DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est7 and Bche

DIOPT Version :9

Sequence 1:	NP_524261.1	Gene:	alpha-Est7 / 40901	FlyBaseID:	FBgn0015575	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	XP_011238302.1	Gene:	Bche / 12038	MGIID:	894278	Length:	615	Species:	Mus musculus

Alignment Length:	575	Identity:	169/575 - (29%)
Similarity:	270/575 - (46%)	Gaps:	81/575 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 RQSTNETVVADTEYGQVRGIKRLSLYDVPYFSFEGIPYAQPPVGELRFKAPQRPIPWERVRDCSQ 90
            :..|.|..:..|:.|:|||:. :.:......:|.||||||||:|.||||.||....|..:.:.:|
Mouse    38 KSHTEEDFIITTKTGRVRGLS-MPVLGGTVTAFLGIPYAQPPLGSLRFKKPQPLNKWPDIHNATQ 101

  Fly    91 PKDKAVQ-VQFVFDKVEG----------SEDCLYLNVYTNNVKPDKARPVMVWIHGGGFIIGEAN 144
            ..:...| :...|...:|          |||||||||:....||..| .|||||:||||..|.::
Mouse   102 YANSCYQNIDQAFPGFQGSEMWNPNTNLSEDCLYLNVWIPVPKPKNA-TVMVWIYGGGFQTGTSS 165

  Fly   145 REWYGPDYFMK-EDVVLVTIQYRLGALGFMSLK-SPELNVPGNAGLKDQVLALKWIKNNCASFGG 207
            ...|...:..: |.|::|::.||:|||||::.. :|:  .|||.||.||.|||:|::.|.|:|||
Mouse   166 LPVYDGKFLARVERVIVVSMNYRVGALGFLAFPGNPD--APGNMGLFDQQLALQWVQRNIAAFGG 228

  Fly   208 DPNCITVFGESAGGASTHYMMLTDQTQGLFHRGILQSGSAICPWA--YNGDITHNPYRIAKLVGY 270
            :|..||:||||||.||....:|..|:..||.|.||:|||:..|||  :..:..:....:||..|.
Mouse   229 NPKSITIFGESAGAASVSLHLLCPQSYPLFTRAILESGSSNAPWAVKHPEEARNRTLTLAKFTGC 293

  Fly   271 KGEDNDKDVLEFLQNVKAKDLIRVEENVLTLEERMNKIMFAFGPSLE-PFSTPECVISKPPKEMM 334
             .::|:.::::.|::...::::|.|..||..:..::   ..|||::: .|      ::..|..::
Mouse   294 -SKENEMEMIKCLRSKDPQEILRNERFVLPSDSILS---INFGPTVDGDF------LTDMPHTLL 348

  Fly   335 KTAWSNSIPMFIGNTSYEGLLWVPEVKLMPQVLQQLDAGTPFIPKELLATEPSKEKLDSWSAQIR 399
            :........:.:|....||..:             |..|.|...|:..:....||..:..:....
Mouse   349 QLGKVKKAQILVGVNKDEGTAF-------------LVYGAPGFSKDNDSLITRKEFQEGLNMYFP 400

  Fly   400 DVHRTGSES------------TPDNYM----DLCSIYYFVFPALRVVHSRHAYAAGAPVYFYRYD 448
            .|.|.|.|:            :|:.|.    |:...|..:.|||............|  :||.::
Mouse   401 GVSRLGKEAVLFYYVDWLGEQSPEVYRDALDDVIGDYNIICPALEFTKKFAELENNA--FFYFFE 463

  Fly   449 FDSEELIFPYRIMRLGRGVKGVSHADDLSYQFSSLLARRLPKESRE---YRNIERTVGIWTQFAA 510
            ..|.:|.:|..:        ||.|..::.:.|...|.||:.....|   .|:|.:|   |..||.
Mouse   464 HRSSKLPWPEWM--------GVMHGYEIEFVFGLPLGRRVNYTRAEEIFSRSIMKT---WANFAK 517

  Fly   511 TGNPYSEKINGMDTLTIDPVRKSDEVIKCLNI-SDDLKFIDLPEWPKLKVWESLY 564
            .|:|...:.|.    |:.||..|.|. |.|.: ::..|.......|:.:.|...:
Mouse   518 YGHPNGTQGNS----TMWPVFTSTEQ-KYLTLNTEKSKIYSKLRAPQCQFWRLFF 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est7	NP_524261.1	COesterase	27..514	CDD:278561	157/521 (30%)
alpha-Est7	NP_524261.1	Aes	<116..>221	CDD:223730	50/106 (47%)
Bche	XP_011238302.1	COesterase	46..563	CDD:365897	166/561 (30%)
Bche	XP_011238302.1	AChE_tetra	578..612	CDD:370053
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810