DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est7 and cest-5.2

DIOPT Version :9

Sequence 1:	NP_524261.1	Gene:	alpha-Est7 / 40901	FlyBaseID:	FBgn0015575	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_501021.3	Gene:	cest-5.2 / 177428	WormBaseID:	WBGene00015284	Length:	583	Species:	Caenorhabditis elegans

Alignment Length:	516	Identity:	124/516 - (24%)
Similarity:	193/516 - (37%)	Gaps:	142/516 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 VADTEYGQVRGIKRLSLYDVPYFSFEGIPYAQPPVGELRFKAPQRPIPWERVRDC---------- 88
            :..|..|::.| |:...|.:    |..||:|:||:|.|||:.|:....|..|.:.
Worm    23 IIKTSLGRLEG-KQSGKYQL----FRRIPFAKPPIGTLRFQKPESAEKWNGVWNATEYGPACMSN 82

  Fly    89 ---SQPKDKAVQVQFVFDKVEGSEDCLYLNVYTNN-VKPDKARPVMVWIHGGGFIIGEA--NREW 147
               :|...|.|           .||||::|::|:: ....|...|:|:||||..:...|  ..:.
Worm    83 STWTQSPQKWV-----------DEDCLHVNIFTSDKCLKSKDCAVVVYIHGGEIVFDSAVMFNDT 136

  Fly   148 YGPDYFMKEDVVLVTIQYRLGALGFMSLKSPELNVPGNAGLKDQVLALKWIKNNCASFGGDPNCI 212
            :..:.|:|:||:||...:|||.....::....: .|.|..|.|.:||.:::|:...:||||...|
Worm   137 FLLESFVKQDVILVIPAFRLGIFSHFTVHDQNI-APNNLALYDIILAQEFVKSEIHNFGGDIQKI 200

  Fly   213 TVFGESAGGASTHYMMLT---DQTQGLFHRGILQSGSAICPWAYNGDITHNPYRIAKLVGYKG-- 272
            |:||.|.||.....|..:   :|...||.|.|:.|.:     .|...:.....|..::|.:.|
Worm   201 TLFGHSYGGTIASMMAFSSEINQDLSLFQRIIVMSAN-----QYFDTLEEQIERSDRVVKHAGCS 260

  Fly   273 -----------EDNDKDVLEFLQNVKAKDLIRVEENVLTLEER---------MNKIMFAFGPSLE 317
                       ...:|.:::.||.:...:|:.|:.   :|||.         :...:|....|||
Worm   261 VPTNLARKMNRSQKEKYMMKCLQKLSGMELLSVQR---SLEEAGYPDIGNLVLRGPLFPDVTSLE 322

  Fly   318 PFSTPECVISKPPKEMMKTAWSNSIPMFIGNTSYEGLLWVPEVKLMPQVLQQLDAGTPFIPKELL 382
            ...:|:                 .|||..|.|.:|               ...:..|.||.|...
Worm   323 MLESPK-----------------MIPMLAGCTKFE---------------SDDEDETHFIGKHFG 355

  Fly   383 ATEPSKEKLDSWSAQIRDVHRTGSES---TPDNYMDLCSIYYFVFPALRVVHSR-HAYAAGAPVY 443
            ...|         .:..:.:|...|:   ...|:.|.... ..|...|||...| |    |.|.|
Worm   356 LENP---------IECDEKYRKDLENGIFDRQNHSDKTQA-IMVPTKLRVDQLRKH----GVPAY 406

  Fly   444 FYRYDFDSEELIFPYRIMRLGRGVKGVSHADDLSYQFSSLLARRLPKESRE------YRNI 498
            .|       |..:|          |...|.|||.|...   .....|:..|      |||:
Worm   407 LY-------EFTYP----------KHAFHTDDLYYIMG---IHPFEKDENEEHLEKVYRNM 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est7	NP_524261.1	COesterase	27..514	CDD:278561	124/516 (24%)
alpha-Est7	NP_524261.1	Aes	<116..>221	CDD:223730	34/107 (32%)
cest-5.2	NP_501021.3	Abhydrolase	23..498	CDD:389770	124/516 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156893
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.740