DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est7 and Ces2c

DIOPT Version :9

Sequence 1:	NP_524261.1	Gene:	alpha-Est7 / 40901	FlyBaseID:	FBgn0015575	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_598270.2	Gene:	Ces2c / 171118	RGDID:	621510	Length:	561	Species:	Rattus norvegicus

Alignment Length:	586	Identity:	180/586 - (30%)
Similarity:	260/586 - (44%)	Gaps:	125/586 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 RQSTNETVVADTEYGQVRG-IKRLSLYDVPYFSFEGIPYAQPPVGELRFKAPQRPIPWERVRD-- 87
            :.|...:.:..|..||||| :..:........:|.|||:|:.|||.|||..|:.|.||..|||
  Rat    27 QDSPESSSIRTTHTGQVRGKLDHVRDTKAGVHTFLGIPFAKAPVGPLRFAPPEDPEPWSGVRDGT 91

  Fly    88 -----CSQPKDKAVQV-----QFVFDKVEGSEDCLYLNVYTNNVKPDKAR-----PVMVWIHGGG 137
                 |.|..|...:|     :.:...:..||||||||:||    |..|.     ||||.||||.
  Rat    92 SHPAMCLQNIDMLDEVGLTDMKMILSSIPMSEDCLYLNIYT----PAHAHEGSNLPVMVCIHGGA 152

  Fly   138 FIIGEANREWYGPDYFMKEDVVLVTIQYRLGALGFMSLKSPELNVPGNAGLKDQVLALKWIKNNC 202
            .:||.|:. ..|....:.||:|:|.||||||.|||.|  :.:.:..||.|..|||.||:|::.|.
  Rat   153 LVIGMASM-CDGSLLAVNEDLVVVAIQYRLGVLGFFS--TGDEHARGNWGYLDQVAALRWVQQNI 214

  Fly   203 ASFGGDPNCITVFGESAGGASTHYMMLTDQTQGLFHRGILQSGSAICPWAYNGDITHNPYRIAKL 267
            |.|||:||.:|:||.||||.|....:::..:|||||..|::||.|:.|...:.........:|||
  Rat   215 AHFGGNPNRVTIFGVSAGGTSVSSHVISPMSQGLFHGAIMESGVALLPDLISETSETVSTTVAKL 279

  Fly   268 VGYKGEDNDKDVLEFLQNVKAKDLIRVEENVLTLEERMNKIMFAFGPSLEPFSTPECVISKPPKE 332
            .|.:..|::    ..::.::||.    ...:|.:    ||:.     .:.|.......:.:.|||
  Rat   280 SGCEATDSE----TLVRCLRAKS----GAEILVI----NKVF-----KMIPAVVDGEFLPRHPKE 327

  Fly   333 MMKTAWSNSIPMFIGNTSYEGLLWVPEVKLMPQVLQQLD-----------AGTPFIPKE---LLA 383
            ::.:...:.:|..||..:.|....:|.|....|::::|.           |....:|.|   ||.
  Rat   328 LLASEDFHPVPSIIGVNTDEYCCTIPMVMGTAQIIKELSRENLQAVLKDTAAQMMLPPECGDLLM 392

  Fly   384 TEPSKEKLDSWSAQIRDVHRTGSESTPDNYMDLCSIYYFVFPALRVVHSRHAYAAGAPVYFYRYD 448
            .|......|..:.||:             |.::...:.||.|||:|.|.:.::   |||||  |:
  Rat   393 EEYMGNTDDPQTLQIQ-------------YAEMMGDFLFVIPALQVAHFQRSH---APVYF--YE 439

  Fly   449 FDSEELIF-----PYRIMRLGRGVKGVSHADDLSYQFSS--------------LLARRLPKESRE 494
            |......|     |:        || ..|||::.:.|.|              ||:||:.|
  Rat   440 FQHAPSYFKNVRPPH--------VK-ADHADEVPFVFGSFFWGIKVDFTEEEKLLSRRMMK---- 491

  Fly   495 YRNIERTVGIWTQFAATGNPYSEKINGMDTLTIDPVRKSDEVIKCLN----ISDDLKFIDLPEWP 555
                     .|..||..|||.||      .|...||...||....|:    :...||...|..|.
  Rat   492 ---------YWANFARHGNPNSE------GLPYWPVLDHDEQYLQLDTQPAVDRALKARRLQFWT 541

  Fly   556 K 556
            |
  Rat   542 K 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est7	NP_524261.1	COesterase	27..514	CDD:278561	165/537 (31%)
alpha-Est7	NP_524261.1	Aes	<116..>221	CDD:223730	51/109 (47%)
Ces2c	NP_598270.2	COesterase	32..540	CDD:395084	177/577 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820