DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est7 and Ces2a

DIOPT Version :9

Sequence 1:	NP_524261.1	Gene:	alpha-Est7 / 40901	FlyBaseID:	FBgn0015575	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_598721.1	Gene:	Ces2a / 102022	MGIID:	2142491	Length:	558	Species:	Mus musculus

Alignment Length:	581	Identity:	174/581 - (29%)
Similarity:	252/581 - (43%)	Gaps:	136/581 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 VQQYRQSTNETVVADTEYGQVRGIKRLSLYDVP-----YFSFEGIPYAQPPVGELRFKAPQRPIP 81
            :|......:.:.:.:|..|||||    |...|.     ..:|.|||:|:||||.|||..|:.|.|
Mouse    21 LQHVHGQDSASPIRNTHRGQVRG----SFVHVKDTKSGVHAFLGIPFAKPPVGLLRFAPPEDPEP 81

  Fly    82 WERVRD-------CSQPK----DKAVQVQFVFDKVEGSEDCLYLNVYTNNVKPDKAR-----PVM 130
            |..|||       |.||.    :.|.::..:...:..||||||||:||    |..|:     |||
Mouse    82 WSGVRDGTSQPAMCLQPDIMNLEDAKEMNLILPPISMSEDCLYLNIYT----PTHAQEGSNLPVM 142

  Fly   131 VWIHGGGFIIGEANREWYGPDYFMKEDVVLVTIQYRLGALGFMSLKSPELNVPGNAGLKDQVLAL 195
            |||||||.::|.|:..... .....|::|:|.||||||.|||.|  :.:.:..||.|..|||.||
Mouse   143 VWIHGGGLVVGSASMNDVS-KLAATEEIVIVAIQYRLGVLGFFS--TGDQHARGNWGYLDQVAAL 204

  Fly   196 KWIKNNCASFGGDPNCITVFGESAGGASTHYMMLTDQTQGLFHRGILQSGSAICPWAYNGDITHN 260
            :|::.|.|.|||:.:.:|:||.||||.|....:|:..::||||..|:|||.|:.|...: |.:..
Mouse   205 RWVQKNIAYFGGNRDRVTIFGVSAGGTSVSSHILSPMSKGLFHGAIMQSGVALLPDLIS-DTSEV 268

  Fly   261 PYR-IAKLVGYKGEDNDKDVLEFLQNVKAKDLIRVEENVLTL--------------EERMNKIMF 310
            .|: :|.|.|.  |..|.:.|......|:|..|.....|..:              :|.:..:.|
Mouse   269 VYKTVANLSGC--EATDSEALIHCLRAKSKQEILAINQVFKMIPAVVDGEFLPKHPQELLTSMDF 331

  Fly   311 AFGPSLEPFSTPECVISKPPKEMMKTAWSNSIPMFIG------NTSYEGLLWVPEVKLMPQVLQQ 369
            ...||:...:|.||            .|  .:|||:|      |.:.|.|         |.||:.
Mouse   332 HPVPSIIGVNTDEC------------GW--GVPMFMGLDHIIKNITRETL---------PAVLKN 373

  Fly   370 LDAGTPFIPKELLATEPSKEKLDSWSAQIRDVHRTGSESTPDNYMDLCSIYYFVFPALRVVHSRH 434
            ..|      :.:|..|.|...::.:.....|     .|:....:.::...:.||.|||:|.|.:.
Mouse   374 TAA------RMMLPPECSHLLVEEYMGDTED-----PETLQAQFREMLGDFMFVIPALQVAHFQR 427

  Fly   435 AYAAGAPVYFYRYDFDSEEL--IFPYRIMRLGRGVKGVSHADDLSYQFSSLLARRLPKESREYRN 497
            :.   ||||||.:...|..:  :.|..:.        ..|.||:::.|.|.|.......:.|...
Mouse   428 SQ---APVYFYEFQHLSSFIKHVRPSHVK--------ADHGDDVAFVFGSYLWDMNLDLTEEEEL 481

  Fly   498 IER-TVGIWTQFAATGNPYSEKINGMDTLTIDPVRKSDEVIKCLNISDDLKFIDLPEWPKL 557
            ::| .:..|..||..|||.||                                .||.||.|
Mouse   482 LKRMMMKYWANFARNGNPNSE--------------------------------GLPSWPVL 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est7	NP_524261.1	COesterase	27..514	CDD:278561	164/531 (31%)
alpha-Est7	NP_524261.1	Aes	<116..>221	CDD:223730	48/109 (44%)
Ces2a	NP_598721.1	COesterase	30..537	CDD:278561	173/572 (30%)
Ces2a	NP_598721.1	Aes	<127..>230	CDD:223730	48/109 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832753
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.640