DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est7 and CEL

DIOPT Version :9

Sequence 1:	NP_524261.1	Gene:	alpha-Est7 / 40901	FlyBaseID:	FBgn0015575	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_001798.3	Gene:	CEL / 1056	HGNCID:	1848	Length:	753	Species:	Homo sapiens

Alignment Length:	530	Identity:	157/530 - (29%)
Similarity:	225/530 - (42%)	Gaps:	112/530 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 TEYGQVRGI-KRLSLYDVPYFSFEGIPYAQPPVGELRFKAPQRPIP---WERVRDCSQPKDKAVQ 97
            ||.|.|.|: |:|.|.......|:|||:|.|.      ||.:.|.|   |:........|.:.:|
Human    28 TEGGFVEGVNKKLGLLGDSVDIFKGIPFAAPT------KALENPQPHPGWQGTLKAKNFKKRCLQ 86

  Fly    98 VQFVFDKVEGSEDCLYLNVYTNNVKPDKAR--PVMVWIHGGGFIIGEA-------NREWYGPDYF 153
            .....|...|.|||||||::....:...:|  |||:||:||.|::|..       |..:.|.:..
Human    87 ATITQDSTYGDEDCLYLNIWVPQGRKQVSRDLPVMIWIYGGAFLMGSGHGANFLNNYLYDGEEIA 151

  Fly   154 MKEDVVLVTIQYRLGALGFMSLKSPELNVPGNAGLKDQVLALKWIKNNCASFGGDPNCITVFGES 218
            .:.:|::||..||:|.|||:|  :.:.|:|||.||:||.:|:.|:|.|.|:||||||.||:||||
Human   152 TRGNVIVVTFNYRVGPLGFLS--TGDANLPGNYGLRDQHMAIAWVKRNIAAFGGDPNNITLFGES 214

  Fly   219 AGGASTHYMMLTDQTQGLFHRGILQSGSAICPWAYNGDITHNPYRIAKLVGYKGEDNDKDVLEFL 283
            |||||.....|:...:||..|.|.|||.|:.||.    |..||...||.|..|......|.....
Human   215 AGGASVSLQTLSPYNKGLIRRAISQSGVALSPWV----IQKNPLFWAKKVAEKVGCPVGDAARMA 275

  Fly   284 QNVKAKDLIRVEENVLTLEERMNKIMFA-----------FGPSLEPFSTPECVISKPPKEMMKTA 337
            |.:|..|     ...|||   ..|:..|           |.|.::....|...|:         .
Human   276 QCLKVTD-----PRALTL---AYKVPLAGLEYPMLHYVGFVPVIDGDFIPADPIN---------L 323

  Fly   338 WSNS--IPMFIGNTSYEGLLW----VPEVKLMPQVLQQLD----------------AGTPF-IPK 379
            ::|:  |....|..:.:|.::    :|.:....:.:.:.|                |.|.| :..
Human   324 YANAADIDYIAGTNNMDGHIFASIDMPAINKGNKKVTEEDFYKLVSEFTITKGLRGAKTTFDVYT 388

  Fly   380 ELLATEPSKEKLDSWSAQIRDVHRTGSESTPDNYMDLCSIYYFVFPALRVVHSRHAYAAGAPVYF 444
            |..|.:||:                  |:.....:|..:...|:.|....:....|.|..|..|.
Human   389 ESWAQDPSQ------------------ENKKKTVVDFETDVLFLVPTEIALAQHRANAKSAKTYA 435

  Fly   445 YRYDFDSEELIFPYRIMRLGRGVKGVSHADDLSYQFSSLLARRLPKESREYRNIERTV-----GI 504
            |.:...|...::|..:        |..||||:.|.|....|     ....||..:|||     ..
Human   436 YLFSHPSRMPVYPKWV--------GADHADDIQYVFGKPFA-----TPTGYRPQDRTVSKAMIAY 487

  Fly   505 WTQFAATGNP 514
            ||.||.||:|
Human   488 WTNFAKTGDP 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est7	NP_524261.1	COesterase	27..514	CDD:278561	156/528 (30%)
alpha-Est7	NP_524261.1	Aes	<116..>221	CDD:223730	48/113 (42%)
CEL	NP_001798.3	Heparin-binding	21..121		32/98 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	555..753
		17 X 11 AA tandem repeats, glycodomain, O-linked (mucin type)	559..745
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142723
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.640