 GEGMGKFSPIE-EEFKVIDMMGTLTANFVKYGNP--NGING 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est7	NP_524261.1	COesterase	27..514	CDD:278561	135/487 (28%)
alpha-Est7	NP_524261.1	Aes	<116..>221	CDD:223730	47/112 (42%)
cest-32	NP_504397.1	COesterase	15..516	CDD:278561	140/496 (28%)
cest-32	NP_504397.1	Aes	<104..>227	CDD:223730	51/127 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157254
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.640