DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est7 and bche

DIOPT Version :9

Sequence 1:	NP_524261.1	Gene:	alpha-Est7 / 40901	FlyBaseID:	FBgn0015575	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	XP_002931610.1	Gene:	bche / 100495889	XenbaseID:	XB-GENE-980117	Length:	602	Species:	Xenopus tropicalis

Alignment Length:	591	Identity:	176/591 - (29%)
Similarity:	269/591 - (45%)	Gaps:	122/591 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 ETVVADTEYGQVRGIKRLSLYDVPYFSFEGIPYAQPPVGELRFKAPQRPIPWERVRDCSQPKDKA 95
            ||.:.||:||:|.|: ::|::.....:|.|||||:||:|:||||.|....||..:.:.||..:..
Frog    29 ETDIVDTKYGKVTGV-QISVFSGIITAFLGIPYAEPPIGDLRFKKPVPHKPWSEIWNASQYGNSC 92

  Fly    96 VQ-VQFVFDKVEG----------SEDCLYLNVYTNNVKPDKARPVMVWIHGGGFIIGEANREWYG 149
            .| |..:|....|          ||||||||::....||..| .|||||:||.|..|.::.:.|.
Frog    93 YQTVDQIFPGFSGAEMWNPNTQLSEDCLYLNIWIPTPKPRNA-SVMVWIYGGSFETGTSSLDLYD 156

  Fly   150 PDYFMK-EDVVLVTIQYRLGALGFMSLKSPELN-VPGNAGLKDQVLALKWIKNNCASFGGDPNCI 212
            ..:..: |.|::|::.||||||||::.  |..| .|||.||.||.|||:|:..|.|:|||:|..|
Frog   157 GKFLARTERVIVVSMNYRLGALGFLAF--PGNNEAPGNVGLFDQRLALQWVYENIAAFGGNPKSI 219

  Fly   213 TVFGESAGGASTHYMMLTDQTQGLFHRGILQSGSAICPWAY--NGDITHNPYRIAKLVG--YKGE 273
            |:|||||||||..|.||:.::.|.|.|.|:||.:|..|||.  ..:.::....:|.|:.  |:
Frog   220 TIFGESAGGASVSYHMLSPKSHGFFTRAIMQSATANAPWAVITKAEASNRALTLANLLNCFYR-- 282

  Fly   274 DNDKDVLEFLQNVKAKDLIRVEENVLTLEERMNKIMFAFGPSLEPFSTPECVISKPPKEMMKTAW 338
             |:.:::..|:|...:::.  |:.|..|..| :.|...|.|:::    .:.:|..|
Frog   283 -NETEIIACLRNKSPEEIF--EKAVSVLPHR-SVIEVNFPPTVD----GDFLIEMP--------- 330

  Fly   339 SNSIPMFIGNTSYEGLLWVPEVKLMPQVLQQL--DAGTPFI------------------------ 377
                         |.|:.:.::|...|:|..:  |.|:.|:
Frog   331 -------------EILMQLGQLKKKTQILTGVNKDEGSYFLVYGLPGFSKDHESFINRTQFHKSV 382

  Fly   378 ----PKELLATEPSKEKL----DSWSAQIRDVHRTGSESTPDNYMDLCSIYYFVFPALRVVHSRH 434
                ||   |||.:.:.:    .:|..:....|..      |...|:...|.|:.|.|.  .::.
Frog   383 KLAFPK---ATELAIDSVLFHYTNWEDEQNPSHNR------DAMDDIVGDYNFICPLLE--FTKW 436

  Fly   435 AYAAGAPVYFYRYDFDSEELIFPYRIMRLGRGVKGVSHADDLSYQFSSLLARRLPKESREYRNIE 499
            ....|...|.|.:...|.:|.:|        |..||.|..::.:.|...:.|||     .|...|
Frog   437 NSELGNNAYLYYFHHRSSKLTWP--------GWMGVMHGYEIEFVFGIPMYRRL-----NYTKAE 488

  Fly   500 RTVG-----IWTQFAATGNPYSEKINGMDTLTID-PVRKSDEVIKCLNISDDLKFIDLPEWPKLK 558
            .|:.     .|..||.||||     ||..:.... ||...||....:..::|.|........:.:
Frog   489 ETLSRTLMRYWANFAKTGNP-----NGAQSSENRWPVFTLDEQHYLMLGTEDSKTNRKMRAKQCR 548

  Fly   559 VWESLY 564
            .|.:.|
Frog   549 FWNNFY 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est7	NP_524261.1	COesterase	27..514	CDD:278561	164/538 (30%)
alpha-Est7	NP_524261.1	Aes	<116..>221	CDD:223730	50/106 (47%)
bche	XP_002931610.1	COesterase	32..550	CDD:365897	172/582 (30%)
bche	XP_002931610.1	AChE_tetra	565..599	CDD:370053
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910