DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est7 and Ces1c

DIOPT Version :9

Sequence 1:	NP_524261.1	Gene:	alpha-Est7 / 40901	FlyBaseID:	FBgn0015575	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_031980.2	Gene:	Ces1c / 13884	MGIID:	95420	Length:	554	Species:	Mus musculus

Alignment Length:	575	Identity:	163/575 - (28%)
Similarity:	260/575 - (45%)	Gaps:	122/575 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 VADTEYGQVRGIKRLSL--YDVPYFSFEGIPYAQPPVGELRFKAPQRPIPWERVRD-------CS 89
            |.||..|:|.| |.:||  ::.|...|.|:|:|:||:|.|||..||...||..|::       ||
Mouse    25 VVDTTQGKVLG-KYISLEGFEQPVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNATSYPPMCS 88

  Fly    90 QPKD--KAVQVQFVFDK----VEGSEDCLYLNVYT-NNVKPDKARPVMVWIHGGGFIIGEANREW 147
            |...  |.:...|..:|    ::.||||||||:|: .::......||||||||||.:||.|: .:
Mouse    89 QDAGWAKILSDMFSTEKEILPLKISEDCLYLNIYSPADLTKSSQLPVMVWIHGGGLVIGGAS-PY 152

  Fly   148 YGPDYFMKEDVVLVTIQYRLGALGFMSLKSPELNVPGNAGLKDQVLALKWIKNNCASFGGDPNCI 212
            .|......|:||:||||||||..|..|  :.:.:.|||....||:.||:|:::|.|:|||:|:.:
Mouse   153 NGLALSAHENVVVVTIQYRLGIWGLFS--TGDEHSPGNWAHLDQLAALRWVQDNIANFGGNPDSV 215

  Fly   213 TVFGESAGGASTHYMMLTDQTQGLFHRGILQSGSAICPWAYNGDI-THNPYRIAKLVGYKGEDND 276
            |:||||:||.|...::|:...:.||||.|.:||..|     |.:: ..|...:.:::....:.||
Mouse   216 TIFGESSGGISVSVLVLSPLGKDLFHRAISESGVVI-----NTNVGKKNIQAVNEIIATLSQCND 275

  Fly   277 KDVLEFLQNVKAKDLIRVEENVLTLEERMNKIMFAFGPSLEPFSTPECVISKPPKEMMKTAWSNS 341
            ......:|.::.|    .|..:|.:..::.:...:....::     ..|:.|.|:|::.....|:
Mouse   276 TSSAAMVQCLRQK----TESELLEISGKLVQYNISLSTMID-----GVVLPKAPEEILAEKSFNT 331

  Fly   342 IPMFIGNTSYEGLLWVPEVKLMPQVLQQLDAGTPFIPKELLATEPSKEKLDSWSAQ--------- 397
            :|..:|....| ..|:     :|.:||.|      :|:..:..|.:...|..:.::
Mouse   332 VPYIVGFNKQE-FGWI-----IPMMLQNL------LPEGKMNEETASLLLRRFHSELNISESMIP 384

  Fly   398 ------IRDVHRTGSESTPDNYMDLCSIYYFVFPALRVVHSRHAYAAGAPVYFYRYDFDSEELIF 456
                  :|.|.....:|  :..:|:....:|..||  |:.||....||...|.|.         |
Mouse   385 AVIEQYLRGVDDPAKKS--ELILDMFGDIFFGIPA--VLLSRSLRDAGVSTYMYE---------F 436

  Fly   457 PYRIM----RLGRGVKGVSHADDLSYQFSSLLARRLPKESREYRNIERTV-GIWTQFAATGNPYS 516
            .||..    :..:.|:| .|.|::.:.|.:.|.:.  ..|.|..|:.:.| ..|..||..|||..
Mouse   437 RYRPSFVSDKRPQTVEG-DHGDEIFFVFGAPLLKE--GASEEETNLSKMVMKFWANFARNGNPNG 498

  Fly   517 EKINGMDTLTIDPVRKSDEVIKCLNISDDLKFIDLPEWPKLKVWESLYDDNKDLL 571
            |                                .||.||:       ||:.:..|
Mouse   499 E--------------------------------GLPHWPE-------YDEQEGYL 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est7	NP_524261.1	COesterase	27..514	CDD:278561	153/516 (30%)
alpha-Est7	NP_524261.1	Aes	<116..>221	CDD:223730	47/105 (45%)
Ces1c	NP_031980.2	Esterase_lipase	25..525	CDD:238191	163/575 (28%)
		Aes	<121..>234	CDD:223730	51/115 (44%)
		Prevents secretion from ER. /evidence=ECO:0000255	551..554
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832570
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.650