DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est7 and Nlgn1

DIOPT Version :9

Sequence 1:	NP_524261.1	Gene:	alpha-Est7 / 40901	FlyBaseID:	FBgn0015575	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	XP_038957495.1	Gene:	Nlgn1 / 116647	RGDID:	621117	Length:	863	Species:	Rattus norvegicus

Alignment Length:	599	Identity:	163/599 - (27%)
Similarity:	250/599 - (41%)	Gaps:	152/599 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 HKVQQYRQSTNETVVADTEYGQVRGIKRLSLYDV--PYFSFEGIPYAQPPVGELRFKAPQRPIPW 82
            |.:.|.....:..|.  |.:|::||||:....::  |...|.|:|||.||.||.||:.|:.|.||
  Rat    42 HVLSQKLDDVDPLVT--TNFGKIRGIKKELNNEILGPVIQFLGVPYAAPPTGEHRFQPPEPPSPW 104

  Fly    83 ERVRDCSQ-----PK--------DKAVQVQFV--FDKV-----EGSEDCLYLNVY--TNNV---- 121
            ..:|:.:|     |:        :..:.|.|.  .|.|     :.||||||||:|  |.:|
  Rat   105 SDIRNATQFAPVCPQNIIDGRLPEVMLPVWFTNNLDVVSSYVQDQSEDCLYLNIYVPTEDVKRIS 169

  Fly   122 -----KPDK---------------------------------ARPVMVWIHGGGFIIGEAN---- 144
                 ||.|                                 .:||||:||||.::.|..|
  Rat   170 KECARKPGKKICRKGGPLTKTQTDDLGDNDRAEDEDIRDSGGPKPVMVYIHGGSYMEGTGNLYDG 234

  Fly   145 --REWYGPDYFMKEDVVLVTIQYRLGALGFMSLKSPELNVPGNAGLKDQVLALKWIKNNCASFGG 207
              ...||       :|:::|:.||||.|||:|  :.:....||.||.|.:.||:|...|...|||
  Rat   235 SVLASYG-------NVIVITVNYRLGVLGFLS--TGDQAAKGNYGLLDLIQALRWTSENIGFFGG 290

  Fly   208 DPNCITVFGESAGGASTHYMML---------TDQTQGLFHRGILQSGSAICPWAYNGDITHNPYR 263
            ||..|||||..|||:..:.:.|         ::.|:|||.|.|.|||:|:..||    ::..|.:
  Rat   291 DPLRITVFGSGAGGSCVNLLTLSHYSEGNRWSNSTKGLFQRAIAQSGTALSSWA----VSFQPAK 351

  Fly   264 IAKLVGYKGEDNDKDVLEF---LQNVKAKDLIRVEENVLTLEERMNKIMFAFGPSLEPFSTPECV 325
            .|:::..|...|..|.:|.   ||....|:|  |:::|     :..:...||||.::     ..|
  Rat   352 YARILATKVGCNVSDTVELVECLQKKPYKEL--VDQDV-----QPARYHIAFGPVID-----GDV 404

  Fly   326 ISKPPKEMMKTAWSNSIPMFIGNTSYEGLLWVPEVKLMPQVLQQLD---AGTPFIP--------K 379
            |...|:.:|:.....:..:.:|....|||.:|..:......:...|   |.:.|:.        |
  Rat   405 IPDDPQILMEQGEFLNYDIMLGVNQGEGLKFVENIVDSDDGVSASDFDFAVSNFVDNLYGYPEGK 469

  Fly   380 ELLATEPSKEKLDSWSAQIRDVHRTGSESTPDNYMDLCSIYYFVFPALRV--VHSRHAYAAGAPV 442
            ::| .|..|.....|:      .|...|:.....:.|.:.:.:|.||:..  :||..    |:|.
  Rat   470 DVL-RETIKFMYTDWA------DRHNPETRRKTLLALFTDHQWVAPAVATADLHSNF----GSPT 523

  Fly   443 YFYRYDFDSEELIFPYRIMRLGRGVKGVSHADDLSYQF-------SSLLARRLPKESREYRNIER 500
            |||.:....:....|        .....:|.|::.|..       :.|......|.......:..
  Rat   524 YFYAFYHHCQTDQVP--------AWADAAHGDEVPYVLGIPMIGPTELFPCNFSKNDVMLSAVVM 580

  Fly   501 TVGIWTQFAATGNP 514
            |  .||.||.||:|
  Rat   581 T--YWTNFAKTGDP 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est7	NP_524261.1	COesterase	27..514	CDD:278561	160/590 (27%)
alpha-Est7	NP_524261.1	Aes	<116..>221	CDD:223730	48/154 (31%)
Nlgn1	XP_038957495.1	COesterase	52..646	CDD:395084	161/589 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336137
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840