DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est7 and Ces1d

DIOPT Version :9

Sequence 1:	NP_524261.1	Gene:	alpha-Est7 / 40901	FlyBaseID:	FBgn0015575	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_579829.3	Gene:	Ces1d / 113902	RGDID:	70896	Length:	565	Species:	Rattus norvegicus

Alignment Length:	601	Identity:	177/601 - (29%)
Similarity:	253/601 - (42%)	Gaps:	163/601 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 VADTEYGQVRGIKRLSL--YDVPYFSFEGIPYAQPPVGELRFKAPQRPIPWERVRD-------CS 89
            |.:|..|:|.| |.::|  :..|...|.|||:|:||:|.|||..||...||..|::       ||
  Rat    25 VVNTVKGKVLG-KYVNLEGFAQPVAVFLGIPFAKPPLGSLRFAPPQPAEPWNFVKNTTSYPPMCS 88

  Fly    90 QP-------------KDKAVQVQFVFDKVEGSEDCLYLNVYT-NNVKPDKARPVMVWIHGGGFII 140
            |.             :.:.:.:||       ||||||||||| .::..:...||||||||||.::
  Rat    89 QDAVGGQVLSELFTNRKENIPLQF-------SEDCLYLNVYTPADLTKNSRLPVMVWIHGGGLVV 146

  Fly   141 GEANREWYGPDYFMKEDVVLVTIQYRLGALGFMSLKSPELNVPGNAGLKDQVLALKWIKNNCASF 205
            |.|: .:.|......|:||:||||||||..||.|  :.:.:..||.|..|||.||.|:::|.|:|
  Rat   147 GGAS-TYDGQVLSAHENVVVVTIQYRLGIWGFFS--TGDEHSQGNWGHLDQVAALHWVQDNIANF 208

  Fly   206 GGDPNCITVFGESAGGASTHYMMLTDQTQGLFHRGILQSGSAICPWAYNGDITHNPYRIAKLVGY 270
            ||:|..:|:|||||||.|...::|:...:.||||.|.:||..:.......|.......||.|.|.
  Rat   209 GGNPGSVTIFGESAGGFSVSALVLSPLAKNLFHRAISESGVVLTSALITTDSKPIANLIATLSGC 273

  Fly   271 KGEDNDKDVLEFLQNVKAKDLI---RVEENVLTLEERMN-KIMFAFGPSLEPFSTPECVISKPPK 331
            |  .....|:......|.:|.:   .::.|:..|:...| |..:.|.|::    ....|:.|.|:
  Rat   274 K--TTTSAVMVHCLRQKTEDELLETSLKLNLFKLDLLGNPKESYPFLPTV----IDGVVLPKTPE 332

  Fly   332 EMMKTAWSNSIPMFIGNTSYE------------------------GLLW--VPEV----KLMPQV 366
            |::.....|::|..:|....|                        .|||  .|.:    |::|.|
  Rat   333 EILTEKSFNTVPYIVGINKQEFGWIIPTLMGYPLSEGKLDQKTAKSLLWKSYPTLKISEKMIPVV 397

  Fly   367 LQQLDAGTPFIPKELLATEPSKEKLDSWSAQIRDVHRTGSESTPDNYMDLCSIYYFVFPALRVVH 431
            .::...||         .:|:|.|                    |.:.||.:...|..|::.|
  Rat   398 AEKYFGGT---------DDPAKRK--------------------DLFQDLVADVMFGVPSVMV-- 431

  Fly   432 SRHAYAAGAPVYFYRYDFDSEELIFPYR-----IMRLGRGVKGVSHADDLSYQFSSLLARRLPKE 491
            ||....||||.:.|.         |.||     .|| .:.|.| .|.|:|...|.|...:  ...
  Rat   432 SRSHRDAGAPTFMYE---------FEYRPSFVSAMR-PKTVIG-DHGDELFSVFGSPFLK--DGA 483

  Fly   492 SREYRNIERTV-GIWTQFAATGNPYSEKINGMDTLTIDPVRKSDEVIKCLNISDDLKFIDLPEWP 555
            |.|..|:.:.| ..|..||..|:|     ||.                           .||.||
  Rat   484 SEEETNLSKMVMKYWANFARNGSP-----NGG---------------------------GLPHWP 516

  Fly   556 KLKVWESLYDDNKDLL 571
            :       ||..:..|
  Rat   517 E-------YDQKEGYL 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est7	NP_524261.1	COesterase	27..514	CDD:278561	167/542 (31%)
alpha-Est7	NP_524261.1	Aes	<116..>221	CDD:223730	51/105 (49%)
Ces1d	NP_579829.3	COesterase	24..545	CDD:278561	177/601 (29%)
		Aes	<121..>239	CDD:223730	55/120 (46%)
		Prevents secretion from ER. /evidence=ECO:0000255	562..565
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336159
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750