DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est7 and clt

DIOPT Version :9

Sequence 1:	NP_524261.1	Gene:	alpha-Est7 / 40901	FlyBaseID:	FBgn0015575	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_536784.1	Gene:	clt / 117300	FlyBaseID:	FBgn0000326	Length:	562	Species:	Drosophila melanogaster

Alignment Length:	557	Identity:	198/557 - (35%)
Similarity:	299/557 - (53%)	Gaps:	54/557 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 VVADTEYGQVRGIKRLSLYDVPYFSFEGIPYAQPPVGELRFKAPQRPIPWERVR----DCSQPKD 93
            |....:.|.:.|.::..:..:.|.||.|:|||:||||||||::|:   |.||.:    |||:..:
  Fly    20 VKVPVKQGVLVGRQKKLVNGLEYNSFLGVPYAEPPVGELRFRSPR---PLERFQKQELDCSKEGN 81

  Fly    94 KAVQVQFVFDKVEGSEDCLYLNVYTNNVKPDKA-RPVMVWIHGGGFIIGEANREWYGPDYFMKED 157
            .:.|......:|.||||||:||||...||..:. .|||||||||||..|..|.:::.|...|:::
  Fly    82 VSYQRDPFTLEVAGSEDCLFLNVYAPKVKSTRTPLPVMVWIHGGGFFFGNGNSDFHFPAKLMEQE 146

  Fly   158 VVLVTIQYRLGALGFMSLKSPELNVPGNAGLKDQVLALKWIKNNCASFGGDPNCITVFGESAGGA 222
            |::||:.||||||||:||  ||..:.||.|||||.|||:|::.|.|||.||||.:|:|||||||:
  Fly   147 VIVVTLNYRLGALGFLSL--PEEGIHGNMGLKDQRLALEWVQENIASFNGDPNNVTLFGESAGGS 209

  Fly   223 STHYMMLTDQTQGLFHRGILQSGSAICPWAYNGDITHNPYRIAKLVGYKGED---NDKDVLEFLQ 284
            |.|........:.|||:.|:|||:|...|.:..:......|:|:|:|  |.|   :.|.:|.|||
  Fly   210 SVHLHTFARHAKRLFHKAIMQSGTANMEWVFQNEAPAKTRRLAELLG--GGDFGGDSKALLTFLQ 272

  Fly   285 NVKAKD--LIRVEENVLTLEERMNKIMFAFGPSLEPFSTPECVISKPPKEMM-KTAWSNSIPMFI 346
            :.||..  ::.....||:.:||...:.|||.|.:|..|:|:..:.:...|:| |.....|:|:.:
  Fly   273 SEKATPTAILANTLKVLSPDERRRHLPFAFKPVVEDSSSPDRFLEQDIMELMHKKDCLGSMPVIM 337

  Fly   347 GNTSYEGLLWVPEVKLMPQVLQQLDAG----TPFIPKELLATEPSKEKLDSWSAQIRDVHRTG-- 405
            |..|.|||..|.:.|      |:|:|.    ...:|:.|: .:|...:....::.||.....|
  Fly   338 GYNSAEGLAIVVKAK------QKLEAYEDDLARLVPRNLV-LDPQAPEAQEAASDIRAFFFNGQA 395

  Fly   406 -SESTPDNYMDLCSIYYFVFPALRVVHSRHAYAAGAPVYFYRYDFDSEELIFPYRIMRLGRGVKG 469
             |:...||.:||.|.|:|.....|.|....:....:|:||||.|:.....:  |:.:.....::|
  Fly   396 LSKENMDNLVDLFSDYHFSMDLQRAVEIHASCQTQSPLYFYRLDYVGGRNL--YKKIFQNEDLRG 458

  Fly   470 VSHADDLSYQFSSLLARRLPKESREYRNI-ERTVGIWTQFAATG------NPYSEKINGMDTLTI 527
            |:||||:.|.|.  :|....:.:|:...: ||...:|..||..|      .|..:..||
  Fly   459 VAHADDICYLFQ--MAGDETEMNRDDLMVTERLCEMWANFARDGKPSPIWKPVKKPHNG------ 515

  Fly   528 DPVRKSDEVIKCLNISDDLKFIDLPEWPKLKVWESLY 564
            :|::     :.||.|..:||....|:..::..|.|:|
  Fly   516 EPIQ-----LDCLLIDRELKMCSNPDGERMDFWRSMY 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est7	NP_524261.1	COesterase	27..514	CDD:278561	185/505 (37%)
alpha-Est7	NP_524261.1	Aes	<116..>221	CDD:223730	59/105 (56%)
clt	NP_536784.1	COesterase	22..543	CDD:278561	194/549 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	222	1.000	Domainoid score	I1478
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	226	1.000	Inparanoid score	I2231
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	8	7.870